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Title: Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X-ray Structural Studies

Authors:
ORCiD logo [1];  [1];  [1];  [1];  [2];  [2];  [3];  [3]; ORCiD logo [3];  [4]
  1. Department of Chemistry and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States
  2. Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo 162-8655, Japan
  3. Department of Biology, Molecular Basis of Disease, Georgia State University, Atlanta, Georgia 30303, United States
  4. Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo 162-8655, Japan; Departments of Infectious Diseases and Hematology, Kumamoto University Graduate School of Biomedical Sciences, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1484805
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Medicinal Chemistry; Journal Volume: 61; Journal Issue: 21
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Ghosh, Arun K., Williams, Jacqueline N., Ho, Rachel Y., Simpson, Hannah M., Hattori, Shin-ichiro, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T., and Mitsuya, Hiroaki. Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X-ray Structural Studies. United States: N. p., 2018. Web. doi:10.1021/acs.jmedchem.8b01227.
Ghosh, Arun K., Williams, Jacqueline N., Ho, Rachel Y., Simpson, Hannah M., Hattori, Shin-ichiro, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T., & Mitsuya, Hiroaki. Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X-ray Structural Studies. United States. doi:10.1021/acs.jmedchem.8b01227.
Ghosh, Arun K., Williams, Jacqueline N., Ho, Rachel Y., Simpson, Hannah M., Hattori, Shin-ichiro, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T., and Mitsuya, Hiroaki. Mon . "Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X-ray Structural Studies". United States. doi:10.1021/acs.jmedchem.8b01227.
@article{osti_1484805,
title = {Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X-ray Structural Studies},
author = {Ghosh, Arun K. and Williams, Jacqueline N. and Ho, Rachel Y. and Simpson, Hannah M. and Hattori, Shin-ichiro and Hayashi, Hironori and Agniswamy, Johnson and Wang, Yuan-Fang and Weber, Irene T. and Mitsuya, Hiroaki},
abstractNote = {},
doi = {10.1021/acs.jmedchem.8b01227},
journal = {Journal of Medicinal Chemistry},
number = 21,
volume = 61,
place = {United States},
year = {Mon Oct 22 00:00:00 EDT 2018},
month = {Mon Oct 22 00:00:00 EDT 2018}
}