3D‐Printed Carbon Electrodes for Neurotransmitter Detection

Yang, Cheng; Cao, Qun; Puthongkham, Pumidech; Lee, Scott T.; Ganesana, Mallikarjunarao; Lavrik, Nickolay V.; Venton, B. Jill

doi:10.1002/ange.201809992

Title: 3D‐Printed Carbon Electrodes for Neurotransmitter Detection

Journal Article · Thu Oct 04 00:00:00 EDT 2018 · Angewandte Chemie

DOI:https://doi.org/10.1002/ange.201809992· OSTI ID:1476653

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^[1]; Lee, Scott T. ^[1];

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Dept. of Chemistry University of Virginia Charlottesville VA 22901 USA
Center for Nanophase Material Science Oak Ridge National Lab Oak Ridge TN 37831 USA

Abstract Implantable neural microsensors have significantly advanced neuroscience research, but the geometry of most probes is limited by the fabrication methods. Therefore, new methods are needed for batch‐manufacturing with high reproducibility. Herein, a novel method is developed using two‐photon nanolithography followed by pyrolysis for fabrication of free‐standing microelectrodes with a carbon electroactive surface. 3D‐printed spherical and conical electrodes were characterized with slow scan cyclic voltammetry (CV). With fast‐scan CV, the electrodes showed low dopamine LODs of 11±1 n m (sphere) and 10±2 n m (cone), high sensitivity to multiple neurochemicals, and high reproducibility. Spherical microelectrodes were used to detect dopamine in a brain slice and in vivo, demonstrating they are robust enough for tissue implantation. This work is the first demonstration of 3D‐printing of free‐standing carbon electrodes; and the method is promising for batch fabrication of customized, implantable neural sensors.

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Sponsoring Organization:: USDOE

OSTI ID:: 1476653

Journal Information:: Angewandte Chemie, Journal Name: Angewandte Chemie Vol. 130 Journal Issue: 43; ISSN 0044-8249

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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