The N-terminal 14-mer model peptide of human Ctr1 can collect Cu( ii ) from albumin. Implications for copper uptake by Ctr1

Stefaniak, Ewelina; Płonka, Dawid; Drew, Simon C.; Bossak-Ahmad, Karolina; Haas, Kathryn L.; Pushie, M. Jake; Faller, Peter; Wezynfeld, Nina E.; Bal, Wojciech

doi:10.1039/C8MT00274F

Title: The N-terminal 14-mer model peptide of human Ctr1 can collect Cu( ii ) from albumin. Implications for copper uptake by Ctr1

Journal Article · Wed Dec 12 00:00:00 EST 2018 · Metallomics

DOI:https://doi.org/10.1039/C8MT00274F· OSTI ID:1483907

Stefaniak, Ewelina ^[1]; Płonka, Dawid ^[1];

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Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland, Department of Medicine
Department of Chemistry and Physics, Saint Mary's College, Notre Dame, USA
Department of Surgery, Division of Neurosurgery, College of Medicine, University of Saskatchewan, Saskatoon
Institut de Chimie, UMR 7177, CNRS-Université de Strasbourg, Strasbourg, France
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland, Institut de Chimie

The superior Cu( ii ) affinity of human copper transporter 1 (hCtr1) drives copper acquisition from human serum albumin (HSA).

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Sponsoring Organization:: USDOE

OSTI ID:: 1483907

Journal Information:: Metallomics, Journal Name: Metallomics Vol. 10 Journal Issue: 12; ISSN 1756-5901

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Cited by: 28 works

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References (33)

The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1 Kahra, Dana; Kovermann, Michael; Wittung-Stafshede, Pernilla Biophysical Journal, Vol. 110, Issue 1 https://doi.org/10.1016/j.bpj.2015.11.016	journal	January 2016
The Mechanism of Copper Uptake Mediated by Human CTR1: A MUTATIONAL ANALYSIS Eisses, John F.; Kaplan, Jack H. Journal of Biological Chemistry, Vol. 280, Issue 44 https://doi.org/10.1074/jbc.M508822200	journal	August 2005
Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1 Du, Xiubo; Li, Hongyan; Wang, Xinghao Chemical Communications, Vol. 49, Issue 80 https://doi.org/10.1039/c3cc45360j	journal	January 2013
Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O2 Schwab, Stefanie; Shearer, Jason; Conklin, Steven E. Journal of Inorganic Biochemistry, Vol. 158 https://doi.org/10.1016/j.jinorgbio.2015.12.021	journal	May 2016
Structural Insight into Redox Dynamics of Copper Bound N-Truncated Amyloid-β Peptides from in Situ X-ray Absorption Spectroscopy Streltsov, Victor A.; Ekanayake, Ruwini S. K.; Drew, Simon C. Inorganic Chemistry, Vol. 57, Issue 18 https://doi.org/10.1021/acs.inorgchem.8b01255	journal	August 2018
Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease Carboni, Eleonora; Lingor, Paul Metallomics, Vol. 7, Issue 3 https://doi.org/10.1039/C4MT00339J	journal	January 2015
Lysosomal Acidification Mechanisms Mindell, Joseph A. Annual Review of Physiology, Vol. 74, Issue 1 https://doi.org/10.1146/annurev-physiol-012110-142317	journal	March 2012
Oxidative stress and the amyloid beta peptide in Alzheimer’s disease Cheignon, C.; Tomas, M.; Bonnefont-Rousselot, D. Redox Biology, Vol. 14 https://doi.org/10.1016/j.redox.2017.10.014	journal	April 2018
The Cu(II) affinity of the N-terminus of human copper transporter CTR1: Comparison of human and mouse sequences Bossak, Karolina; Drew, Simon C.; Stefaniak, Ewelina Journal of Inorganic Biochemistry, Vol. 182 https://doi.org/10.1016/j.jinorgbio.2018.01.011	journal	May 2018
The Steap proteins are metalloreductases Ohgami, Robert S.; Campagna, Dean R.; McDonald, Alice Blood, Vol. 108, Issue 4 https://doi.org/10.1182/blood-2006-02-003681	journal	August 2006
Cu(II) complexation by “non-coordinating” N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid (HEPES buffer)☆ Sokołowska, Magdalena; Bal, Wojciech Journal of Inorganic Biochemistry, Vol. 99, Issue 8 https://doi.org/10.1016/j.jinorgbio.2005.05.007	journal	August 2005
The N-terminus of hepcidin is a strong and potentially biologically relevant Cu(II) chelator Płonka, Dawid; Bal, Wojciech Inorganica Chimica Acta, Vol. 472 https://doi.org/10.1016/j.ica.2017.06.051	journal	March 2018
Model Peptides Provide New Insights into the Role of Histidine Residues as Potential Ligands in Human Cellular Copper Acquisition via Ctr1 Haas, Kathryn L.; Putterman, Allison B.; White, Daniel R. Journal of the American Chemical Society, Vol. 133, Issue 12 https://doi.org/10.1021/ja108890c	journal	March 2011
Copper-stimulated Endocytosis and Degradation of the Human Copper Transporter, hCtr1 Petris, Michael J.; Smith, Kathryn; Lee, Jaekwon Journal of Biological Chemistry, Vol. 278, Issue 11 https://doi.org/10.1074/jbc.M209455200	journal	December 2002
Identification of Methionine-rich Clusters That Regulate Copper-stimulated Endocytosis of the Human Ctr1 Copper Transporter Guo, Yan; Smith, Kathryn; Lee, Jaekwon Journal of Biological Chemistry, Vol. 279, Issue 17 https://doi.org/10.1074/jbc.M401493200	journal	February 2004
A Functional Role for Aβ in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding Mital, Mariusz; Wezynfeld, Nina E.; Frączyk, Tomasz Angewandte Chemie International Edition, Vol. 54, Issue 36 https://doi.org/10.1002/anie.201502644	journal	July 2015
Uptake of copper from plasma proteins in cells where expression of CTR1 has been modulated Kidane, Theodros Z.; Farhad, Ramin; Lee, Kyoung Jin BioMetals, Vol. 25, Issue 4 https://doi.org/10.1007/s10534-012-9528-8	journal	February 2012
Human serum albumin coordinates Cu(II) at its N-terminal binding site with 1 pM affinity Rózga, Małgorzata; Sokołowska, Magdalena; Protas, Anna Maria JBIC Journal of Biological Inorganic Chemistry, Vol. 12, Issue 6 https://doi.org/10.1007/s00775-007-0244-8	journal	May 2007
Structure and Affinity of Cu(I) Bound to Human Serum Albumin Sendzik, Madison; Pushie, M. Jake; Stefaniak, Ewelina Inorganic Chemistry, Vol. 56, Issue 24 https://doi.org/10.1021/acs.inorgchem.7b02397	journal	November 2017
Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1) Klomp, Adriana E. M.; Tops, Bastiaan B. J.; vandenBERG, Inge E. T. Biochemical Journal, Vol. 364, Issue 2 https://doi.org/10.1042/bj20011803	journal	June 2002
Mechanism of Copper Uptake from Blood Plasma Ceruloplasmin by Mammalian Cells Ramos, Danny; Mar, David; Ishida, Michael PLOS ONE, Vol. 11, Issue 3 https://doi.org/10.1371/journal.pone.0149516	journal	March 2016
How Mammalian Cells Acquire Copper: An Essential but Potentially Toxic Metal Kaplan, Jack H.; Maryon, Edward B. Biophysical Journal, Vol. 110, Issue 1 https://doi.org/10.1016/j.bpj.2015.11.025	journal	January 2016
N-Terminal Cu-Binding Motifs (Xxx-Zzz-His, Xxx-His) and Their Derivatives: Chemistry, Biology and Medicinal Applications Gonzalez, Paulina; Bossak, Karolina; Stefaniak, Ewelina Chemistry - A European Journal, Vol. 24, Issue 32 https://doi.org/10.1002/chem.201705398	journal	March 2018
Sequence-Specific Ni(II)-Dependent Peptide Bond Hydrolysis for Protein Engineering: Reaction Conditions and Molecular Mechanism Kopera, Edyta; Krȩżel, Artur; Protas, Anna Maria Inorganic Chemistry, Vol. 49, Issue 14 https://doi.org/10.1021/ic1005709	journal	July 2010
X-ray and Solution Structures of CuIIGHK and CuIIDAHK Complexes: Influence on Their Redox Properties Hureau, Christelle; Eury, Hélène; Guillot, Régis Chemistry - A European Journal, Vol. 17, Issue 36 https://doi.org/10.1002/chem.201100751	journal	July 2011
Macromolecular ligands of exchangeable copper, zinc and cadmium in human serum Giroux, Eugene L.; Henkin, Robert I. Bioinorganic Chemistry, Vol. 2, Issue 2 https://doi.org/10.1016/S0006-3061(00)80156-8	journal	January 1973
The Yeast Fre1p/Fre2p Cupric Reductases Facilitate Copper Uptake and Are Regulated by the Copper-modulated Mac1p Activator Georgatsou, Elena; Mavrogiannis, Lampros A.; Fragiadakis, George S. Journal of Biological Chemistry, Vol. 272, Issue 21 https://doi.org/10.1074/jbc.272.21.13786	journal	May 1997
Ceruloplasmin and other copper binding components of blood plasma and their functions: an update Linder, M. C. Metallomics, Vol. 8, Issue 9 https://doi.org/10.1039/C6MT00103C	journal	January 2016
Biochemical and Genetic Analyses of Yeast and Human High Affinity Copper Transporters Suggest a Conserved Mechanism for Copper Uptake Puig, Sergi; Lee, Jaekwon; Lau, Miranda Journal of Biological Chemistry, Vol. 277, Issue 29 https://doi.org/10.1074/jbc.M202547200	journal	April 2002
A study of the comparative donor properties to Cu II of the terminal amino and imidazole nitrogens in peptides Pettit, Leslie D.; Pyburn, Simon; Bal, Wojciech Journal of the Chemical Society, Dalton Transactions, Issue 12 https://doi.org/10.1039/dt9900003565	journal	January 1990
Three-dimensional structure of the human copper transporter hCTR1 De Feo, C. J.; Aller, S. G.; Siluvai, G. S. Proceedings of the National Academy of Sciences, Vol. 106, Issue 11 https://doi.org/10.1073/pnas.0810286106	journal	February 2009
EPR Spectroscopy Shows that the Blood Carrier Protein, Human Serum Albumin, Closely Interacts with the N-Terminal Domain of the Copper Transporter, Ctr1 Shenberger, Yulia; Shimshi, Amit; Ruthstein, Sharon The Journal of Physical Chemistry B, Vol. 119, Issue 14 https://doi.org/10.1021/acs.jpcb.5b00091	journal	March 2015
Human Annexins A1, A2, and A8 as Potential Molecular Targets for Ni(II) Ions Wezynfeld, Nina E.; Bossak, Karolina; Goch, Wojciech Chemical Research in Toxicology, Vol. 27, Issue 11 https://doi.org/10.1021/tx500337w	journal	October 2014

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