skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy

Authors:
; ; ; ; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NIHOTHER
OSTI Identifier:
1481299
Resource Type:
Journal Article
Journal Name:
Journal of Biological Chemistry
Additional Journal Information:
Journal Volume: 292; Journal Issue: 27; Journal ID: ISSN 0021-9258
Publisher:
American Society for Biochemistry and Molecular Biology
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Taylor, Alexander B., Roberts, Kenneth M., Cao, Xiaohang, Clark, Nathaniel E., Holloway, Stephen P., Donati, Enrica, Polcaro, Chiara M., Pica-Mattoccia, Livia, Tarpley, Reid S., McHardy, Stanton F., Cioli, Donato, LoVerde, Philip T., Fitzpatrick, Paul F., and Hart, P. John. Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy. United States: N. p., 2017. Web. doi:10.1074/jbc.M116.766527.
Taylor, Alexander B., Roberts, Kenneth M., Cao, Xiaohang, Clark, Nathaniel E., Holloway, Stephen P., Donati, Enrica, Polcaro, Chiara M., Pica-Mattoccia, Livia, Tarpley, Reid S., McHardy, Stanton F., Cioli, Donato, LoVerde, Philip T., Fitzpatrick, Paul F., & Hart, P. John. Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy. United States. doi:10.1074/jbc.M116.766527.
Taylor, Alexander B., Roberts, Kenneth M., Cao, Xiaohang, Clark, Nathaniel E., Holloway, Stephen P., Donati, Enrica, Polcaro, Chiara M., Pica-Mattoccia, Livia, Tarpley, Reid S., McHardy, Stanton F., Cioli, Donato, LoVerde, Philip T., Fitzpatrick, Paul F., and Hart, P. John. Tue . "Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy". United States. doi:10.1074/jbc.M116.766527.
@article{osti_1481299,
title = {Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy},
author = {Taylor, Alexander B. and Roberts, Kenneth M. and Cao, Xiaohang and Clark, Nathaniel E. and Holloway, Stephen P. and Donati, Enrica and Polcaro, Chiara M. and Pica-Mattoccia, Livia and Tarpley, Reid S. and McHardy, Stanton F. and Cioli, Donato and LoVerde, Philip T. and Fitzpatrick, Paul F. and Hart, P. John},
abstractNote = {},
doi = {10.1074/jbc.M116.766527},
journal = {Journal of Biological Chemistry},
issn = {0021-9258},
number = 27,
volume = 292,
place = {United States},
year = {2017},
month = {5}
}

Works referenced in this record:

Antischistosomal drugs: Past, present … and future?
journal, January 1995


Crystal structure of estrogen sulphotransferase
journal, November 1997

  • Kakuta, Yoshimitsu; Pedersen, Lee G.; Carter, Charles W.
  • Nature Structural & Molecular Biology, Vol. 4, Issue 11
  • DOI: 10.1038/nsb1197-904

A Modular Set of Prokaryotic and Eukaryotic Expression Vectors
journal, January 2000


Snapshot of a Michaelis complex in a sulfuryl transfer reaction: Crystal structure of a mouse sulfotransferase, mSULT1D1, complexed with donor substrate and accepter substrate
journal, May 2009

  • Teramoto, Takamasa; Sakakibara, Yoichi; Liu, Ming-Cheh
  • Biochemical and Biophysical Research Communications, Vol. 383, Issue 1
  • DOI: 10.1016/j.bbrc.2009.03.146

New approaches for understanding mechanisms of drug resistance in schistosomes
journal, April 2013


Hycanthone Resistance: Development in Schistosoma mansoni
journal, June 1971


TopDraw: a sketchpad for protein structure topology cartoons
journal, January 2003


Characterization of Unstable Products of Flavin- and Pterin-Dependent Enzymes by Continuous-Flow Mass Spectrometry
journal, April 2014

  • Roberts, Kenneth M.; Tormos, José R.; Fitzpatrick, Paul F.
  • Biochemistry, Vol. 53, Issue 16
  • DOI: 10.1021/bi500267c

Identification and Characterization of Two Amino Acids Critical for the Substrate Inhibition of Human Dehydroepiandrosterone Sulfotransferase (SULT2A1)
journal, November 2007

  • Lu, Lu-Yi; Hsieh, Yin-Cheng; Liu, Ming-Yih
  • Molecular Pharmacology, Vol. 73, Issue 3
  • DOI: 10.1124/mol.107.041038

The Sulfuryl Transfer Mechanism: CRYSTAL STRUCTURE OF A VANADATE COMPLEX OF ESTROGEN SULFOTRANSFERASE AND MUTATIONAL ANALYSIS
journal, October 1998

  • Kakuta, Yoshimitsu; Petrotchenko, Evgeny V.; Pedersen, Lars C.
  • Journal of Biological Chemistry, Vol. 273, Issue 42
  • DOI: 10.1074/jbc.273.42.27325

Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493

Genetic and Molecular Basis of Drug Resistance and Species-Specific Drug Action in Schistosome Parasites
journal, November 2013


PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Conserved structural motifs in the sulfotransferase family
journal, April 1998


The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase
journal, October 2006

  • Pica-Mattoccia, Livia; Carlini, Daniele; Guidi, Alessandra
  • Memórias do Instituto Oswaldo Cruz, Vol. 101, Issue suppl 1
  • DOI: 10.1590/S0074-02762006000900048

Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions
journal, November 2004

  • Krissinel, E.; Henrick, K.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12
  • DOI: 10.1107/S0907444904026460

Replacing oxamniquine by praziquantel against Schistosoma mansoni infection in a rural community from the sugar-cane zone of Northeast Brazil: an epidemiological follow-up
journal, September 2001

  • Beck, Lilian; Favre, Tereza Cristina; Pieri, Otávio Sarmento
  • Memórias do Instituto Oswaldo Cruz, Vol. 96, Issue suppl
  • DOI: 10.1590/S0074-02762001000900025

Active Site Mutations and Substrate Inhibition in Human Sulfotransferase 1A1 and 1A3
journal, February 2004

  • Barnett, Amanda C.; Tsvetanov, Sergey; Gamage, Niranjali
  • Journal of Biological Chemistry, Vol. 279, Issue 18
  • DOI: 10.1074/jbc.M312253200

Brazilian studies on the genetics of Schistosoma mansoni
journal, November 2008


Schistosoma mansoni: Hycanthone/oxamniquine resistance is controlled by a single autosomal recessive gene
journal, December 1992


The Protein Data Bank
journal, January 2000


The metabolism of oxamniquine—a new schistosomicide
journal, September 1976


Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine
journal, October 2015

  • Taylor, Alexander B.; Pica-Mattoccia, Livia; Polcaro, Chiara M.
  • PLOS Neglected Tropical Diseases, Vol. 9, Issue 10
  • DOI: 10.1371/journal.pntd.0004132

CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues
journal, July 2006

  • Dundas, J.; Ouyang, Z.; Tseng, J.
  • Nucleic Acids Research, Vol. 34, Issue Web Server
  • DOI: 10.1093/nar/gkl282

Estudo de uma cepa humana de Schistosoma mansoni resistente a agentes esquistossomicidas
journal, December 1973


XDS
journal, January 2010

  • Kabsch, Wolfgang
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2
  • DOI: 10.1107/S0907444909047337

Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: Studies on the formation of catalytically non-productive enzyme complexes
journal, March 2011

  • Gulcan, Hayrettin Ozan; Duffel, Michael W.
  • Archives of Biochemistry and Biophysics, Vol. 507, Issue 2
  • DOI: 10.1016/j.abb.2010.12.027

Computational Evidence for the Catalytic Mechanism of Tyrosylprotein Sulfotransferases: A Density Functional Theory Investigation
journal, July 2015


Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction
journal, March 2013

  • Teramoto, Takamasa; Fujikawa, Yukari; Kawaguchi, Yoshirou
  • Nature Communications, Vol. 4, Issue 1
  • DOI: 10.1038/ncomms2593

Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206