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Title: Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates

Abstract

Four potent and selective F-18 labeled S1PR1 radiotracers were radiosynthesized and three of them were able to cross blood–brain-barrier and enter into the brain of nonhuman primates.

Authors:
ORCiD logo [1];  [1]; ORCiD logo [1]; ORCiD logo [1];  [1];  [1]; ORCiD logo [2]; ORCiD logo [1]
  1. Department of Radiology, Washington University School of Medicine, St Louis, USA
  2. Department of Radiology, Washington University School of Medicine, St Louis, USA, Departments of Neurology
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1483021
Grant/Contract Number:  
SC0008432
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Organic & Biomolecular Chemistry
Additional Journal Information:
Journal Name: Organic & Biomolecular Chemistry Journal Volume: 16 Journal Issue: 47; Journal ID: ISSN 1477-0520
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Luo, Zonghua, Han, Junbin, Liu, Hui, Rosenberg, Adam J., Chen, Delphine L., Gropler, Robert J., Perlmutter, Joel S., and Tu, Zhude. Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates. United Kingdom: N. p., 2018. Web. doi:10.1039/C8OB02609B.
Luo, Zonghua, Han, Junbin, Liu, Hui, Rosenberg, Adam J., Chen, Delphine L., Gropler, Robert J., Perlmutter, Joel S., & Tu, Zhude. Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates. United Kingdom. doi:10.1039/C8OB02609B.
Luo, Zonghua, Han, Junbin, Liu, Hui, Rosenberg, Adam J., Chen, Delphine L., Gropler, Robert J., Perlmutter, Joel S., and Tu, Zhude. Wed . "Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates". United Kingdom. doi:10.1039/C8OB02609B.
@article{osti_1483021,
title = {Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates},
author = {Luo, Zonghua and Han, Junbin and Liu, Hui and Rosenberg, Adam J. and Chen, Delphine L. and Gropler, Robert J. and Perlmutter, Joel S. and Tu, Zhude},
abstractNote = {Four potent and selective F-18 labeled S1PR1 radiotracers were radiosynthesized and three of them were able to cross blood–brain-barrier and enter into the brain of nonhuman primates.},
doi = {10.1039/C8OB02609B},
journal = {Organic & Biomolecular Chemistry},
number = 47,
volume = 16,
place = {United Kingdom},
year = {Wed Dec 05 00:00:00 EST 2018},
month = {Wed Dec 05 00:00:00 EST 2018}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on November 15, 2019
Publisher's Accepted Manuscript

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