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Title: Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition

Authors:
ORCiD logo; ; ; ORCiD logo; ; ; ; ; ; ORCiD logo
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
INDUSTRYNIH
OSTI Identifier:
1481293
Resource Type:
Journal Article
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 9; Journal Issue: 1; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

LaRochelle, Jonathan R., Fodor, Michelle, Vemulapalli, Vidyasiri, Mohseni, Morvarid, Wang, Ping, Stams, Travis, LaMarche, Matthew J., Chopra, Rajiv, Acker, Michael G., and Blacklow, Stephen C. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. United States: N. p., 2018. Web. doi:10.1038/s41467-018-06823-9.
LaRochelle, Jonathan R., Fodor, Michelle, Vemulapalli, Vidyasiri, Mohseni, Morvarid, Wang, Ping, Stams, Travis, LaMarche, Matthew J., Chopra, Rajiv, Acker, Michael G., & Blacklow, Stephen C. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. United States. doi:10.1038/s41467-018-06823-9.
LaRochelle, Jonathan R., Fodor, Michelle, Vemulapalli, Vidyasiri, Mohseni, Morvarid, Wang, Ping, Stams, Travis, LaMarche, Matthew J., Chopra, Rajiv, Acker, Michael G., and Blacklow, Stephen C. Tue . "Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition". United States. doi:10.1038/s41467-018-06823-9.
@article{osti_1481293,
title = {Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition},
author = {LaRochelle, Jonathan R. and Fodor, Michelle and Vemulapalli, Vidyasiri and Mohseni, Morvarid and Wang, Ping and Stams, Travis and LaMarche, Matthew J. and Chopra, Rajiv and Acker, Michael G. and Blacklow, Stephen C.},
abstractNote = {},
doi = {10.1038/s41467-018-06823-9},
journal = {Nature Communications},
issn = {2041-1723},
number = 1,
volume = 9,
place = {United States},
year = {2018},
month = {10}
}

Works referenced in this record:

Off-target inhibition by active site-targeting SHP2 inhibitors
journal, August 2018


Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases
journal, December 2016


Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation
journal, July 2011

  • Wang, Wei; Liu, Lijun; Song, Xi
  • Journal of Cellular Biochemistry, Vol. 112, Issue 8
  • DOI: 10.1002/jcb.23125

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs
journal, September 2015


PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment
journal, December 2014


Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
journal, June 2016

  • Chen, Ying-Nan P.; LaMarche, Matthew J.; Chan, Ho Man
  • Nature, Vol. 535, Issue 7610
  • DOI: 10.1038/nature18621

WGE: a CRISPR database for genome engineering: Fig. 1.
journal, May 2015


Drug–target residence time and its implications for lead optimization
journal, August 2006

  • Copeland, Robert A.; Pompliano, David L.; Meek, Thomas D.
  • Nature Reviews Drug Discovery, Vol. 5, Issue 9
  • DOI: 10.1038/nrd2082

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia
journal, April 2003

  • Tartaglia, Marco; Niemeyer, Charlotte M.; Fragale, Alessandra
  • Nature Genetics, Vol. 34, Issue 2
  • DOI: 10.1038/ng1156

Functions of Shp2 in cancer
journal, June 2015

  • Zhang, Jie; Zhang, Fei; Niu, Ruifang
  • Journal of Cellular and Molecular Medicine, Vol. 19, Issue 9
  • DOI: 10.1111/jcmm.12618

Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome
journal, November 2001

  • Tartaglia, Marco; Mehler, Ernest L.; Goldberg, Rosalie
  • Nature Genetics, Vol. 29, Issue 4
  • DOI: 10.1038/ng772

Dual Allosteric Inhibition of SHP2 Phosphatase
journal, January 2018


Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
journal, July 2016

  • Garcia Fortanet, Jorge; Chen, Christine Hiu-Tung; Chen, Ying-Nan P.
  • Journal of Medicinal Chemistry, Vol. 59, Issue 17
  • DOI: 10.1021/acs.jmedchem.6b00680

New developments in the ATSAS program package for small-angle scattering data analysis
journal, March 2012

  • Petoukhov, Maxim V.; Franke, Daniel; Shkumatov, Alexander V.
  • Journal of Applied Crystallography, Vol. 45, Issue 2
  • DOI: 10.1107/S0021889812007662

Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase
journal, July 2014

  • Zeng, Li-Fan; Zhang, Ruo-Yu; Yu, Zhi-Hong
  • Journal of Medicinal Chemistry, Vol. 57, Issue 15
  • DOI: 10.1021/jm5006176

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.
journal, October 1994

  • Noguchi, T.; Matozaki, T.; Horita, K.
  • Molecular and Cellular Biology, Vol. 14, Issue 10
  • DOI: 10.1128/MCB.14.10.6674

Genome engineering using the CRISPR-Cas9 system
journal, October 2013


Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains
journal, February 1995

  • Pluskey, Scott; Wandless, Thomas J.; Walsh, Christopher T.
  • Journal of Biological Chemistry, Vol. 270, Issue 7
  • DOI: 10.1074/jbc.270.7.2897

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations
journal, February 2005


Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2
journal, April 2016


The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
journal, June 2003


Liquid-chromatography-coupled SAXS for accurate sizing of aggregating proteins
journal, June 2004

  • Mathew, Elizabeth; Mirza, Ahmed; Menhart, Nick
  • Journal of Synchrotron Radiation, Vol. 11, Issue 4
  • DOI: 10.1107/S0909049504014086

XDS
journal, January 2010

  • Kabsch, Wolfgang
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2
  • DOI: 10.1107/S0907444909047337

The tyrosine phosphatase Shp2 (PTPN11) in cancer
journal, February 2008

  • Chan, Gordon; Kalaitzidis, Demetrios; Neel, Benjamin G.
  • Cancer and Metastasis Reviews, Vol. 27, Issue 2
  • DOI: 10.1007/s10555-008-9126-y

Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206

Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER
journal, March 2012

  • Smart, Oliver S.; Womack, Thomas O.; Flensburg, Claus
  • Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4
  • DOI: 10.1107/S0907444911056058

Crystal Structure of the Tyrosine Phosphatase SHP-2
journal, February 1998