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Title: Neutron scattering in the biological sciences: progress and prospects

Journal Article · · Acta Crystallographica. Section D. Structural Biology
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  1. Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States). Dept. of Physics
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  3. Univ. of Copenhagen (Denmark). The Niels Bohr Inst.
  4. Univ. of Maryland, College Park, MD (United States). Materials Science and Engineeering
  5. City College of New York, NY (United States). Dept. of Chemistry and Biochemistry
  6. Ohio State Univ. College of Pharmacy, Columbus, OH (United States). Dept. of Medicinal Chemistry and Pharmacognosy
  7. Graduate School of China Academy of Engineering Physics, Beijing (China)
  8. National Inst. of Standards and Technology (NIST), Gaithersburg, MD (United States). Center for Neutron Research
  9. Univ. of Tennessee, Knoxville, TN (United States). Dept. of Chemistry
  10. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  11. Univ. of Maryland, College Park, MD (United States). Dept. of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization
  12. Inst. Laue-Langevin (ILL), Grenoble (France); Unive. Grenoble Alpes, Grenoble (France)
  13. Univ. of Pennsylvania, Philadelphia, PA (United States). Perelman School of Medicine, Dept. of Biochemistry and Biophysics
  14. National Inst. of Standards and Technology (NIST), Gaithersburg, MD (United States). Center for Neutron Research; Carnegie Mellon Univ., Pittsburgh, PA (United States). Dept. of Physics
  15. Shanghai Jiao Tong Univ. (China). Dept. of Physics and Astronomy, Inst. of Natural Sciences
  16. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Neutron Scattering Science Division; National Research Council, ON (Canada). Canadian Neutron Beam Centre
  17. Univ. of Maryland, Rockville, MD (United States); National Inst. of Standards and Technology (NIST), Gaithersburg, MD (United States). Inst. for Bioscience and Biotechnology Research
  18. Univ. of Alabama, Birmingham, AL (United States). Dept. of Chemistry
  19. Univ. d'Orleans, Orleans (France)
  20. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology and Soft Matter Division
  21. Georgia Inst. of Technology, Atlanta, GA (United States). School of Chemistry and Biochemistry
  22. Carnegie Mellon Univ., Pittsburgh, PA (United States). Dept. of Physics
  23. Univ. of Delaware, Newark, DE (United States). Dept. of Physics and Astrophysics
  24. Northeastern Univ., Boston, MA (United States). Dept. of Chemistry and Chemical Biology
  25. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); North Carolina State Univ., Raleigh, NC (United States). Dept. of Molecular and Structural Biochemistry
  26. Univ. of Leicester (United Kingdom). Leicester Inst. of Structural and Chemical Biology, Dept. of Molecular and Cell Biology
  27. Univ. of Cincinnati, OH (United States). Dept. of Chemical and Environmental Engineering
  28. Univ. of Illinois, Champaign, IL (United States)
  29. Inst. Laue-Langevin (ILL), Grenoble (France); Univ. Grenoble Alpes, Grenoble (France)
  30. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). UT/ORNL Center for Molecular Biophysics, Biosciences Division
  31. Univ. of Delaware, Newark, DE (United States). Center for Neutron Science, Dept. of Chemical and Biomolecular Engineering
  32. Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Chemistry
  33. Univ. of Illinois, Urbana-Champaign, IL (United States). Dept. of Nuclear, Plasma and Radiological Engineering, Dept. of Materials Science and Engineering, Dept. of Electrical and Computer Engineering, Beckman Inst. for Advanced Science and Technology
  34. Univ. of Tennessee, Knoxville, TN (United States). Dept. of of Biochemistry, Cellular and Molecular Biology

The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC05-00OR22725
OSTI ID:
1493122
Journal Information:
Acta Crystallographica. Section D. Structural Biology, Vol. 74, Issue 12; ISSN 2059-7983
Publisher:
IUCrCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 45 works
Citation information provided by
Web of Science

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