skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Methods for the selective detection of alkyne-presenting molecules and related compositions and systems


Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems.

Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
OSTI Identifier:
Patent Number(s):
Application Number:
Lawrence Livermore National Security, LLC (Livermore, CA)
DOE Contract Number:  
Resource Type:
Resource Relation:
Patent File Date: 2014 Mar 07
Country of Publication:
United States

Citation Formats

Valdez, Carlos A., and Williams, Audrey M. Methods for the selective detection of alkyne-presenting molecules and related compositions and systems. United States: N. p., 2018. Web.
Valdez, Carlos A., & Williams, Audrey M. Methods for the selective detection of alkyne-presenting molecules and related compositions and systems. United States.
Valdez, Carlos A., and Williams, Audrey M. Tue . "Methods for the selective detection of alkyne-presenting molecules and related compositions and systems". United States.
title = {Methods for the selective detection of alkyne-presenting molecules and related compositions and systems},
author = {Valdez, Carlos A. and Williams, Audrey M.},
abstractNote = {Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {9}


Save / Share:

Works referenced in this record:

Azidiniumsalze. 7. Mitteilung [1]. Synthese von 1-Äthyl-2-azido-6-X-chinolinium-fluoroboraten
journal, January 1970

Synthesis of ferrocene-labelled steroid derivatives via homogeneous catalytic methods
journal, November 2012

Synthesis of ferrocene-functionalized monomers for biodegradable polymer formation
journal, January 2014

  • Upton, Brianna M.; Gipson, Raymond M.; Duhović, Selma
  • Inorganic Chemistry Frontiers, Vol. 1, Issue 3, p. 271-277
  • DOI: 10.1039/c3qi00041a

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
journal, September 2009

  • Sletten, Ellen M.; Bertozzi, Carolyn R.
  • Angewandte Chemie International Edition, Vol. 48, Issue 38, p. 6974-6998
  • DOI: 10.1002/anie.200900942

Chemical remodelling of cell surfaces in living animals
journal, August 2004

  • Prescher, Jennifer A.; Dube, Danielle H.; Bertozzi, Carolyn R.
  • Nature, Vol. 430, Issue 7002, p. 873-877
  • DOI: 10.1038/nature02791

Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo
journal, August 2006

  • Sawa, M.; Hsu, T.-L.; Itoh, T.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 33, p. 12371-12376
  • DOI: 10.1073/pnas.0605418103

Copper-free click chemistry for dynamic in vivo imaging
journal, October 2007

  • Baskin, J. M.; Prescher, J. A.; Laughlin, S. T.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 43, p. 16793-16797
  • DOI: 10.1073/pnas.0707090104

Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides
journal, November 2005

  • Zhang, Li; Chen, Xinguo; Xue, Peng
  • Journal of the American Chemical Society, Vol. 127, Issue 46, p. 15998-15999
  • DOI: 10.1021/ja054114s

Direct sub-ppt detection of the endocrine disruptor ethinylestradiol in water with a chemiluminescence enzyme-linked immunosorbent assay
journal, October 2005

  • Schneider, Christian; Schöler, Heinz F.; Schneider, Rudolf J.
  • Analytica Chimica Acta, Vol. 551, Issue 1-2, p. 92-97
  • DOI: 10.1016/j.aca.2005.07.018

A Fluorogenic 1,3-Dipolar Cycloaddition Reaction of 3-Azidocoumarins and Acetylenes
journal, November 2004

  • Sivakumar, Krishnamoorthy; Xie, Fang; Cash, Brandon M.
  • Organic Letters, Vol. 6, Issue 24, p. 4603-4606
  • DOI: 10.1021/ol047955x

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes
journal, July 2002

Peptidotriazoles on Solid Phase  [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides
journal, May 2002

  • Tornøe, Christian W.; Christensen, Caspar; Meldal, Morten
  • The Journal of Organic Chemistry, Vol. 67, Issue 9, p. 3057-3064
  • DOI: 10.1021/jo011148j

Are Fluorescence Quantum Yields So Tricky to Measure? A Demonstration Using Familiar Stationery Products
journal, September 1999

  • Fery-Forgues, Suzanne; Lavabre, Dominique
  • Journal of Chemical Education, Vol. 76, Issue 9, p. 1260
  • DOI: 10.1021/ed076p1260

Analytical Methods for Detection of Selected Estrogenic Compounds in Aqueous Mixtures
journal, August 1999

  • Snyder, Shane A.; Keith, Timothy L.; Verbrugge, David A.
  • Environmental Science & Technology, Vol. 33, Issue 16, p. 2814-2820
  • DOI: 10.1021/es981294f

Building scientific consensus on endocrine disruptors
journal, January 1998

Kinetic Evidence for the Formation of Azene (Electron-deficient Nitrogen) Intermediates from Aryl Azides
journal, February 1962

  • Smith, Peter A. S.; Hall, J. Herbert.
  • Journal of the American Chemical Society, Vol. 84, Issue 3, p. 480-485
  • DOI: 10.1021/ja00862a032

journal, February 1961

Water Analysis: Emerging Contaminants and Current Issues
journal, June 2009

  • Richardson, Susan D.
  • Analytical Chemistry, Vol. 81, Issue 12, p. 4645-4677
  • DOI: 10.1021/ac9008012

Design and Synthesis of a Highly Sensitive Off-On Fluorescent Chemosensor for Zinc Ions Utilizing Internal Charge Transfer
journal, January 2010

  • Hanaoka, Kenjiro; Muramatsu, Yasuaki; Urano, Yasuteru
  • Chemistry - A European Journal, Vol. 16, Issue 2, p. 568-572
  • DOI: 10.1002/chem.200901591

Modified paramagnetic beads in a microfluidic system for the determination of ethinylestradiol (EE2) in river water samples
journal, February 2010

  • Martínez, Noelia A.; Schneider, Rudolf J.; Messina, Germán A.
  • Biosensors and Bioelectronics, Vol. 25, Issue 6, p. 1376-1381
  • DOI: 10.1016/j.bios.2009.10.031

Exposure assessment of 17α‐ethinylestradiol in surface waters of the United States and Europe
journal, July 2009

  • Hannah, Robert; D'Aco, Vincent J.; Anderson, Paul D.
  • Environmental Toxicology and Chemistry, Vol. 28, Issue 12, p, 2725-2732
  • DOI: 10.1897/08-622.1

Derivatization for Electrospray Ionization Mass Spectrometry. 3. Electrochemically Ionizable Derivatives
journal, April 1998

  • Van Berkel, Gary J.; Quirke, J. Martin E.; Tigani, Rudolfo A.
  • Analytical Chemistry, Vol. 70, Issue 8, p. 1544-1554
  • DOI: 10.1021/ac971348o

Derivatization of neutral steroids to enhance their detection characteristics in liquid chromatography–mass spectrometry
journal, February 2004

  • Higashi, Tatsuya; Shimada, Kazutake
  • Analytical and Bioanalytical Chemistry, Vol. 378, Issue 4, p. 875-882
  • DOI: 10.1007/s00216-003-2252-z

Determination of Estrogens in Sludge and Sediments by Liquid Extraction and GC/MS/MS
journal, July 2002

  • Ternes, Thomas A.; Andersen, Henrik; Gilberg, Daniel
  • Analytical Chemistry, Vol. 74, Issue 14, p. 3498-3504
  • DOI: 10.1021/ac015717z

Direct conversion of activated alcohols to azides using diphenyl phosphorazidate. A practical alternative to Mitsunobu conditions
journal, October 1993

  • Thompson, Andrew S.; Humphrey, Guy R.; DeMarco, Anthony M.
  • The Journal of Organic Chemistry, Vol. 58, Issue 22, p. 5886-5888
  • DOI: 10.1021/jo00074a008

Practical Synthesis of Amides from In Situ Generated Copper(I) Acetylides and Sulfonyl Azides
journal, May 2006

  • Cassidy, Michael P.; Raushel, Jessica; Fokin, Valery V.
  • Angewandte Chemie International Edition, Vol. 45, Issue 19, p. 3154-3157
  • DOI: 10.1002/anie.200503805

An improved method for the synthesis of α-diazo ketones
journal, March 1990

  • Danheiser, Rick L.; Miller, Raymond F.; Brisbois, Ronald G.
  • The Journal of Organic Chemistry, Vol. 55, Issue 6, p. 1959-1964
  • DOI: 10.1021/jo00293a053

Environmentally Relevant Concentrations of 17α-Ethinylestradiol (EE2) Interfere With the Growth Hormone (GH)/Insulin-Like Growth Factor (IGF)-I System in Developing Bony Fish
journal, July 2008

  • Shved, Natallia; Berishvili, Giorgi; Baroiller, Jean-François
  • Toxicological Sciences, Vol. 106, Issue 1, p. 93-102
  • DOI: 10.1093/toxsci/kfn150

Ferrocene-based derivatization in analytical chemistry
journal, October 2007

  • Seiwert, Bettina; Karst, Uwe
  • Analytical and Bioanalytical Chemistry, Vol. 390, Issue 1, p. 181-200
  • DOI: 10.1007/s00216-007-1639-7

Ferrocene-Based Electroactive Derivatizing Reagents for the Rapid Selective Screening of Alcohols and Phenols in Natural Product Mixtures Using Electrospray−Tandem Mass Spectrometry
journal, February 2000

  • Quirke, J. Martin E.; Hsu, Ya-Li; Van Berkel, Gary J.
  • Journal of Natural Products, Vol. 63, Issue 2, p. 230-237
  • DOI: 10.1021/np990407l

Determination of Endocrine-Disrupting Phenolic Compounds and Estrogens in Surface and Drinking Water by HRGC−(NCI)−MS in the Picogram per Liter Range
journal, August 2001

  • Kuch, Holger M.; Ballschmiter, Karlheinz
  • Environmental Science & Technology, Vol. 35, Issue 15, p. 3201-3206
  • DOI: 10.1021/es010034m

Surface-Enhanced Raman Scattering Spectroscopic Study of 17α-Ethinylestradiol on Silver Colloid and in Glass-Deposited Ag-17α-Ethinylestradiol Film
journal, May 1994

  • Barnett, Steven M.; Vlckova, Blanka.; Butler, Ian S.
  • Analytical Chemistry, Vol. 66, Issue 10, p. 1762-1765
  • DOI: 10.1021/ac00082a026

Preforming ions in solution via charge-transfer complexation for analysis by electrospray ionization mass spectrometry
journal, September 1991

  • Van Berkel, Gary J.; McLuckey, Scott A.; Glish, Gary L.
  • Analytical Chemistry, Vol. 63, Issue 18, p. 2064-2068
  • DOI: 10.1021/ac00018a032

Micelle-induced multiple performance improvement of fluorescent probes for H2S detection
journal, March 2013

Fate of Alkylbenzenesulfonates and Dialkyltetralinsulfonates in Sewage-Contaminated Groundwater
journal, June 1992

  • Field, Jennifer A.; Barber, Larry B.; Thurman, E. Michael
  • Environmental Science & Technology, Vol. 26, Issue 6, p. 1140-1148
  • DOI: 10.1021/es50002a600