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Title: Multifunctional GdVO 4: Eu core–shell nanoparticles containing 225Ac for targeted alpha therapy and molecular imaging

Abstract

Gadolinium vanadate nanoparticles (NPs) doped with europium, in concentrations between 5–40%, were synthesized via an aqueous route to prove their multimodal imaging functionalities and their performance as radionuclide carriers for targeted alpha therapy. Core–shell Gd 0.8Eu 0.2VO 4 NPs were doped with the α-emitting actinium-225 to assess the in vitro retention of 225Ac and its decay daughters; francium-221 and bismuth-213. Gd 0.8Eu 0.2VO 4 core–shell NPs were obtained using a precipitation synthesis route having a tetragonal system, a spherical morphology, and a uniform particle size distribution. Gd 0.8Eu 0.2VO 4 core–shell NPs displayed the characteristic intense emission at 618 nm (red) and paramagnetic behavior of Eu and Gd cations, respectively. Partial retention of radionuclides was obtained with Gd 0.8Eu 0.2VO 4 core NPs, while deposition of two nonradioactive Gd 0.8Eu 0.2VO 4 shells significantly decreased the leakage of both 225Ac and 221Fr. As a result, the luminescence and magnetic functionalities as well as radionuclide retention capabilities of Gd 0.8Eu 0.2VO 4 core–shell NPs demonstrate their potential for biomedical applications.

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [2]; ORCiD logo [1]
  1. Virginia Commonwealth Univ., Richmond, VA (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1486950
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Journal of Materials Chemistry. B
Additional Journal Information:
Journal Volume: 6; Journal Issue: 47; Journal ID: ISSN 2050-750X
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Actinium-225; francium-221; bismuth-213; multifunctional nanoparticles; targeted alpha therapy; gadolinium and europium vanadate

Citation Formats

Toro-González, Miguel T., Copping, Roy, Mirzadeh, Saed, and Rojas, Jessika V. Multifunctional GdVO4: Eu core–shell nanoparticles containing 225Ac for targeted alpha therapy and molecular imaging. United States: N. p., 2018. Web. doi:10.1039/C8TB02173B.
Toro-González, Miguel T., Copping, Roy, Mirzadeh, Saed, & Rojas, Jessika V. Multifunctional GdVO4: Eu core–shell nanoparticles containing 225Ac for targeted alpha therapy and molecular imaging. United States. doi:10.1039/C8TB02173B.
Toro-González, Miguel T., Copping, Roy, Mirzadeh, Saed, and Rojas, Jessika V. Tue . "Multifunctional GdVO4: Eu core–shell nanoparticles containing 225Ac for targeted alpha therapy and molecular imaging". United States. doi:10.1039/C8TB02173B.
@article{osti_1486950,
title = {Multifunctional GdVO4: Eu core–shell nanoparticles containing 225Ac for targeted alpha therapy and molecular imaging},
author = {Toro-González, Miguel T. and Copping, Roy and Mirzadeh, Saed and Rojas, Jessika V.},
abstractNote = {Gadolinium vanadate nanoparticles (NPs) doped with europium, in concentrations between 5–40%, were synthesized via an aqueous route to prove their multimodal imaging functionalities and their performance as radionuclide carriers for targeted alpha therapy. Core–shell Gd0.8Eu0.2VO4 NPs were doped with the α-emitting actinium-225 to assess the in vitro retention of 225Ac and its decay daughters; francium-221 and bismuth-213. Gd0.8Eu0.2VO4 core–shell NPs were obtained using a precipitation synthesis route having a tetragonal system, a spherical morphology, and a uniform particle size distribution. Gd0.8Eu0.2VO4 core–shell NPs displayed the characteristic intense emission at 618 nm (red) and paramagnetic behavior of Eu and Gd cations, respectively. Partial retention of radionuclides was obtained with Gd0.8Eu0.2VO4 core NPs, while deposition of two nonradioactive Gd0.8Eu0.2VO4 shells significantly decreased the leakage of both 225Ac and 221Fr. As a result, the luminescence and magnetic functionalities as well as radionuclide retention capabilities of Gd0.8Eu0.2VO4 core–shell NPs demonstrate their potential for biomedical applications.},
doi = {10.1039/C8TB02173B},
journal = {Journal of Materials Chemistry. B},
issn = {2050-750X},
number = 47,
volume = 6,
place = {United States},
year = {2018},
month = {11}
}

Journal Article:
Free Publicly Available Full Text
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