skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Spatial distribution of marker gene activity in the mouse lung during alveolarization

Abstract

Here, this data is a curated collection of visual images of gene expression patterns from the pre- and post-natal mouse lung, accompanied by associated mRNA probe sequences and RNA-Seq expression profiles. Mammalian lungs undergo significant growth and cellular differentiation before and after the transition to breathing air. Documenting normal lung development is an important step in understanding abnormal lung development, as well as the challenges faced during a preterm birth. Images in this dataset indicate the spatial distribution of mRNA transcripts for over 500 different genes that are active during lung development, as initially determined via RNA-Seq. Images were systematically acquired using high-throughput in situ hybridization with non-radioactive digoxigenin-labeled mRNA probes across mouse lungs from developmental time points E16.5, E18.5, P7, and P28.

Authors:
 [1];  [2];  [3];  [4];  [4];  [1];  [1];  [5];  [5];  [2];  [6];  [6];  [7];  [7];  [8];  [8];  [8];  [2]
  1. Baylor College of Medicine, Houston, TX (United States); Jan and Dan Duncan Neurological Research Institute at Texas Children׳s Hospital, Houston, TX (United States)
  2. The Univ. of Texas at Austin, Austin, TX (United States)
  3. Harvard Medical School, Boston, MA (United States)
  4. Cincinnati Children׳s Hospital Medical Center, Cincinnati, OH (United States)
  5. RTI International, Research Triangle Park, NC (United States)
  6. Univ. of Alabama at Birmingham, Birmingham, AL (United States)
  7. Yale Univ., New Haven, CT (United States)
  8. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1482211
Grant/Contract Number:  
U01 HL122703; S10 OD016167; AC05-76RL01830
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Data in Brief
Additional Journal Information:
Journal Volume: 22; Journal ID: ISSN 2352-3409
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Ljungberg, M. Cecilia, Sadi, Mayce, Wang, Yunguan, Aronow, Bruce, Xu, Yan, Kao, Rong J., Liu, Ying, Gaddis, Nathan, Ardini-Poleske, Maryanne E., Umrod, Tipparat, Ambalavanan, Namasivayam, Nicola, Teodora, Kaminski, Naftali, Ahangari, Farida, Sontag, Ryan, Corley, Richard A., Ansong, Charles, and Carson, James P.. Spatial distribution of marker gene activity in the mouse lung during alveolarization. United States: N. p., 2018. Web. doi:10.1016/j.dib.2018.10.150.
Ljungberg, M. Cecilia, Sadi, Mayce, Wang, Yunguan, Aronow, Bruce, Xu, Yan, Kao, Rong J., Liu, Ying, Gaddis, Nathan, Ardini-Poleske, Maryanne E., Umrod, Tipparat, Ambalavanan, Namasivayam, Nicola, Teodora, Kaminski, Naftali, Ahangari, Farida, Sontag, Ryan, Corley, Richard A., Ansong, Charles, & Carson, James P.. Spatial distribution of marker gene activity in the mouse lung during alveolarization. United States. doi:10.1016/j.dib.2018.10.150.
Ljungberg, M. Cecilia, Sadi, Mayce, Wang, Yunguan, Aronow, Bruce, Xu, Yan, Kao, Rong J., Liu, Ying, Gaddis, Nathan, Ardini-Poleske, Maryanne E., Umrod, Tipparat, Ambalavanan, Namasivayam, Nicola, Teodora, Kaminski, Naftali, Ahangari, Farida, Sontag, Ryan, Corley, Richard A., Ansong, Charles, and Carson, James P.. Sat . "Spatial distribution of marker gene activity in the mouse lung during alveolarization". United States. doi:10.1016/j.dib.2018.10.150. https://www.osti.gov/servlets/purl/1482211.
@article{osti_1482211,
title = {Spatial distribution of marker gene activity in the mouse lung during alveolarization},
author = {Ljungberg, M. Cecilia and Sadi, Mayce and Wang, Yunguan and Aronow, Bruce and Xu, Yan and Kao, Rong J. and Liu, Ying and Gaddis, Nathan and Ardini-Poleske, Maryanne E. and Umrod, Tipparat and Ambalavanan, Namasivayam and Nicola, Teodora and Kaminski, Naftali and Ahangari, Farida and Sontag, Ryan and Corley, Richard A. and Ansong, Charles and Carson, James P.},
abstractNote = {Here, this data is a curated collection of visual images of gene expression patterns from the pre- and post-natal mouse lung, accompanied by associated mRNA probe sequences and RNA-Seq expression profiles. Mammalian lungs undergo significant growth and cellular differentiation before and after the transition to breathing air. Documenting normal lung development is an important step in understanding abnormal lung development, as well as the challenges faced during a preterm birth. Images in this dataset indicate the spatial distribution of mRNA transcripts for over 500 different genes that are active during lung development, as initially determined via RNA-Seq. Images were systematically acquired using high-throughput in situ hybridization with non-radioactive digoxigenin-labeled mRNA probes across mouse lungs from developmental time points E16.5, E18.5, P7, and P28.},
doi = {10.1016/j.dib.2018.10.150},
journal = {Data in Brief},
issn = {2352-3409},
number = ,
volume = 22,
place = {United States},
year = {2018},
month = {11}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Save / Share: