Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

Journal Article · Sat Aug 11 00:00:00 EDT 2018 · Nucleic Acids Research

DOI:https://doi.org/10.1093/nar/gky703· OSTI ID:1476080

Harp, Joel M. ^[1]; Guenther, Dale C. ^[2]; Bisbe, Anna ^[2]; Perkins, Lydia ^[2]; Matsuda, Shigeo ^[2]; Bommineni, Gopal R. ^[2]; Zlatev, Ivan ^[2]; Foster, Donald J. ^[2]; Taneja, Nate ^[2]; Charisse, Klaus ^[2]; Maier, Martin A. ^[2]; Rajeev, Kallanthottathil G. ^[2]; Manoharan, Muthiah ^[2]; Egli, Martin  ^[1]

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1. Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA
2. Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
• Sponsoring Organization: UNIVERSITYINDUSTRYNIH
• OSTI ID: 1476080
• Journal Information: Nucleic Acids Research, Vol. 46, Issue 16; ISSN 0305-1048
• Publisher: Oxford University Press
• Country of Publication: United States
• Language: ENGLISH