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Title: Sex-Dependent Effects of the Histone Deacetylase Inhibitor, Sodium Valproate, on Reversal Learning After Developmental Arsenic Exposure

Abstract

Here, several studies have demonstrated that exposure to arsenic in drinking water adversely affects brain development and cognitive function in adulthood. While the mechanism by which arsenic induces adverse neurological outcomes remains elusive, studies suggest a link between reduced levels of histone acetylation and impaired performance on a variety of behavioral tasks following arsenic exposure.

Authors:
ORCiD logo [1];  [2];  [2];  [2];  [2];  [2]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  2. Univ. of New Mexico Health Sciences Center, Albuquerque, NM (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
National Institutes of Health (NIH); USDOE
OSTI Identifier:
1481146
Report Number(s):
LA-UR-18-20125
Journal ID: ISSN 1664-8021
Grant/Contract Number:  
AC52-06NA25396
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Frontiers in Genetics
Additional Journal Information:
Journal Volume: 9; Journal ID: ISSN 1664-8021
Publisher:
Frontiers
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Biological Science; histone deacetylase inhibitors; prenatal arsenic; reversal learning; BDNF; valproate; cognitive flexibility

Citation Formats

Tyler, Christina R. Steadman, Smoake, Jane J. W., Solomon, Elizabeth R., Villicana, Estrella, Caldwell, Kevin K., and Allan, Andrea M. Sex-Dependent Effects of the Histone Deacetylase Inhibitor, Sodium Valproate, on Reversal Learning After Developmental Arsenic Exposure. United States: N. p., 2018. Web. doi:10.3389/fgene.2018.00200.
Tyler, Christina R. Steadman, Smoake, Jane J. W., Solomon, Elizabeth R., Villicana, Estrella, Caldwell, Kevin K., & Allan, Andrea M. Sex-Dependent Effects of the Histone Deacetylase Inhibitor, Sodium Valproate, on Reversal Learning After Developmental Arsenic Exposure. United States. doi:10.3389/fgene.2018.00200.
Tyler, Christina R. Steadman, Smoake, Jane J. W., Solomon, Elizabeth R., Villicana, Estrella, Caldwell, Kevin K., and Allan, Andrea M. Fri . "Sex-Dependent Effects of the Histone Deacetylase Inhibitor, Sodium Valproate, on Reversal Learning After Developmental Arsenic Exposure". United States. doi:10.3389/fgene.2018.00200. https://www.osti.gov/servlets/purl/1481146.
@article{osti_1481146,
title = {Sex-Dependent Effects of the Histone Deacetylase Inhibitor, Sodium Valproate, on Reversal Learning After Developmental Arsenic Exposure},
author = {Tyler, Christina R. Steadman and Smoake, Jane J. W. and Solomon, Elizabeth R. and Villicana, Estrella and Caldwell, Kevin K. and Allan, Andrea M.},
abstractNote = {Here, several studies have demonstrated that exposure to arsenic in drinking water adversely affects brain development and cognitive function in adulthood. While the mechanism by which arsenic induces adverse neurological outcomes remains elusive, studies suggest a link between reduced levels of histone acetylation and impaired performance on a variety of behavioral tasks following arsenic exposure.},
doi = {10.3389/fgene.2018.00200},
journal = {Frontiers in Genetics},
issn = {1664-8021},
number = ,
volume = 9,
place = {United States},
year = {2018},
month = {6}
}

Journal Article:
Free Publicly Available Full Text
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