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Amplification of biological targets via on-chip culture for biosensing

Patent ·
OSTI ID:1493615
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The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

Research Organization:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
NA0003525
Assignee:
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
Patent Number(s):
10,126,299
Application Number:
15/820,836
OSTI ID:
1493615
Country of Publication:
United States
Language:
English

References (6)

Selective Immobilization of DNA and Antibody Probes on Electrode Arrays:  Simultaneous Electrochemical Detection of DNA and Protein on a Single Platform journal July 2007
Magnetic-adhesive based valves for microfluidic devices used in low-resource settings journal January 2016
Reagentless electrochemical immunoassay using electrocatalytic nanoparticle-modified antibodies journal January 2007
Laser Machined Plastic Laminates: Towards Portable Diagnostic Devices for Use in Low Resource Environments journal July 2015
Point-of-care nucleic acid testing for infectious diseases journal May 2011
Electrically addressable diazonium-functionalized antibodies for multianalyte electrochemical sensor applications journal January 2008

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