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Title: Final report: The Systems Biology of Protein Acetylation in Fuel-Producing Microorganisms

Abstract

Our goal is to determine how protein acetylation affects metabolism in engineered microorganisms. Lysine acetylation is a common post-translational modification that eukaryotes, archaea, and bacteria employ to regulate protein activity. Multiple studies have recently shown that lysine acetylation predominantly targets metabolic enzymes – in fact, most metabolic enzymes are subject to lysine acetylation. Still, we know very little about lysine acetylation, particularly in the case of bacteria. We hypothesize that bacteria employ lysine acetylation as a global mechanism to regulate metabolism in response to their energy and redox status. Our previous work suggests that lysine acetylation may be an attractive and innovative target for metabolic engineering. We propose to investigate how lysine acetylation affects fuel production in engineered microorganisms. The significance of this work is that it will address a fundamental gap in our understanding of bacterial metabolism and identify new approaches for overcoming the problems associated with the production of advanced biofuels.

Authors:
 [1]
  1. Univ. of Illinois at Urbana-Champaign, Champaign County, IL (United States)
Publication Date:
Research Org.:
University of Illinois at Urbana-Champaign, Champaign County, IL (United States); Idaho National Lab. (INL), Idaho Falls, ID (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23). Biological Systems Science Division
OSTI Identifier:
1483353
Report Number(s):
DOE-UIUC-SC-0012443
DOE Contract Number:  
SC0012443
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Acetylation

Citation Formats

Rao, Christopher. Final report: The Systems Biology of Protein Acetylation in Fuel-Producing Microorganisms. United States: N. p., 2018. Web. doi:10.2172/1483353.
Rao, Christopher. Final report: The Systems Biology of Protein Acetylation in Fuel-Producing Microorganisms. United States. doi:10.2172/1483353.
Rao, Christopher. Tue . "Final report: The Systems Biology of Protein Acetylation in Fuel-Producing Microorganisms". United States. doi:10.2172/1483353. https://www.osti.gov/servlets/purl/1483353.
@article{osti_1483353,
title = {Final report: The Systems Biology of Protein Acetylation in Fuel-Producing Microorganisms},
author = {Rao, Christopher},
abstractNote = {Our goal is to determine how protein acetylation affects metabolism in engineered microorganisms. Lysine acetylation is a common post-translational modification that eukaryotes, archaea, and bacteria employ to regulate protein activity. Multiple studies have recently shown that lysine acetylation predominantly targets metabolic enzymes – in fact, most metabolic enzymes are subject to lysine acetylation. Still, we know very little about lysine acetylation, particularly in the case of bacteria. We hypothesize that bacteria employ lysine acetylation as a global mechanism to regulate metabolism in response to their energy and redox status. Our previous work suggests that lysine acetylation may be an attractive and innovative target for metabolic engineering. We propose to investigate how lysine acetylation affects fuel production in engineered microorganisms. The significance of this work is that it will address a fundamental gap in our understanding of bacterial metabolism and identify new approaches for overcoming the problems associated with the production of advanced biofuels.},
doi = {10.2172/1483353},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {11}
}