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Title: Crimping-induced structural gradients explain the lasting strength of poly L-lactide bioresorbable vascular scaffolds during hydrolysis

Abstract

Biodegradable polymers open the way to treatment of heart disease using transient implants (bioresorbable vascular scaffolds, BVSs) that overcome the most serious complication associated with permanent metal stents—late stent thrombosis. Here, we address the long-standing paradox that the clinically approved BVS maintains its radial strength even after 9 mo of hydrolysis, which induces a ~40% decrease in the poly L-lactide molecular weight (Mn). X-ray microdiffraction evidence of nonuniform hydrolysis in the scaffold reveals that regions subjected to tensile stress during crimping develop a microstructure that provides strength and resists hydrolysis. These beneficial morphological changes occur where they are needed most—where stress is localized when a radial load is placed on the scaffold. We hypothesize that the observed decrease in Mn reflects the majority of the material, which is undeformed during crimping. Thus, the global measures of degradation may be decoupled from the localized, degradation-resistant regions that confer the ability to support the artery for the first several months after implantation.

Authors:
ORCiD logo [1]; ORCiD logo [2];  [1];  [3];  [4];  [1]
  1. California Institute of Technology (CalTech), Pasadena, CA (United States)
  2. California Institute of Technology (CalTech), Pasadena, CA (United States); ENEA Centro Ricerche Portici (Italy)
  3. Abbott Vascular, Santa Clara, CA (United States)
  4. Abbott Vascular, Santa Clara, CA (United States); Gilead Sciences, Inc., Foster City, CA (United States)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22). Scientific User Facilities Division; National Inst. of Health
OSTI Identifier:
1482248
Grant/Contract Number:  
AC02-06CH11357; F31HL137308
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Additional Journal Information:
Journal Volume: 115; Journal Issue: 41; Journal ID: ISSN 0027-8424
Publisher:
National Academy of Sciences
Country of Publication:
United States
Language:
ENGLISH
Subject:
59 BASIC BIOLOGICAL SCIENCES; PLLA; hydrolysis; coronary heart disease; BVS; X-ray microdiffraction

Citation Formats

Ramachandran, Karthik, Di Luccio, Tiziana, Ailianou, Artemis, Kossuth, Mary Beth, Oberhauser, James P., and Kornfield, Julia A. Crimping-induced structural gradients explain the lasting strength of poly L-lactide bioresorbable vascular scaffolds during hydrolysis. United States: N. p., 2018. Web. doi:10.1073/pnas.1807347115.
Ramachandran, Karthik, Di Luccio, Tiziana, Ailianou, Artemis, Kossuth, Mary Beth, Oberhauser, James P., & Kornfield, Julia A. Crimping-induced structural gradients explain the lasting strength of poly L-lactide bioresorbable vascular scaffolds during hydrolysis. United States. doi:10.1073/pnas.1807347115.
Ramachandran, Karthik, Di Luccio, Tiziana, Ailianou, Artemis, Kossuth, Mary Beth, Oberhauser, James P., and Kornfield, Julia A. Mon . "Crimping-induced structural gradients explain the lasting strength of poly L-lactide bioresorbable vascular scaffolds during hydrolysis". United States. doi:10.1073/pnas.1807347115. https://www.osti.gov/servlets/purl/1482248.
@article{osti_1482248,
title = {Crimping-induced structural gradients explain the lasting strength of poly L-lactide bioresorbable vascular scaffolds during hydrolysis},
author = {Ramachandran, Karthik and Di Luccio, Tiziana and Ailianou, Artemis and Kossuth, Mary Beth and Oberhauser, James P. and Kornfield, Julia A.},
abstractNote = {Biodegradable polymers open the way to treatment of heart disease using transient implants (bioresorbable vascular scaffolds, BVSs) that overcome the most serious complication associated with permanent metal stents—late stent thrombosis. Here, we address the long-standing paradox that the clinically approved BVS maintains its radial strength even after 9 mo of hydrolysis, which induces a ~40% decrease in the poly L-lactide molecular weight (Mn). X-ray microdiffraction evidence of nonuniform hydrolysis in the scaffold reveals that regions subjected to tensile stress during crimping develop a microstructure that provides strength and resists hydrolysis. These beneficial morphological changes occur where they are needed most—where stress is localized when a radial load is placed on the scaffold. We hypothesize that the observed decrease in Mn reflects the majority of the material, which is undeformed during crimping. Thus, the global measures of degradation may be decoupled from the localized, degradation-resistant regions that confer the ability to support the artery for the first several months after implantation.},
doi = {10.1073/pnas.1807347115},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
issn = {0027-8424},
number = 41,
volume = 115,
place = {United States},
year = {2018},
month = {9}
}

Journal Article:
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