Workshop on Biological Science Opportunities Provided by the APS Upgrade
- Argonne National Lab. (ANL), Argonne, IL (United States)
Synchrotron-based macromolecular X-ray crystallography (MX) is the primary method for determining the structure of biological molecules including proteins, nucleic acids, complexes, and large assemblies at high resolution (e.g., 95% of all new Protein Data Bank [PDB] deposits in 2017). The Advanced Photon Source (APS), which is the largest and the most productive light source for MX, will be upgraded to a multi-bend achromat lattice (the Advanced Photon Source Upgrade — APS-U) that will deliver the ultimate diffraction-limited X-ray source with radically transformative MX capabilities. The specific advantages of the APS-U X-ray source include (1) increased brightness allowing delivery of intense beams with dimensions of 1-μm or less, resulting in a 100-fold improvement in signal-to-noise, (2) increased brightness at high energy (especially for energies of 12 keV-40 keV commonly used in MX) that can be exploited to reduce primary radiation damage, and (3) low-convergence X-ray beams that will be essential for the study of large macromolecular complexes at high resolution. A workshop on “Biological Science Opportunities Provided by the APS Upgrade” was organized at Argonne National Laboratory on August 18-20, 2018, to discuss the biological science opportunities offered by the unique new capabilities of the APS-U and how the broad structural biology community could best exploit them. The APS-U takes place in a context where advances in X-ray free-electron laser (XFEL) sources and cryo-electron microscopy (cryo-EM) have added to the constellation of techniques and propelled structural biology in new directions. Synergies exist between these different technologies and it is essential to develop enabling technologies that exploit the unique, world-leading, and synergistic characteristics of each light source to boost capabilities for producing leading-edge biological research for U.S. Department of Energy (DOE) missions in energy and environment, and National Institutes of Health (NIH) missions in human health.
- Research Organization:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-06CH11357
- OSTI ID:
- 1496875
- Report Number(s):
- ANL-19/04; 149564
- Country of Publication:
- United States
- Language:
- English
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