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Title: Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

Authors:
 [1];  [2];  [2];  [2];  [2];  [2];  [2];  [2];  [2];  [2];  [2];  [2];  [2]; ORCiD logo [1]
  1. Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA
  2. Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
UNIVERSITYINDUSTRYNIH
OSTI Identifier:
1476080
Resource Type:
Journal Article
Journal Name:
Nucleic Acids Research
Additional Journal Information:
Journal Volume: 46; Journal Issue: 16; Journal ID: ISSN 0305-1048
Publisher:
Oxford University Press
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Harp, Joel M., Guenther, Dale C., Bisbe, Anna, Perkins, Lydia, Matsuda, Shigeo, Bommineni, Gopal R., Zlatev, Ivan, Foster, Donald J., Taneja, Nate, Charisse, Klaus, Maier, Martin A., Rajeev, Kallanthottathil G., Manoharan, Muthiah, and Egli, Martin. Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity. United States: N. p., 2018. Web. doi:10.1093/nar/gky703.
Harp, Joel M., Guenther, Dale C., Bisbe, Anna, Perkins, Lydia, Matsuda, Shigeo, Bommineni, Gopal R., Zlatev, Ivan, Foster, Donald J., Taneja, Nate, Charisse, Klaus, Maier, Martin A., Rajeev, Kallanthottathil G., Manoharan, Muthiah, & Egli, Martin. Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity. United States. doi:10.1093/nar/gky703.
Harp, Joel M., Guenther, Dale C., Bisbe, Anna, Perkins, Lydia, Matsuda, Shigeo, Bommineni, Gopal R., Zlatev, Ivan, Foster, Donald J., Taneja, Nate, Charisse, Klaus, Maier, Martin A., Rajeev, Kallanthottathil G., Manoharan, Muthiah, and Egli, Martin. Sat . "Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity". United States. doi:10.1093/nar/gky703.
@article{osti_1476080,
title = {Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity},
author = {Harp, Joel M. and Guenther, Dale C. and Bisbe, Anna and Perkins, Lydia and Matsuda, Shigeo and Bommineni, Gopal R. and Zlatev, Ivan and Foster, Donald J. and Taneja, Nate and Charisse, Klaus and Maier, Martin A. and Rajeev, Kallanthottathil G. and Manoharan, Muthiah and Egli, Martin},
abstractNote = {},
doi = {10.1093/nar/gky703},
journal = {Nucleic Acids Research},
issn = {0305-1048},
number = 16,
volume = 46,
place = {United States},
year = {2018},
month = {8}
}