Dietary nutrient levels alter the metabolism of arginine family amino acids in the conceptus of Huanjiang mini‐pigs
Abstract
Abstract BACKGROUND The arginine family amino acids (AFAAs) exert important roles in the metabolism, growth and development of the conceptus. However, to date, few studies have investigated the effects of maternal nutrient levels on the concentrations and metabolism of AFAAs in the conceptus. RESULTS Compared to low nutrient diets, high nutrient diets increased ( P < 0.05) the concentrations of citrulline and proline (Pro) in plasma; the concentrations of arginine, glutamine, Pro and ornithine (Orn) in the amniotic fluid; and the concentrations of all detected AFAAs in the allantoic fluid, which were most pronounced on day 45 of pregnancy. High nutrient diets upregulated ( P < 0.05) mRNA expression of arginase I ( Arg I ), Pro oxidase and spermidine synthetase ( SRM ) in the fetal placenta, as well as Arg II , SRM and spermine synthetase ( SMS ) expression in the fetal liver (most pronounced on day 45 of pregnancy). The same effect was observed for mRNA expression of NO synthase and Orn aminotransferase ( OAT ), mainly on day 110 of pregnancy, and for mRNA expression of Arg I , Arg II , OAT , Orn decarboxylase and SMS throughout pregnancy. High nutrient diets upregulated ( P < 0.05)more »
- Authors:
-
- Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process Changsha China, Key Laboratory of Agro‐ecological Processes in Subtropical Region Institute of Subtropical Agriculture, Chinese Academy of Sciences Changsha China, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production Changsha China, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South‐Central Ministry of Agriculture Changsha China, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production Changsha China
- University of Chinese Academy of Sciences Beijing China
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1482845
- Resource Type:
- Journal Article: Publisher's Accepted Manuscript
- Journal Name:
- Journal of the Science of Food and Agriculture
- Additional Journal Information:
- Journal Name: Journal of the Science of Food and Agriculture Journal Volume: 99 Journal Issue: 5; Journal ID: ISSN 0022-5142
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- United Kingdom
- Language:
- English
Citation Formats
Duan, Yehui, Zhao, Yue, Zhu, Qian, Cai, Qiaoli, Li, Huawei, Yin, Yulong, Wang, Zhanbin, and Kong, Xiangfeng. Dietary nutrient levels alter the metabolism of arginine family amino acids in the conceptus of Huanjiang mini‐pigs. United Kingdom: N. p., 2018.
Web. doi:10.1002/jsfa.9405.
Duan, Yehui, Zhao, Yue, Zhu, Qian, Cai, Qiaoli, Li, Huawei, Yin, Yulong, Wang, Zhanbin, & Kong, Xiangfeng. Dietary nutrient levels alter the metabolism of arginine family amino acids in the conceptus of Huanjiang mini‐pigs. United Kingdom. https://doi.org/10.1002/jsfa.9405
Duan, Yehui, Zhao, Yue, Zhu, Qian, Cai, Qiaoli, Li, Huawei, Yin, Yulong, Wang, Zhanbin, and Kong, Xiangfeng. 2018.
"Dietary nutrient levels alter the metabolism of arginine family amino acids in the conceptus of Huanjiang mini‐pigs". United Kingdom. https://doi.org/10.1002/jsfa.9405.
@article{osti_1482845,
title = {Dietary nutrient levels alter the metabolism of arginine family amino acids in the conceptus of Huanjiang mini‐pigs},
author = {Duan, Yehui and Zhao, Yue and Zhu, Qian and Cai, Qiaoli and Li, Huawei and Yin, Yulong and Wang, Zhanbin and Kong, Xiangfeng},
abstractNote = {Abstract BACKGROUND The arginine family amino acids (AFAAs) exert important roles in the metabolism, growth and development of the conceptus. However, to date, few studies have investigated the effects of maternal nutrient levels on the concentrations and metabolism of AFAAs in the conceptus. RESULTS Compared to low nutrient diets, high nutrient diets increased ( P < 0.05) the concentrations of citrulline and proline (Pro) in plasma; the concentrations of arginine, glutamine, Pro and ornithine (Orn) in the amniotic fluid; and the concentrations of all detected AFAAs in the allantoic fluid, which were most pronounced on day 45 of pregnancy. High nutrient diets upregulated ( P < 0.05) mRNA expression of arginase I ( Arg I ), Pro oxidase and spermidine synthetase ( SRM ) in the fetal placenta, as well as Arg II , SRM and spermine synthetase ( SMS ) expression in the fetal liver (most pronounced on day 45 of pregnancy). The same effect was observed for mRNA expression of NO synthase and Orn aminotransferase ( OAT ), mainly on day 110 of pregnancy, and for mRNA expression of Arg I , Arg II , OAT , Orn decarboxylase and SMS throughout pregnancy. High nutrient diets upregulated ( P < 0.05) mRNA expression of Y + L‐type amino acid transporter ( LAT ) and cationic amino acid transporter 1 ( CAT1 ) in the fetal jejunum throughout pregnancy. Dietary treatments did not affect ( P > 0.05) mRNA expression of Y + LAT1 , sodium‐coupled neutral amino acid transporter 2 ( SNAT2 ) and CAT1 in the fetal placenta, skeletal muscle and colon. CONCLUSION High nutrient diets increased the concentration and transport of AFAAs in the mothers and conceptus, which likely improves growth and development of the conceptus. © 2018 Society of Chemical Industry},
doi = {10.1002/jsfa.9405},
url = {https://www.osti.gov/biblio/1482845},
journal = {Journal of the Science of Food and Agriculture},
issn = {0022-5142},
number = 5,
volume = 99,
place = {United Kingdom},
year = {Tue Nov 20 00:00:00 EST 2018},
month = {Tue Nov 20 00:00:00 EST 2018}
}
Web of Science
Works referenced in this record:
Maternal Dietary Protein Deficiency Decreases Amino Acid Concentrations in Fetal Plasma and Allantoic Fluid of Pigs
journal, May 1998
- Wu, Guoyao; Pond, Wilson G.; Ott, Troy
- The Journal of Nutrition, Vol. 128, Issue 5
Polyamine Synthesis from Proline in the Developing Porcine Placenta1
journal, April 2005
- Wu, Guoyao; Bazer, Fuller W.; Hu, Jianbo
- Biology of Reproduction, Vol. 72, Issue 4
Postpartum hypophagia in primiparous sows: I. Effects of gestation feeding level on feed intake, feeding behavior, and plasma metabolite concentrations during lactation2
journal, February 1994
- Weldon, W. C.; Lewis, A. J.; Louis, G. F.
- Journal of Animal Science, Vol. 72, Issue 2
Polyamines: Mysterious Modulators of Cellular Functions
journal, May 2000
- Igarashi, Kazuei; Kashiwagi, Keiko
- Biochemical and Biophysical Research Communications, Vol. 271, Issue 3
BOARD-INVITED REVIEW: Intrauterine growth retardation: Implications for the animal sciences1
journal, September 2006
- Wu, G.; Bazer, F. W.; Wallace, J. M.
- Journal of Animal Science, Vol. 84, Issue 9
Effect of nutrition on embryonal mortality in gilts: association with progesterone.
journal, January 1996
- Jindal, R.; Cosgrove, J. R.; Aherne, F. X.
- Journal of Animal Science, Vol. 74, Issue 3
Maternal Dietary Protein Deficiency Decreases Nitric Oxide Synthase and Ornithine Decarboxylase Activities in Placenta and Endometrium of Pigs During Early Gestation
journal, December 1998
- Wu, Guoyao; Pond, Wilson G.; Flynn, Sean P.
- The Journal of Nutrition, Vol. 128, Issue 12
Recent advances in arginine metabolism: roles and regulation of the arginases
journal, July 2009
- Morris Jr, Sidney M.
- British Journal of Pharmacology, Vol. 157, Issue 6
Arginine metabolism: nitric oxide and beyond
journal, November 1998
- Wu, Guoyao; Morris, Sidney M.
- Biochemical Journal, Vol. 336, Issue 1
Dietary Supplementation with Acanthopanax senticosus Extract Modulates Cellular and Humoral Immunity in Weaned Piglets
journal, August 2007
- Kong, Xiangfeng; Yin, Yulong; Wu, Guoyao
- Asian-Australasian Journal of Animal Sciences, Vol. 20, Issue 9
Effects of dietary lysine levels on plasma free amino acid profile in late-stage finishing pigs
journal, June 2016
- Regmi, Naresh; Wang, Taiji; Crenshaw, Mark A.
- SpringerPlus, Vol. 5, Issue 1
Proline metabolism in the conceptus: implications for fetal growth and development
journal, March 2008
- Wu, G.; Bazer, F. W.; Datta, S.
- Amino Acids, Vol. 35, Issue 4
Dietary l-Arginine Supplementation Enhances the Reproductive Performance of Gilts
journal, March 2007
- Mateo, Ronaldo D.; Wu, Guoyao; Bazer, Fuller W.
- The Journal of Nutrition, Vol. 137, Issue 3
Effects of dietary nutrient levels on microbial community composition and diversity in the ileal contents of pregnant Huanjiang mini-pigs
journal, February 2017
- Ji, Yujiao; Kong, Xiangfeng; Li, Huawei
- PLOS ONE, Vol. 12, Issue 2
Myokine interleukin-15 expression profile is different in suckling and weaning piglets
journal, March 2015
- Duan, Yehui; Li, Fengna; Tan, Bie
- Animal Nutrition, Vol. 1, Issue 1
Dietary Arginine Supplementation during Early Pregnancy Enhances Embryonic Survival in Rats
journal, August 2008
- Zeng, Xiangfang; Wang, Fenglai; Fan, Xia
- The Journal of Nutrition, Vol. 138, Issue 8
Angiogenesis in the Placenta1
journal, April 2001
- Reynolds, Lawrence P.; Redmer, Dale A.
- Biology of Reproduction, Vol. 64, Issue 4
Arginine Nutrition and Cardiovascular Function
journal, November 2000
- Wu, Guoyao; Meininger, Cynthia J.
- The Journal of Nutrition, Vol. 130, Issue 11
Developmental Changes in Polyamine Levels and Synthesis in the Ovine Conceptus1
journal, November 2003
- Kwon, Hyukjung; Wu, Guoyao; Bazer, Fuller W.
- Biology of Reproduction, Vol. 69, Issue 5
Developmental Changes of Amino Acids in Ovine Fetal Fluids1
journal, May 2003
- Kwon, Hyukjung; Spencer, Thomas E.; Bazer, Fuller W.
- Biology of Reproduction, Vol. 68, Issue 5
Development of ingestive behavior
journal, April 1998
- Ross, Michael G.; Nijland, Mark J. M.
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 274, Issue 4
Impacts of Birth Weight on Plasma, Liver and Skeletal Muscle Neutral Amino Acid Profiles and Intestinal Amino Acid Transporters in Suckling Huanjiang Mini-Piglets
journal, December 2012
- Yang, Huansheng; Fu, Dezhi; Shao, Hua
- PLoS ONE, Vol. 7, Issue 12
Dietary l-arginine supplementation enhances placental growth and reproductive performance in sows
journal, June 2011
- Gao, Kaiguo; Jiang, Zongyong; Lin, Yingcai
- Amino Acids, Vol. 42, Issue 6
Important roles for the arginine family of amino acids in swine nutrition and production
journal, October 2007
- Wu, Guoyao; Bazer, Fuller W.; Davis, Teresa A.
- Livestock Science, Vol. 112, Issue 1-2
Possible mechanisms underlying pregnancy-induced changes in uterine artery endothelial function
journal, February 2003
- Bird, Ian M.; Zhang, Lubo; Magness, Ronald R.
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 284, Issue 2
Impacts of arginine nutrition on embryonic and fetal development in mammals
journal, June 2013
- Wu, Guoyao; Bazer, Fuller W.; Satterfield, M. Carey
- Amino Acids, Vol. 45, Issue 2
Intrauterine Growth Restriction Affects the Proteomes of the Small Intestine, Liver, and Skeletal Muscle in Newborn Pigs
journal, January 2008
- Wang, Junjun; Chen, Lixiang; Li, Defa
- The Journal of Nutrition, Vol. 138, Issue 1
Maternal Nutrient Restriction Reduces Concentrations of Amino Acids and Polyamines in Ovine Maternal and Fetal Plasma and Fetal Fluids1
journal, September 2004
- Kwon, Hyukjung; Ford, Stephen P.; Bazer, Fuller W.
- Biology of Reproduction, Vol. 71, Issue 3