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Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers

Patent ·
OSTI ID:1484243
; ; ; ; ;

An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.

Research Organization:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-06ER64249; SC0001249
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, CA)
Patent Number(s):
10,081,005
Application Number:
14/777,973
OSTI ID:
1484243
Country of Publication:
United States
Language:
English

References (11)

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journal January 2002
A fully automated synthesis of [ 18 F]-FEAU and [ 18 F]-FMAU using a novel dual reactor radiosynthesis module journal November 2009
Automation for Optimised Production of Fluorine-18-Labelled Radiopharmaceuticals journal July 2010
Fluorine-18 radiopharmaceuticals beyond [18F]FDG for use in oncology and neurosciences journal October 2010
Synthesis of [18F]-labeled adenosine analogues as potential PET imaging agents
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journal January 2003
Abstract 5746: ARC-P HS+: A versatile radiosynthesizer for the production of PET tracers conference November 2014
The improved syntheses of 5-substituted 2′-[18F]fluoro-2′-deoxy-arabinofuranosyluracil derivatives ([18F]FAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU and [18F]FIAU) using a multistep one-pot strategy journal July 2011
Improved synthesis of 2′-deoxy-2′-[18F]-fluoro-1-β-d-arabinofuranosyl-5-iodouracil ([18F]-FIAU) journal May 2010
Emerging Technologies for Decentralized Production of PET Tracers
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book February 2012
Automated synthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]-FMAU) using a one reactor radiosynthesis module journal February 2011

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