Identification of Novel HSP90α/β Isoform Selective Inhibitors Using Structure-Based Drug Design. Demonstration of Potential Utility in Treating CNS Disorders such as Huntington’s Disease

Journal Article · Tue Apr 08 00:00:00 EDT 2014 · Journal of Medicinal Chemistry

DOI:https://doi.org/10.1021/jm500042s· OSTI ID:1497115

Ernst, Justin T. ^[1]; Neubert, Timothy ^[1]; Liu, Michael ^[1]; Sperry, Samuel ^[1]; Zuccola, Harmon ^[2]; Turnbull, Amy ^[1]; Fleck, Beth ^[1]; Kargo, William ^[1]; Woody, Lisa ^[1]; Chiang, Peggy ^[1]; Tran, Dao ^[1]; Chen, Weichao ^[1]; Snyder, Phillip ^[2]; Alcacio, Timothy ^[1]; Nezami, Azin ^[2]; Reynolds, James ^[1]; Alvi, Khisal ^[1]; Goulet, Lance ^[1]; Stamos, Dean ^[1]

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1. Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, California 92121, United States
2. Vertex Pharmaceuticals, 130 Waverly Street, Cambridge, Massachusetts 02139, United States

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
• Sponsoring Organization: NIHNIGMS
• OSTI ID: 1497115
• Journal Information: Journal of Medicinal Chemistry, Vol. 57, Issue 8; ISSN 0022-2623
• Publisher: American Chemical Society (ACS)
• Country of Publication: United States
• Language: ENGLISH