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Title: Terahertz biosensing with a graphene-metamaterial heterostructure platform

Abstract

Terahertz (THz) radiation attracted great interest in the fields of material characterization, nondestructive security screening, clinical diagnostics, and identification of chemicals and molecules. Label-free THz sensing of trace amount of targets including biomolecules is promising because of their rich spectral fingerprint in this electromagnetic region; however, improving the sensitivity remains to be a challenge, partially due to the limitations of THz sources and detectors. The resonantly enhanced electromagnetic fields in metamaterials and metasurfaces offer a potentially viable solution, although highly complicated decoration process is still needed for biosensing on the surface of metamaterials. Here we demonstrate a simple biosensing platform by integrating a monolayer graphene on a THz metamaterial absorber cavity, where the introduction of sensing targets results in a large change of the metamaterial resonant absorption (or reflection) because of their strong interaction with graphene. We experimentally show its ultrahigh sensitivity through detecting trace amount of chlorpyrifos methyl down to 0.2 ng. Furthermore, using simple decoration steps and utilizing DNA to capture thrombin, we further show the feasibility of this platform serving as a sensitive biosensor.

Authors:
 [1];  [1];  [1];  [1];  [2];  [1];  [1]; ORCiD logo [3];  [4]
  1. Zhejiang Univ., Hangzhou (People's Republic of China)
  2. Nanyang Technological Univ. (Singapore)
  3. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  4. Zhejiang Univ., Hangzhou (People's Republic of China); Zhejiang A & F Univ., Zhejiang (China)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE Laboratory Directed Research and Development (LDRD) Program
OSTI Identifier:
1480035
Report Number(s):
LA-UR-18-29562
Journal ID: ISSN 0008-6223
Grant/Contract Number:  
AC52-06NA25396
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Carbon
Additional Journal Information:
Journal Volume: 141; Journal Issue: C; Journal ID: ISSN 0008-6223
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Xu, Wendao, Xie, Lijuan, Zhu, Jianfei, Tang, Longhua, Singh, Ranjan, Wang, Chen, Ma, Yungui, Chen, Hou -Tong, and Ying, Yibin. Terahertz biosensing with a graphene-metamaterial heterostructure platform. United States: N. p., 2018. Web. doi:10.1016/j.carbon.2018.09.050.
Xu, Wendao, Xie, Lijuan, Zhu, Jianfei, Tang, Longhua, Singh, Ranjan, Wang, Chen, Ma, Yungui, Chen, Hou -Tong, & Ying, Yibin. Terahertz biosensing with a graphene-metamaterial heterostructure platform. United States. https://doi.org/10.1016/j.carbon.2018.09.050
Xu, Wendao, Xie, Lijuan, Zhu, Jianfei, Tang, Longhua, Singh, Ranjan, Wang, Chen, Ma, Yungui, Chen, Hou -Tong, and Ying, Yibin. 2018. "Terahertz biosensing with a graphene-metamaterial heterostructure platform". United States. https://doi.org/10.1016/j.carbon.2018.09.050. https://www.osti.gov/servlets/purl/1480035.
@article{osti_1480035,
title = {Terahertz biosensing with a graphene-metamaterial heterostructure platform},
author = {Xu, Wendao and Xie, Lijuan and Zhu, Jianfei and Tang, Longhua and Singh, Ranjan and Wang, Chen and Ma, Yungui and Chen, Hou -Tong and Ying, Yibin},
abstractNote = {Terahertz (THz) radiation attracted great interest in the fields of material characterization, nondestructive security screening, clinical diagnostics, and identification of chemicals and molecules. Label-free THz sensing of trace amount of targets including biomolecules is promising because of their rich spectral fingerprint in this electromagnetic region; however, improving the sensitivity remains to be a challenge, partially due to the limitations of THz sources and detectors. The resonantly enhanced electromagnetic fields in metamaterials and metasurfaces offer a potentially viable solution, although highly complicated decoration process is still needed for biosensing on the surface of metamaterials. Here we demonstrate a simple biosensing platform by integrating a monolayer graphene on a THz metamaterial absorber cavity, where the introduction of sensing targets results in a large change of the metamaterial resonant absorption (or reflection) because of their strong interaction with graphene. We experimentally show its ultrahigh sensitivity through detecting trace amount of chlorpyrifos methyl down to 0.2 ng. Furthermore, using simple decoration steps and utilizing DNA to capture thrombin, we further show the feasibility of this platform serving as a sensitive biosensor.},
doi = {10.1016/j.carbon.2018.09.050},
url = {https://www.osti.gov/biblio/1480035}, journal = {Carbon},
issn = {0008-6223},
number = C,
volume = 141,
place = {United States},
year = {Mon Sep 17 00:00:00 EDT 2018},
month = {Mon Sep 17 00:00:00 EDT 2018}
}

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Cited by: 110 works
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Works referenced in this record:

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Works referencing / citing this record:

Terahertz Biochemical Molecule‐Specific Sensors
journal, July 2019


Labyrinth Metasurface for Biosensing Applications: Numerical Study on the New Paradigm of Metageometries
journal, October 2019


Terahertz Sensing Based on Metasurfaces
journal, July 2019


Terahertz biosensing based on bi-layer metamaterial absorbers toward ultra-high sensitivity and simple fabrication
journal, September 2019


Highly sensitive terahertz fingerprint sensing with high-Q guided resonance in photonic crystal cavity
journal, January 2019