Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Structural analyses reveal the mechanism of inhibition of influenza virus NS1 by two antiviral compounds

Journal Article · · Journal of Biological Chemistry
; ; ; ;

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
NCINIH
OSTI ID:
1481294
Journal Information:
Journal of Biological Chemistry, Vol. 293, Issue 38; ISSN 0021-9258
Publisher:
American Society for Biochemistry and Molecular Biology
Country of Publication:
United States
Language:
ENGLISH

References (60)

A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain March 2011
19F NMR Reveals Multiple Conformations at the Dimer Interface of the Nonstructural Protein 1 Effector Domain from Influenza A Virus April 2014
Emergence of resistance to oseltamivir among influenza A(H1N1) viruses in Europe January 2008
The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway April 2006
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading January 2009
Structure of an avian influenza A virus NS1 protein effector domain August 2008
Influenza Virus NS1 Protein Interacts with the Cellular 30 kDa Subunit of CPSF and Inhibits 3′ End Formation of Cellular Pre-mRNAs June 1998
Expression and characterisation of the influenza A virus non-structural protein NS1 in yeast September 1994
The origin and global emergence of adamantane resistant A/H3N2 influenza viruses June 2009
Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I November 2015
Gradient-Enhanced Triple-Resonance Three-Dimensional NMR Experiments with Improved Sensitivity March 1994
Surveillance for Neuraminidase Inhibitor Resistance among Human Influenza A and B Viruses Circulating Worldwide from 2004 to 2008 July 2008
The influenza virus NS1 protein as a therapeutic target September 2013
Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3′ end processing of cellular pre-mRNAS March 2003
Identification of Adaptive Mutations in the Influenza A Virus Non-Structural 1 Gene That Increase Cytoplasmic Localization and Differentially Regulate Host Gene Expression December 2013
The Virulence of 1997 H5N1 Influenza Viruses in the Mouse Model Is Increased by Correcting a Defect in Their NS1 Proteins May 2011
Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems December 1998
Novel Influenza Virus NS1 Antagonists Block Replication and Restore Innate Immune Function December 2008
Current and future antiviral therapy of severe seasonal and avian influenza April 2008
Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30 January 2013
Inference of Macromolecular Assemblies from Crystalline State September 2007
X-ray structures of NS1 effector domain mutants February 2010
Antiviral resistance due to deletion in the neuraminidase gene and defective interfering-like viral polymerase basic 2 RNA of influenza A virus subtype H3N2 May 2018
The multifunctional NS1 protein of influenza A viruses October 2008
RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates November 2006
Structural basis for suppression of a host antiviral response by influenza A virus August 2008
Using chemical shift perturbation to characterise ligand binding August 2013
The CPSF30 Binding Site on the NS1A Protein of Influenza A Virus Is a Potential Antiviral Target March 2006
Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1 January 2012
Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains November 2017
Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling September 2006
The H5N1 Influenza Virus NS Genes Selected after 1998 Enhance Virus Replication in Mammalian Cells May 2007
X-ray structure of influenza virus NS1 effector domain May 2006
Structure of NS1A effector domain from the influenza A/Udorn/72 virus December 2008
NMR View: A computer program for the visualization and analysis of NMR data September 1994
Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I May 2009
A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine October 2017
Features and development of Coot March 2010
Update: Increase in Human Infections with Novel Asian Lineage Avian Influenza A(H7N9) Viruses During the Fifth Epidemic — China, October 1, 2016–August 7, 2017 September 2017
Epidemiology of Seasonal Influenza: Use of Surveillance Data and Statistical Models to Estimate the Burden of Disease November 2006
PHENIX: a comprehensive Python-based system for macromolecular structure solution January 2010
Inefficient Control of Host Gene Expression by the 2009 Pandemic H1N1 Influenza A Virus NS1 Protein May 2010
Functions of the influenza A virus NS1 protein in antiviral defense June 2015
The annual impact of seasonal influenza in the US: Measuring disease burden and costs June 2007
Generation and Characterization of Recombinant Influenza A (H1N1) Viruses Harboring Amantadine Resistance Mutations January 2005
NMRPipe: A multidimensional spectral processing system based on UNIX pipes November 1995
The Transmissibility and Control of Pandemic Influenza A (H1N1) Virus September 2009
A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence July 2014
An I436N substitution confers resistance of influenza A(H1N1)pdm09 viruses to multiple neuraminidase inhibitors without affecting viral fitness March 2018
Multiple Anti-Interferon Actions of the Influenza A Virus NS1 Protein April 2007
Dimer Interface of the Effector Domain of Non-structural Protein 1 from Influenza A Virus: AN INTERFACE WITH MULTIPLE FUNCTIONS May 2011
Screening of Potent Inhibitor of H1N1 Influenza NS1 CPSF30 Binding Pocket by Molecular Docking January 2012
Conservation of a crystallographic interface suggests a role for β-sheet augmentation in influenza virus NS1 multifunctionality July 2011
Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA May 2006
The 13C Chemical-Shift Index: A simple method for the identification of protein secondary structure using 13C chemical-shift data March 1994
Adamantane Resistance Among Influenza A Viruses Isolated Early During the 2005-2006 Influenza Season in the United States February 2006
Novel inhibitor of influenza non-structural protein 1 blocks multi-cycle replication in an RNase L-dependent manner September 2010
Immunization and treatment updates: 2016-2017 influenza season January 2017
Phaser crystallographic software July 2007
Combined chemical shift changes and amino acid specific chemical shift mapping of protein–protein interactions October 2007

Similar Records

hnRNP A2/B1 interacts with influenza A viral protein NS1 and inhibits virus replication potentially through suppressing NS1 RNA/protein levels and NS1 mRNA nuclear export
Journal Article · 2014 · Virology · OSTI ID:22435007
Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S -Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine
Journal Article · 2016 · Journal of Biological Chemistry · OSTI ID:1347800
+8 more
Structural dynamics reveal subtype-specific activation and inhibition of influenza virus hemagglutinin
Journal Article · 2023 · Journal of Biological Chemistry · OSTI ID:1983522
+4 more

Related Subjects