Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2

LaRochelle, Jonathan R.; Fodor, Michelle; Ellegast, Jana M.; Liu, Xiaoxi; Vemulapalli, Vidyasiri; Mohseni, Morvarid; Stams, Travis; Buhrlage, Sara J.; Stegmaier, Kimberly; LaMarche, Matthew J.; Acker, Michael G.; Blacklow, Stephen C.

doi:10.1016/j.bmc.2017.10.025

Title: Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2

Journal Article · Fri Dec 01 00:00:00 EST 2017 · Bioorganic and Medicinal Chemistry

DOI:https://doi.org/10.1016/j.bmc.2017.10.025· OSTI ID:1496372

LaRochelle, Jonathan R.; Fodor, Michelle; Ellegast, Jana M.; Liu, Xiaoxi; Vemulapalli, Vidyasiri; Mohseni, Morvarid; Stams, Travis; Buhrlage, Sara J.; Stegmaier, Kimberly; LaMarche, Matthew J.; Acker, Michael G.; Blacklow, Stephen C.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: DEAC02-06CH11357

OSTI ID:: 1496372

Journal Information:: Bioorganic and Medicinal Chemistry, Journal Name: Bioorganic and Medicinal Chemistry Vol. 25 Journal Issue: 24; ISSN 0968-0896

Publisher:: ElsevierCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Cited by: 36 works

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References (22)

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Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2 LaRochelle, Jonathan R.; Fodor, Michelle; Xu, Xiang Biochemistry, Vol. 55, Issue 15 https://doi.org/10.1021/acs.biochem.5b01287	journal	April 2016
PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs Prahallad, Anirudh; Heynen, Guus J. J. E.; Germano, Giovanni Cell Reports, Vol. 12, Issue 12 https://doi.org/10.1016/j.celrep.2015.08.037	journal	September 2015
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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases Chen, Ying-Nan P.; LaMarche, Matthew J.; Chan, Ho Man Nature, Vol. 535, Issue 7610 https://doi.org/10.1038/nature18621	journal	June 2016
Protein-tyrosine phosphatases and cancer Östman, Arne; Hellberg, Carina; Böhmer, Frank D. Nature Reviews Cancer, Vol. 6, Issue 4 https://doi.org/10.1038/nrc1837	journal	April 2006
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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome Tartaglia, Marco; Mehler, Ernest L.; Goldberg, Rosalie Nature Genetics, Vol. 29, Issue 4 https://doi.org/10.1038/ng772	journal	November 2001
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