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Title: Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-infrared Sub-window

Abstract

Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has gained increasing interest in clinical application. Till now, very few studies have been exploited in the small-molecule fluorophores with both excitation and emission in the NIR-II window. Inspired by indocyanine green structure, a series of polymethine dyes with both absorption and emission in NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in NIR-IIa (1300-1400 nm) sub-window under 1064 nm excitation with that in NIR-II window under 808 nm excitation. The signal-background ratio (SBR) and tumor to normal tissue ratio (T/NT) achieved great improvement under 1064 nm excitation in the imaging of mouse blood pool and U87 glioma tumors. Furthermore, our study not only introduces a broadband emission fluorophore for both NIR-II and NIR-IIa imaging, but also reveals the advantages of NIR-II excitation over NIR-I in in vivo imaging.

Authors:
 [1];  [2];  [2];  [3];  [3];  [4];  [2];  [3];  [5]
  1. Wuhan Univ. School of Pharmaceutical Sciences, Wuhan (China); Stanford Univ., Stanford, CA (United States)
  2. Wuhan Univ. School of Pharmaceutical Sciences, Wuhan (China)
  3. Stanford Univ., Stanford, CA (United States)
  4. Tibet Univ., Lasa (China)
  5. Wuhan Univ. School of Pharmaceutical Sciences, Wuhan (China); Tibet Univ., Lasa (China); Shenzhen Institute of Wuhan Univ., Shenzhen (China)
Publication Date:
Research Org.:
The Leland Stanford Junior Univ., Palo Alto, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1485259
Grant/Contract Number:  
SC0008397
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Journal of Medicinal Chemistry
Additional Journal Information:
Journal Volume: 62; Journal Issue: 4; Journal ID: ISSN 0022-2623
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 59 BASIC BIOLOGICAL SCIENCES; Polymethine thiopyrylium salts; Second near-infrared window; U87MG glioma tumor; Molecular imaging

Citation Formats

Ding, Bingbing, Xiao, Yuling, Zhou, Hui, Zhang, Xiao, Qu, Chunrong, Xu, Fuchun, Deng, Zixin, Cheng, Zhen, and Hong, Xuechuan. Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-infrared Sub-window. United States: N. p., 2018. Web. doi:10.1021/acs.jmedchem.8b01682.
Ding, Bingbing, Xiao, Yuling, Zhou, Hui, Zhang, Xiao, Qu, Chunrong, Xu, Fuchun, Deng, Zixin, Cheng, Zhen, & Hong, Xuechuan. Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-infrared Sub-window. United States. doi:10.1021/acs.jmedchem.8b01682.
Ding, Bingbing, Xiao, Yuling, Zhou, Hui, Zhang, Xiao, Qu, Chunrong, Xu, Fuchun, Deng, Zixin, Cheng, Zhen, and Hong, Xuechuan. Sun . "Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-infrared Sub-window". United States. doi:10.1021/acs.jmedchem.8b01682. https://www.osti.gov/servlets/purl/1485259.
@article{osti_1485259,
title = {Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-infrared Sub-window},
author = {Ding, Bingbing and Xiao, Yuling and Zhou, Hui and Zhang, Xiao and Qu, Chunrong and Xu, Fuchun and Deng, Zixin and Cheng, Zhen and Hong, Xuechuan},
abstractNote = {Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has gained increasing interest in clinical application. Till now, very few studies have been exploited in the small-molecule fluorophores with both excitation and emission in the NIR-II window. Inspired by indocyanine green structure, a series of polymethine dyes with both absorption and emission in NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in NIR-IIa (1300-1400 nm) sub-window under 1064 nm excitation with that in NIR-II window under 808 nm excitation. The signal-background ratio (SBR) and tumor to normal tissue ratio (T/NT) achieved great improvement under 1064 nm excitation in the imaging of mouse blood pool and U87 glioma tumors. Furthermore, our study not only introduces a broadband emission fluorophore for both NIR-II and NIR-IIa imaging, but also reveals the advantages of NIR-II excitation over NIR-I in in vivo imaging.},
doi = {10.1021/acs.jmedchem.8b01682},
journal = {Journal of Medicinal Chemistry},
issn = {0022-2623},
number = 4,
volume = 62,
place = {United States},
year = {2018},
month = {12}
}

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Cited by: 17 works
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