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Title: Evaluation of 72Se/ 72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide

Abstract

Here, positron-emitting 72As is the PET imaging counterpart for beta-emitting 77As. Its parent, no carrier added (n.c.a.) 72Se, was produced for a 72Se/ 72As generator by irradiating an enriched Ge metal-graphite target via the 70Ge(α, 2 n) 72Se reaction. Target dissolution used a fast, environmentally friendly method with 93% radioactivity recovery. Chromatographic parameters of the 72Se/ 72As generator were evaluated, the eluted n.c.a. 72As was characterized with a phantom imaging study, and the previously reported trithiol and aryl-dithiol ligand systems were radiolabeled with the separated n.c.a. 72As in high yield.

Authors:
 [1];  [1];  [1];  [1];  [1];  [1];  [2];  [2];  [2];  [3];  [2];  [3];  [4];  [5];  [6]
  1. Univ. of Missouri, Columbia, MO (United States)
  2. Univ. of Washington, Seattle, WA (United States)
  3. Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO (United States)
  4. Brookhaven National Lab. (BNL), Upton, NY (United States)
  5. Univ. of Missouri Research Reactor Center, Columbia, MO (United States)
  6. Univ. of Missouri, Columbia, MO (United States); Univ. of Missouri Research Reactor Center, Columbia, MO (United States)
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
OSTI Identifier:
1489747
Report Number(s):
BNL-210844-2019-JAAM
Journal ID: ISSN 0969-8043
Grant/Contract Number:  
SC0012704
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Applied Radiation and Isotopes
Additional Journal Information:
Journal Volume: 143; Journal Issue: C; Journal ID: ISSN 0969-8043
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS; 72Se; 72As; 72Se/72As generator; 70Ge target; Alpha irradiation; Radiolabeling

Citation Formats

Feng, Yutian, Phipps, Michael D., Phelps, Tim E., Okoye, Nkemakonam C., Baumeister, Jakob E., Wycoff, Donald E., Dorman, Eric F., Wooten, A. Lake, Vlasenko, Vladislav, Berendzen, Ashley F., Wilbur, D. Scott, Hoffman, Timothy J., Cutler, Cathy S., Ketring, Alan R., and Jurisson, Silvia S. Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide. United States: N. p., 2018. Web. doi:10.1016/j.apradiso.2018.10.026.
Feng, Yutian, Phipps, Michael D., Phelps, Tim E., Okoye, Nkemakonam C., Baumeister, Jakob E., Wycoff, Donald E., Dorman, Eric F., Wooten, A. Lake, Vlasenko, Vladislav, Berendzen, Ashley F., Wilbur, D. Scott, Hoffman, Timothy J., Cutler, Cathy S., Ketring, Alan R., & Jurisson, Silvia S. Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide. United States. doi:10.1016/j.apradiso.2018.10.026.
Feng, Yutian, Phipps, Michael D., Phelps, Tim E., Okoye, Nkemakonam C., Baumeister, Jakob E., Wycoff, Donald E., Dorman, Eric F., Wooten, A. Lake, Vlasenko, Vladislav, Berendzen, Ashley F., Wilbur, D. Scott, Hoffman, Timothy J., Cutler, Cathy S., Ketring, Alan R., and Jurisson, Silvia S. Tue . "Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide". United States. doi:10.1016/j.apradiso.2018.10.026.
@article{osti_1489747,
title = {Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide},
author = {Feng, Yutian and Phipps, Michael D. and Phelps, Tim E. and Okoye, Nkemakonam C. and Baumeister, Jakob E. and Wycoff, Donald E. and Dorman, Eric F. and Wooten, A. Lake and Vlasenko, Vladislav and Berendzen, Ashley F. and Wilbur, D. Scott and Hoffman, Timothy J. and Cutler, Cathy S. and Ketring, Alan R. and Jurisson, Silvia S.},
abstractNote = {Here, positron-emitting 72As is the PET imaging counterpart for beta-emitting 77As. Its parent, no carrier added (n.c.a.) 72Se, was produced for a 72Se/72As generator by irradiating an enriched 7°Ge metal-graphite target via the 70Ge(α, 2 n)72Se reaction. Target dissolution used a fast, environmentally friendly method with 93% radioactivity recovery. Chromatographic parameters of the 72Se/72As generator were evaluated, the eluted n.c.a. 72As was characterized with a phantom imaging study, and the previously reported trithiol and aryl-dithiol ligand systems were radiolabeled with the separated n.c.a. 72As in high yield.},
doi = {10.1016/j.apradiso.2018.10.026},
journal = {Applied Radiation and Isotopes},
issn = {0969-8043},
number = C,
volume = 143,
place = {United States},
year = {2018},
month = {10}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on October 30, 2019
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