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Title: Self-assembly of nanoparticles into biomimetic capsid-like nanoshells

Abstract

Nanoscale compartments are one of the foundational elements of living systems. Capsids, carboxysomes, exosomes, vacuoles and other nanoshells easily self-assemble from biomolecules such as lipids or proteins, but not from inorganic nanomaterials because of difficulties with the replication of spherical tiling. Here we show that stabilizer-free polydispersed inorganic nanoparticles (NPs) can spontaneously organize into porous nanoshells. The association of water-soluble CdS NPs into self-limited spherical capsules is the result of scale-modified electrostatic, dispersion and other colloidal forces. They cannot be accurately described by the Derjaguin–Landau–Vervey–Overbeek theory, whereas molecular-dynamics simulations with combined atomistic and coarse-grained description of NPs reveal the emergence of nanoshells and some of their stabilization mechanisms. Morphology of the simulated assemblies formed under different conditions matched nearly perfectly the transmission electron microscopy tomography data. This study bridges the gap between biological and inorganic self-assembling nanosystems and conceptualizes a new pathway to spontaneous compartmentalization for a wide range of inorganic NPs including those existing on prebiotic Earth.

Authors:
ORCiD logo [1];  [2];  [3];  [4];  [5];  [6]; ORCiD logo [7]
  1. Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Chemical Engineering and Biointerfaces Inst.; Harbin Inst. of Technology (China). Key Lab. of Microsystems and Micronanostructures Manufacturing
  2. Univ. of Illinois, Chicago, IL (United States). Dept. of Chemistry
  3. Univ. of Pittsburgh, PA (United States). Dept. of Structural Biology
  4. Univ. of Michigan, Ann Arbor, MI (United States). Biointerfaces Inst.; Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Biomedical Engineering
  5. Univ. of Pittsburgh, PA (United States). Dept. of Structural Biology and Dept. of Mechanical Engineering and Materials Science
  6. Univ. of Illinois, Chicago, IL (United States). Dept. of Chemistry and Dept. of Biopharmaceutical Sciences
  7. Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Chemical Engineering and Biointerfaces Inst.; Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Biomedical Engineering; Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Materials Science and Engineering; Michigan Center for Integrative Research in Critical Care, Ann Arbor, MI (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Laboratory-National Energy Research Scientific Computing Center
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1489148
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Journal Article
Journal Name:
Nature Chemistry
Additional Journal Information:
Journal Volume: 9; Journal Issue: 3; Journal ID: ISSN 1755-4330
Country of Publication:
United States
Language:
English

Citation Formats

Yang, Ming, Chan, Henry, Zhao, Gongpu, Bahng, Joong Hwan, Zhang, Peijun, Král, Petr, and Kotov, Nicholas A. Self-assembly of nanoparticles into biomimetic capsid-like nanoshells. United States: N. p., 2016. Web. doi:10.1038/NCHEM.2641.
Yang, Ming, Chan, Henry, Zhao, Gongpu, Bahng, Joong Hwan, Zhang, Peijun, Král, Petr, & Kotov, Nicholas A. Self-assembly of nanoparticles into biomimetic capsid-like nanoshells. United States. doi:10.1038/NCHEM.2641.
Yang, Ming, Chan, Henry, Zhao, Gongpu, Bahng, Joong Hwan, Zhang, Peijun, Král, Petr, and Kotov, Nicholas A. Mon . "Self-assembly of nanoparticles into biomimetic capsid-like nanoshells". United States. doi:10.1038/NCHEM.2641.
@article{osti_1489148,
title = {Self-assembly of nanoparticles into biomimetic capsid-like nanoshells},
author = {Yang, Ming and Chan, Henry and Zhao, Gongpu and Bahng, Joong Hwan and Zhang, Peijun and Král, Petr and Kotov, Nicholas A.},
abstractNote = {Nanoscale compartments are one of the foundational elements of living systems. Capsids, carboxysomes, exosomes, vacuoles and other nanoshells easily self-assemble from biomolecules such as lipids or proteins, but not from inorganic nanomaterials because of difficulties with the replication of spherical tiling. Here we show that stabilizer-free polydispersed inorganic nanoparticles (NPs) can spontaneously organize into porous nanoshells. The association of water-soluble CdS NPs into self-limited spherical capsules is the result of scale-modified electrostatic, dispersion and other colloidal forces. They cannot be accurately described by the Derjaguin–Landau–Vervey–Overbeek theory, whereas molecular-dynamics simulations with combined atomistic and coarse-grained description of NPs reveal the emergence of nanoshells and some of their stabilization mechanisms. Morphology of the simulated assemblies formed under different conditions matched nearly perfectly the transmission electron microscopy tomography data. This study bridges the gap between biological and inorganic self-assembling nanosystems and conceptualizes a new pathway to spontaneous compartmentalization for a wide range of inorganic NPs including those existing on prebiotic Earth.},
doi = {10.1038/NCHEM.2641},
journal = {Nature Chemistry},
issn = {1755-4330},
number = 3,
volume = 9,
place = {United States},
year = {2016},
month = {11}
}

Works referenced in this record:

Higher-Order Organization by Mesoscale Self-Assembly and Transformation of Hybrid Nanostructures
journal, May 2003

  • Cölfen, Helmut; Mann, Stephen
  • Angewandte Chemie International Edition, Vol. 42, Issue 21
  • DOI: 10.1002/anie.200200562

Advanced drug delivery devices via self-assembly of amphiphilic block copolymers
journal, December 2001

  • Rösler, Annette; Vandermeulen, Guido W. M.; Klok, Harm-Anton
  • Advanced Drug Delivery Reviews, Vol. 53, Issue 1
  • DOI: 10.1016/S0169-409X(01)00222-8

Fast tomographic reconstruction on multicore computers
journal, December 2010


Unknown Aspects of Self-Assembly of PbS Microscale Superstructures
journal, April 2012

  • Querejeta-Fernández, Ana; Hernández-Garrido, Juan C.; Yang, Hengxi
  • ACS Nano, Vol. 6, Issue 5
  • DOI: 10.1021/nn300890s

Self-Assembled Nanoreactors as Highly Active Catalysts in the Hydrolytic Kinetic Resolution (HKR) of Epoxides in Water
journal, February 2006

  • Rossbach, Benjamin M.; Leopold, Kerstin; Weberskirch, Ralf
  • Angewandte Chemie International Edition, Vol. 45, Issue 8
  • DOI: 10.1002/anie.200503291

Self-assembly of self-limiting monodisperse supraparticles from polydisperse nanoparticles
journal, August 2011

  • Xia, Yunsheng; Nguyen, Trung Dac; Yang, Ming
  • Nature Nanotechnology, Vol. 6, Issue 9
  • DOI: 10.1038/nnano.2011.121

Cascade Reactions in Multicompartmentalized Polymersomes
journal, November 2013

  • Peters, Ruud J. R. W.; Marguet, Maïté; Marais, Sébastien
  • Angewandte Chemie International Edition, Vol. 53, Issue 1
  • DOI: 10.1002/anie.201308141

Synthesis of cadmium sulphide superlattices using self-assembled bacterial S-layers
journal, October 1997

  • Shenton, Wayne; Pum, Dietmar; Sleytr, Uwe B.
  • Nature, Vol. 389, Issue 6651
  • DOI: 10.1038/39287

Light-Controlled Self-Assembly of Semiconductor Nanoparticles into Twisted Ribbons
journal, February 2010


Formation of Colloidal CuO Nanocrystallites and Their Spherical Aggregation and Reductive Transformation to Hollow Cu 2 O Nanospheres
journal, February 2005

  • Chang, Yu; Teo, Joong Jiat; Zeng, Hua Chun
  • Langmuir, Vol. 21, Issue 3
  • DOI: 10.1021/la047671l

Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics
journal, May 2013

  • Zhao, Gongpu; Perilla, Juan R.; Yufenyuy, Ernest L.
  • Nature, Vol. 497, Issue 7451
  • DOI: 10.1038/nature12162

Architecture and material properties of diatom shells provide effective mechanical protection
journal, February 2003

  • Hamm, Christian E.; Merkel, Rudolf; Springer, Olaf
  • Nature, Vol. 421, Issue 6925
  • DOI: 10.1038/nature01416

Formation of Hollow Nanocrystals Through the Nanoscale Kirkendall Effect
journal, April 2004


Ultrahigh stress and strain in hierarchically structured hollow nanoparticles
journal, October 2008

  • Shan, Z. W.; Adesso, G.; Cabot, A.
  • Nature Materials, Vol. 7, Issue 12
  • DOI: 10.1038/nmat2295

Metal Nanostructures with Hollow Interiors
journal, April 2003


Nonadditivity of nanoparticle interactions
journal, October 2015


Signals from the lysosome: a control centre for cellular clearance and energy metabolism
journal, April 2013

  • Settembre, Carmine; Fraldi, Alessandro; Medina, Diego L.
  • Nature Reviews Molecular Cell Biology, Vol. 14, Issue 5
  • DOI: 10.1038/nrm3565

Hydrothermal Synthesis and Photocatalytic Activity of Zinc Oxide Hollow Spheres
journal, July 2008

  • Yu, Jiaguo; Yu, Xiaoxiao
  • Environmental Science & Technology, Vol. 42, Issue 13
  • DOI: 10.1021/es800036n

A "Double-Diamond Superlattice" Built Up of Cd17S4(SCH2CH2OH)26 Clusters
journal, March 1995


Cryo-electron tomography: 3-dimensional imaging of soft matter
journal, January 2011

  • Nudelman, Fabio; de With, Gijsbertus; Sommerdijk, Nico A. J. M.
  • Soft Matter, Vol. 7, Issue 1
  • DOI: 10.1039/C0SM00441C

Vesicles and Liposomes: A Self-Assembly Principle Beyond Lipids
journal, August 2003


Self-limited self-assembly of nanoparticles into supraparticles: towards supramolecular colloidal materials by design
journal, January 2016

  • Piccinini, Esteban; Pallarola, Diego; Battaglini, Fernando
  • Molecular Systems Design & Engineering, Vol. 1, Issue 2
  • DOI: 10.1039/C6ME00016A

Prokaryotic photosynthesis and phototrophy illuminated
journal, November 2006


Self-Assembly of CdTe Nanocrystals into Free-Floating Sheets
journal, October 2006


Virus shapes and buckling transitions in spherical shells
journal, November 2003


Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
journal, November 2003

  • Hirsch, L. R.; Stafford, R. J.; Bankson, J. A.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 23, p. 13549-13554
  • DOI: 10.1073/pnas.2232479100

Noise Reduction in Electron Tomographic Reconstructions Using Nonlinear Anisotropic Diffusion
journal, September 2001

  • Frangakis, Achilleas S.; Hegerl, Reiner
  • Journal of Structural Biology, Vol. 135, Issue 3
  • DOI: 10.1006/jsbi.2001.4406

Atomic-Level Models of the Bacterial Carboxysome Shell
journal, February 2008


What Is the Effective Charge of TGA-Stabilized CdTe Nanocolloids?
journal, May 2005

  • Yaroslavov, Alexander A.; Sinani, Vladimir A.; Efimova, Anna A.
  • Journal of the American Chemical Society, Vol. 127, Issue 20
  • DOI: 10.1021/ja051095d

Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic.
journal, December 1992

  • Kirnbauer, R.; Booy, F.; Cheng, N.
  • Proceedings of the National Academy of Sciences, Vol. 89, Issue 24
  • DOI: 10.1073/pnas.89.24.12180

UCSF Chimera?A visualization system for exploratory research and analysis
journal, January 2004

  • Pettersen, Eric F.; Goddard, Thomas D.; Huang, Conrad C.
  • Journal of Computational Chemistry, Vol. 25, Issue 13
  • DOI: 10.1002/jcc.20084

Computer Visualization of Three-Dimensional Image Data Using IMOD
journal, January 1996

  • Kremer, James R.; Mastronarde, David N.; McIntosh, J. Richard
  • Journal of Structural Biology, Vol. 116, Issue 1
  • DOI: 10.1006/jsbi.1996.0013

The origin of life—a review of facts and speculations
journal, December 1998


Monte Carlo Computer Simulation of Chain Formation from Nanoparticles
journal, April 2006

  • Sinyagin, Alex Y.; Belov, Artem; Tang, Zhioyng
  • The Journal of Physical Chemistry B, Vol. 110, Issue 14
  • DOI: 10.1021/jp057105e

Nanoengineering of Inorganic and Hybrid Hollow Spheres by Colloidal Templating
journal, November 1998