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Title: Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers

Abstract

An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.

Inventors:
; ; ; ; ;
Publication Date:
Research Org.:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1484243
Patent Number(s):
10,081,005
Application Number:
14/777,973
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, CA) CHO
DOE Contract Number:  
FG02-06ER64249; SC0001249
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Mar 26
Country of Publication:
United States
Language:
English

Citation Formats

Moore, Melissa, Van Dam, R. Michael, Quinn, Kevin, Claggett, Shane, Herman, Henry, and Lazari, Mark. Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers. United States: N. p., 2018. Web.
Moore, Melissa, Van Dam, R. Michael, Quinn, Kevin, Claggett, Shane, Herman, Henry, & Lazari, Mark. Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers. United States.
Moore, Melissa, Van Dam, R. Michael, Quinn, Kevin, Claggett, Shane, Herman, Henry, and Lazari, Mark. Tue . "Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers". United States. doi:. https://www.osti.gov/servlets/purl/1484243.
@article{osti_1484243,
title = {Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers},
author = {Moore, Melissa and Van Dam, R. Michael and Quinn, Kevin and Claggett, Shane and Herman, Henry and Lazari, Mark},
abstractNote = {An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 25 00:00:00 EDT 2018},
month = {Tue Sep 25 00:00:00 EDT 2018}
}

Patent:

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Works referenced in this record:

Improved synthesis of 2?-deoxy-2?-[18F]-fluoro-1-?-d-arabinofuranosyl-5-iodouracil ([18F]-FIAU)
journal, May 2010

  • Anderson, Harry; Pillarsetty, NagaVaraKishore; Cantorias, Melchor
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Automated synthesis of 2?-deoxy-2?-[18F]fluoro-5-methyl-1-?-d-arabinofuranosyluracil ([18F]-FMAU) using a one reactor radiosynthesis module
journal, February 2011