Role of the highly conserved G68 residue in the yeast phosphorelay protein Ypd1: implications for interactions between histidine phosphotransfer (HPt) and response regulator proteins
Journal Article
·
· BMC Biochemistry (Online)
- Univ. of Oklahoma, Norman, OK (United States); Univ. of North Carolina, Chapel Hill, NC (United States)
- Univ. of Oklahoma, Norman, OK (United States)
- Univ. of Oklahoma, Norman, OK (United States); Pacira Pharmaceuticals, San Diego, CA (United States)
- Univ. of Oklahoma, Norman, OK (United States); Argonne National Lab. (ANL), Lemont, IL (United States)
Many bacteria and certain eukaryotes utilize multi-step His-to-Asp phosphorelays for adaptive responses to their extracellular environments. Histidine phosphotransfer (HPt) proteins function as key components of these pathways. HPt proteins are genetically diverse, but share a common tertiary fold with conserved residues near the active site. A surface-exposed glycine at the H + 4 position relative to the phosphorylatable histidine is found in a significant number of annotated HPt protein sequences. Furthermore previous reports demonstrated that substitutions at this position result in diminished phosphotransfer activity between HPt proteins and their cognate signaling partners.
- Research Organization:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- National Science Foundation (NSF); USDOE
- Grant/Contract Number:
- AC02-06CH11357
- OSTI ID:
- 1494700
- Journal Information:
- BMC Biochemistry (Online), Vol. 20, Issue 1; ISSN 1471-2091
- Publisher:
- BioMed CentralCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Cited by: 4 works
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Web of Science
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