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Title: Accumulation of persistent tungsten in bone as in situ generated polytungstate

Abstract

Tungsten accumulates in bone but is neither labile nor inert once absorbed. Tungsten’s relatively high cytosolic solubility and availability are problematic given its association with childhood lymphocytic leukemia. In light of tungsten’s technological prevalence, and the increased concern of regulatory agencies, here we characterize the chemical form and localization in mice exposed to tungsten through drinking water. Using X-ray fluorescence spectroscopy, we report accumulation of tungsten in bone tissue with some sites having ~10-fold greater intensities than background levels. The long bone tissue studied includes cortical, cancellous and bone marrow. Persistence of tungsten in cortical bone tissue following removal of the source indicates that it is retained in an insoluble form. The X-ray absorption near-edge structure spectra for tungsten in these tissues indicate that it is no longer in the originally administered form, orthotungstate, but rather resembles the heteropolytungsate species, phosphotungstate.

Authors:
ORCiD logo [1]; ORCiD logo [2];  [1];  [3];  [4];  [5];  [5];  [5];  [1];  [1]
  1. McGill Univ., Montreal, QC (Canada)
  2. McGill Univ., Montreal, QC (Canada); Stellenbosch Univ. (South Africa)
  3. National Tsing Hua Univ., Hsinchu (Taiwan)
  4. Canadian Light Sources, Inc., Saskatoon, SK (Canada)
  5. Brookhaven National Lab. (BNL), Upton, NY (United States)
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1483562
Report Number(s):
BNL-209502-2018-JAAM
Journal ID: ISSN 2399-3669
Grant/Contract Number:  
SC0012704
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Communications Chemistry
Additional Journal Information:
Journal Volume: 1; Journal Issue: 1; Journal ID: ISSN 2399-3669
Publisher:
Springer Nature
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

VanderSchee, Cassidy R., Kuter, David, Bolt, Alicia M., Lo, Feng-Chun, Feng, Renfei, Thieme, Juergen, Chen-Wiegart, Yu-chen Karen, Williams, Garth, Mann, Koren K., and Bohle, D. Scott. Accumulation of persistent tungsten in bone as in situ generated polytungstate. United States: N. p., 2018. Web. doi:10.1038/s42004-017-0007-6.
VanderSchee, Cassidy R., Kuter, David, Bolt, Alicia M., Lo, Feng-Chun, Feng, Renfei, Thieme, Juergen, Chen-Wiegart, Yu-chen Karen, Williams, Garth, Mann, Koren K., & Bohle, D. Scott. Accumulation of persistent tungsten in bone as in situ generated polytungstate. United States. doi:10.1038/s42004-017-0007-6.
VanderSchee, Cassidy R., Kuter, David, Bolt, Alicia M., Lo, Feng-Chun, Feng, Renfei, Thieme, Juergen, Chen-Wiegart, Yu-chen Karen, Williams, Garth, Mann, Koren K., and Bohle, D. Scott. Thu . "Accumulation of persistent tungsten in bone as in situ generated polytungstate". United States. doi:10.1038/s42004-017-0007-6. https://www.osti.gov/servlets/purl/1483562.
@article{osti_1483562,
title = {Accumulation of persistent tungsten in bone as in situ generated polytungstate},
author = {VanderSchee, Cassidy R. and Kuter, David and Bolt, Alicia M. and Lo, Feng-Chun and Feng, Renfei and Thieme, Juergen and Chen-Wiegart, Yu-chen Karen and Williams, Garth and Mann, Koren K. and Bohle, D. Scott},
abstractNote = {Tungsten accumulates in bone but is neither labile nor inert once absorbed. Tungsten’s relatively high cytosolic solubility and availability are problematic given its association with childhood lymphocytic leukemia. In light of tungsten’s technological prevalence, and the increased concern of regulatory agencies, here we characterize the chemical form and localization in mice exposed to tungsten through drinking water. Using X-ray fluorescence spectroscopy, we report accumulation of tungsten in bone tissue with some sites having ~10-fold greater intensities than background levels. The long bone tissue studied includes cortical, cancellous and bone marrow. Persistence of tungsten in cortical bone tissue following removal of the source indicates that it is retained in an insoluble form. The X-ray absorption near-edge structure spectra for tungsten in these tissues indicate that it is no longer in the originally administered form, orthotungstate, but rather resembles the heteropolytungsate species, phosphotungstate.},
doi = {10.1038/s42004-017-0007-6},
journal = {Communications Chemistry},
number = 1,
volume = 1,
place = {United States},
year = {Thu Mar 08 00:00:00 EST 2018},
month = {Thu Mar 08 00:00:00 EST 2018}
}

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