Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

Kyle, J. E.; Burnum-Johnson, K. E.; Wendler, J. P.; Eisfeld, A. J.; Halfmann, Peter J.; Watanabe, Tokiko; Sahr, Foday; Smith, R. D.; Kawaoka, Y.; Waters, K. M.; Metz, T. O.

doi:10.1073/pnas.1815356116

Title: Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

Journal Article · Mon Feb 11 00:00:00 EST 2019 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.1815356116· OSTI ID:1494321

;

; Wendler, J. P.; Eisfeld, A. J.; Halfmann, Peter J.; Watanabe, Tokiko; Sahr, Foday; Smith, R. D.; Kawaoka, Y.; Waters, K. M.; Metz, T. O.

Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. In this work we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014–2016 Ebola virus outbreak, were profoundly altered. Focusing on how lipids are associated in human plasma, while factoring in the state of critical illness, we found that lipidome changes were related to EVD outcome and could identify states of disease and recovery. Specific changes in the lipidome suggested contributions from extracellular vesicles, viremia, liver dysfunction, apoptosis, autophagy, and general critical illness, and we identified possible targets for therapies enhancing EVD survival.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); Health and Labor Sciences Research; Ministry of Education, Culture, Sports, Science and Technology (MEXT); Emerging/Re-Emerging Infectious Diseases Project of Japan; National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH); National Institute of General Medical Sciences (NIGMS)

Grant/Contract Number:: AC05-76RL01830; 16H06429; 6K21723; 16H06434; U19AI106772; P41 GM103493

OSTI ID:: 1494321

Alternate ID(s):: OSTI ID: 1506690

Report Number(s):: PNNL-SA-136689

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Vol. 116 Journal Issue: 9; ISSN 0027-8424

Publisher:: National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 54 works

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