skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Weight change since age 20 and incident risk of obesity‐related cancer in Japan: a pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study

Journal Article · · International Journal of Cancer
DOI:https://doi.org/10.1002/ijc.31743· OSTI ID:1479828
ORCiD logo [1]; ORCiD logo [1];  [1];  [1];  [1];  [1]
  1. Division of Epidemiology, Department of Health Informatics and Public Health Tohoku University School of Public Health, Graduate School of Medicine Sendai Japan
+ Show Author Affiliations

It is unclear whether weight change during adulthood affects the risk of obesity‐related cancers such as those of the esophagus, colorectum, pancreas, breast, endometrium, and kidney among Japanese, where obesity is less frequent and less severe. We examined the association between weight change during adulthood and the risk of obesity‐related cancer among Japanese by conducting a pooled analysis of two prospective studies of residents in Miyagi Prefecture, Japan. A total of 78,743 persons (40,422 women and 38,321 men) aged 40–79 years participated in the Miyagi Cohort Study in 1990 and in the Ohsaki Cohort Study in 1994. Weight change since age 20 was divided into four categories (weight loss; stable weight; moderate weight gain; high weight gain). Cox proportional hazards regression analysis was used to estimate the multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) for obesity‐related cancer incidence. During 1,057,899 person‐years of follow up, 4,467 cases of obesity‐related cancer (women; 1,916 cases, men; 2,551cases) were identified. In women, compared to the stable weight, weight gain was associated with an increased risk of obesity‐related cancer (moderate weight gain; HRs = 1.10, 95%CIs: 0.97–1.26, high weight gain; HRs = 1.29, 95%CIs: 1.14–1.47). The results indicate that weight gain since age 20 was associated with a significantly increased risk of obesity‐related cancer among Japanese women. By contrast, in men, our study found that weight change is not associated with the incidence of obesity‐related cancer.

Sponsoring Organization:
USDOE
OSTI ID:
1479828
Alternate ID(s):
OSTI ID: 1479829
Journal Information:
International Journal of Cancer, Journal Name: International Journal of Cancer Vol. 144 Journal Issue: 5; ISSN 0020-7136
Publisher:
Wiley Blackwell (John Wiley & Sons)Copyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 12 works
Citation information provided by
Web of Science

References (27)

Obesity and Cancer: The Role of Dysfunctional Adipose Tissue journal September 2009
Adiposity and cancer at major anatomical sites: umbrella review of the literature journal February 2017
Prospective study of body size throughout the life-course and the incidence of endometrial cancer among premenopausal and postmenopausal women: Body size and endometrial cancer incidence journal February 2015
Overweight in Early Adulthood, Adult Weight Change, and Risk of Type 2 Diabetes, Cardiovascular Diseases, and Certain Cancers in Men: a Cohort Study journal April 2014
Obesity as a Major Risk Factor for Cancer journal January 2013
Body weight at age 20 years, subsequent weight change and breast cancer risk defined by estrogen and progesterone receptor status-the Japan public health center-based prospective study journal April 2011
Weight change later in life and colon and rectal cancer risk in participants in the EPIC-PANACEA study journal November 2013
Alcohol Drinking and Esophageal Cancer Risk: An Evaluation Based on a Systematic Review of Epidemiologic Evidence Among the Japanese Population journal March 2011
The association between coffee consumption and bladder cancer incidence in a pooled analysis of the Miyagi Cohort Study and Ohsaki Cohort Study journal January 2017
Body weight gain and risk of colorectal cancer: a systematic review and meta-analysis of observational studies: Weight gain and colorectal cancer journal April 2015
A Prospective Cohort Study on National Health Insurance Beneficiaries in Ohsaki, Miyagi Prefecture, Japan: Study Design, Profiles of the Subjects and Medical Cost During the First Year journal January 1998
Postmenopausal Hormone Replacement Therapy: Scientific Review journal August 2002
Weight Gain and Alcohol Drinking Associations with Breast Cancer Risk in Japanese Postmenopausal Women - Results from the Japan Collaborative Cohort (JACC) Study journal April 2016
Association between adult weight gain and colorectal cancer: A dose-response meta-analysis of observational studies: Adult weight gain and colorectal cancer journal November 2014
Obesity/Weight Gain and Breast Cancer Risk: Findings From the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk journal January 2013
Obesity and Cancer Risk: Recent Review and Evidence journal November 2010
Prospective cohort study of general and central obesity, weight change trajectory and risk of major cancers among Chinese women: Cohort study of obesity and cancer risk journal May 2016
Medical care expenditure associated with body mass index in Japan: the Ohsaki Study journal July 2002
Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition journal November 2013
Adulthood Weight Change and Risk of Colorectal Cancer in the Nurses' Health Study and Health Professionals Follow-up Study journal April 2015
Body-mass index and cancer mortality in the Asia-Pacific Cohort Studies Collaboration: pooled analyses of 424 519 participants journal August 2010
Body Fatness and Cancer — Viewpoint of the IARC Working Group journal August 2016
A Cohort Study on the Relation of Lifestyle, Personality and Biologic Markers to Cancer in Miyagi, Japan : Study Design, Response Rate and Profiles of the Cohort Subjects journal January 1995
Associations of Weight Gain From Early to Middle Adulthood With Major Health Outcomes Later in Life journal July 2017
Estrogen plus Progestin and Colorectal Cancer in Postmenopausal Women journal March 2004
Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States: Potentially Preventable Cancers in US journal November 2017
Adult Weight Gain and Adiposity-Related Cancers: A Dose-Response Meta-Analysis of Prospective Observational Studies journal January 2015

Similar Records

Second Malignant Neoplasms in Digestive Organs After Childhood Cancer: A Cohort-Nested Case-Control Study
Journal Article · Thu Mar 01 00:00:00 EST 2012 · International Journal of Radiation Oncology, Biology and Physics · OSTI ID:1479828
+12 more
Lifetime risk of suicide among survivors of the atomic bombings of Japan
Journal Article · Fri Jan 01 00:00:00 EST 2021 · Epidemiology and Psychiatric Sciences · OSTI ID:1479828
+2 more
Residential radon exposure and risk of incident hematologic malignancies in the Cancer Prevention Study-II Nutrition Cohort
Journal Article · Fri Jul 15 00:00:00 EDT 2016 · Environmental Research · OSTI ID:1479828
+3 more

Related Subjects