Evaluation of ⁷²Se/⁷²As generator and production of ⁷²Se for supplying ⁷²As as a potential PET imaging radionuclide

Journal Article · Tue Oct 30 00:00:00 EDT 2018 · Applied Radiation and Isotopes

DOI:https://doi.org/10.1016/j.apradiso.2018.10.026· OSTI ID:1489747

Feng, Yutian ^[1]; Phipps, Michael D. ^[1]; Phelps, Tim E. ^[1]; Okoye, Nkemakonam C. ^[1]; Baumeister, Jakob E. ^[1]; Wycoff, Donald E. ^[1]; Dorman, Eric F. ^[2]; Wooten, A. Lake ^[2]; Vlasenko, Vladislav ^[2]; Berendzen, Ashley F. ^[3]; Wilbur, D. Scott ^[2]; Hoffman, Timothy J. ^[3]; Cutler, Cathy S. ^[4]; Ketring, Alan R. ^[5]; Jurisson, Silvia S. ^[6]

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1. Univ. of Missouri, Columbia, MO (United States)
2. Univ. of Washington, Seattle, WA (United States)
3. Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO (United States)
4. Brookhaven National Lab. (BNL), Upton, NY (United States)
5. Univ. of Missouri Research Reactor Center, Columbia, MO (United States)
6. Univ. of Missouri, Columbia, MO (United States); Univ. of Missouri Research Reactor Center, Columbia, MO (United States)

Here, positron-emitting ⁷²As is the PET imaging counterpart for beta-emitting ⁷⁷As. Its parent, no carrier added (n.c.a.) ⁷²Se, was produced for a ⁷²Se/⁷²As generator by irradiating an enriched ^7°Ge metal-graphite target via the ⁷⁰Ge(α, 2 n)⁷²Se reaction. Target dissolution used a fast, environmentally friendly method with 93% radioactivity recovery. Chromatographic parameters of the ⁷²Se/⁷²As generator were evaluated, the eluted n.c.a. ⁷²As was characterized with a phantom imaging study, and the previously reported trithiol and aryl-dithiol ligand systems were radiolabeled with the separated n.c.a. ⁷²As in high yield.

• Research Organization: Brookhaven National Lab. (BNL), Upton, NY (United States)
• Sponsoring Organization: USDOE Office of Science (SC), Nuclear Physics (NP)
• Grant/Contract Number: SC0012704; SC0003851; SC0010283
• OSTI ID: 1489747
• Alternate ID(s): OSTI ID: 1636700
• Report Number(s): BNL-210844-2019-JAAM
• Journal Information: Applied Radiation and Isotopes, Vol. 143, Issue C; ISSN 0969-8043
• Publisher: Elsevier
• Country of Publication: United States
• Language: English

Related Subjects

43 PARTICLE ACCELERATORS
72Se
72As
72Se/72As generator
70Ge target
Alpha irradiation
Radiolabeling