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Title: High throughput near infrared screening discovers DNA-templated silver clusters with peak fluorescence beyond 950 nm

Abstract

In this study, we use high throughput near-infrared (NIR) screening technology to discover abundant new DNA-stabilized silver clusters, Ag N-DNA, that fluoresce in the NIR. These include the longest wavelength Ag N-DNA fluorophores identified to date, with peak emission beyond 950 nm that extends into the NIR II tissue transparency window, and the highest silver content.

Authors:
 [1]; ORCiD logo [2];  [1];  [3]; ORCiD logo [3]; ORCiD logo [1]
  1. Univ. of California, Santa Barbara, CA (United States)
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  3. University at Albany, SUNY, Albany, NY (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC); USDOE Laboratory Directed Research and Development (LDRD) Program
OSTI Identifier:
1479965
Alternate Identifier(s):
OSTI ID: 1479893
Report Number(s):
LA-UR-18-29958; LA-UR-18-28178
Journal ID: ISSN 2040-3364; NANOHL
Grant/Contract Number:  
AC52-06NA25396; 89233218CNA000001
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Nanoscale
Additional Journal Information:
Journal Volume: 10; Journal Issue: 42; Journal ID: ISSN 2040-3364
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 36 MATERIALS SCIENCE; Material Science

Citation Formats

Swasey, Steven M., Copp, Stacy Maria, Nicholson, Hunter C., Gorovits, Alexander, Bogdanov, Petko, and Gwinn, Elisabeth G. High throughput near infrared screening discovers DNA-templated silver clusters with peak fluorescence beyond 950 nm. United States: N. p., 2018. Web. doi:10.1039/C8NR05781H.
Swasey, Steven M., Copp, Stacy Maria, Nicholson, Hunter C., Gorovits, Alexander, Bogdanov, Petko, & Gwinn, Elisabeth G. High throughput near infrared screening discovers DNA-templated silver clusters with peak fluorescence beyond 950 nm. United States. doi:10.1039/C8NR05781H.
Swasey, Steven M., Copp, Stacy Maria, Nicholson, Hunter C., Gorovits, Alexander, Bogdanov, Petko, and Gwinn, Elisabeth G. Wed . "High throughput near infrared screening discovers DNA-templated silver clusters with peak fluorescence beyond 950 nm". United States. doi:10.1039/C8NR05781H. https://www.osti.gov/servlets/purl/1479965.
@article{osti_1479965,
title = {High throughput near infrared screening discovers DNA-templated silver clusters with peak fluorescence beyond 950 nm},
author = {Swasey, Steven M. and Copp, Stacy Maria and Nicholson, Hunter C. and Gorovits, Alexander and Bogdanov, Petko and Gwinn, Elisabeth G.},
abstractNote = {In this study, we use high throughput near-infrared (NIR) screening technology to discover abundant new DNA-stabilized silver clusters, AgN-DNA, that fluoresce in the NIR. These include the longest wavelength AgN-DNA fluorophores identified to date, with peak emission beyond 950 nm that extends into the NIR II tissue transparency window, and the highest silver content.},
doi = {10.1039/C8NR05781H},
journal = {Nanoscale},
issn = {2040-3364},
number = 42,
volume = 10,
place = {United States},
year = {2018},
month = {10}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

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Cited by: 3 works
Citation information provided by
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Figures / Tables:

Fig. 1 Fig. 1: NIR emission from AgN-DNA formed in three separate 384-well microplates containing a total of 844 unique DNA strands. Wells for which <λ> exceeds 750 nm are marked by squares with sizes that indicate integrated spectral intensity (Color bar for <λ> is at the lower right). Axes denote themore » well location of each template by row letter and column number. UV excitation (280-320nm). Plates A, B and C contained 375, 374 and 95 DNA templates, respectively.« less

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Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.