Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug

Chen, X. Chelsea; Oh, Hee Jeung; Yu, Jay F.; Yang, Jeffrey K.; Petzetakis, Nikos; Patel, Anand S.; Hetts, Steven W.; Balsara, Nitash P.

doi:10.1021/acsmacrolett.6b00459

Title: Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug

Journal Article · Sat Jul 23 00:00:00 EDT 2016 · ACS Macro Letters

DOI:https://doi.org/10.1021/acsmacrolett.6b00459· OSTI ID:1271469

Chen, X. Chelsea ^[1]; Oh, Hee Jeung ^[1]; Yu, Jay F. ^[2]; Yang, Jeffrey K. ^[2]; Petzetakis, Nikos ^[1]; Patel, Anand S. ^[2]; Hetts, Steven W. ^[2]; Balsara, Nitash P. ^[1]

Department of Chemical and Biomolecular Engineering, University of California−Berkeley, Berkeley, California 94720, United States
Department of Radiology and Biomedical Imaging, University of California−San Francisco, San Francisco, California 94107, United States

We introduce the use of block copolymer membranes for an emerging application, "drug capture". The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment.

View Journal Article

Cite

Export

Save

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); University of California, Berkeley, CA (United States); Univ. of California, San Francisco, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); National Inst. of Health (NIH) (United States)

Grant/Contract Number:: AC02-05CH11231; 1R01CA194533; 1R41CA183327

OSTI ID:: 1271469

Alternate ID(s):: OSTI ID: 1314044; OSTI ID: 1373378; OSTI ID: 1474958

Report Number(s):: LBNL-1005980

Journal Information:: ACS Macro Letters, Journal Name: ACS Macro Letters Vol. 5 Journal Issue: 8; ISSN 2161-1653

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 16 works

Citation information provided by
Web of Science

References (29)

Sulfonated hydrocarbon membranes for medium-temperature and low-humidity proton exchange membrane fuel cells (PEMFCs) Park, Chi Hoon; Lee, Chang Hyun; Guiver, Michael D. Progress in Polymer Science, Vol. 36, Issue 11 https://doi.org/10.1016/j.progpolymsci.2011.06.001	journal	November 2011
A review of reverse osmosis membrane materials for desalination—Development to date and future potential Lee, Kah Peng; Arnot, Tom C.; Mattia, Davide Journal of Membrane Science, Vol. 370, Issue 1-2 https://doi.org/10.1016/j.memsci.2010.12.036	journal	March 2011
Adsorption of drugs onto a poly(acrylic acid) grafted cation-exchange membrane Åkerman, Satu; Åkerman, Kari; Karppi, Jouni European Journal of Pharmaceutical Sciences, Vol. 9, Issue 2 https://doi.org/10.1016/S0928-0987(99)00055-X	journal	December 1999
Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications Shi, Jinjun; Votruba, Alexander R.; Farokhzad, Omid C. Nano Letters, Vol. 10, Issue 9 https://doi.org/10.1021/nl102184c	journal	September 2010
Dendrimers and dendritic polymers in drug delivery Gillies, E.; Frechet, J. Drug Discovery Today, Vol. 10, Issue 1 https://doi.org/10.1016/S1359-6446(04)03276-3	journal	January 2005
Morphology–Conductivity Relationship of Single-Ion-Conducting Block Copolymer Electrolytes for Lithium Batteries Inceoglu, Sebnem; Rojas, Adriana A.; Devaux, Didier ACS Macro Letters, Vol. 3, Issue 6 https://doi.org/10.1021/mz5001948	journal	May 2014
Ion-exchange resins: carrying drug delivery forward Anand, Vikas; Kandarapu, Raghupathi; Garg, Sanjay Drug Discovery Today, Vol. 6, Issue 17 https://doi.org/10.1016/S1359-6446(01)01922-5	journal	September 2001
Water permeability and water/salt selectivity tradeoff in polymers for desalination Geise, Geoffrey M.; Park, Ho Bum; Sagle, Alyson C. Journal of Membrane Science, Vol. 369, Issue 1-2 https://doi.org/10.1016/j.memsci.2010.11.054	journal	March 2011
Biodegradable block copolymers as injectable drug-delivery systems Jeong, Byeongmoon; Bae, You Han; Lee, Doo Sung Nature, Vol. 388, Issue 6645 https://doi.org/10.1038/42218	journal	August 1997
Anion exchange membranes: Current status and moving forward Hickner, Michael A.; Herring, Andrew M.; Coughlin, E. Bryan Journal of Polymer Science Part B: Polymer Physics, Vol. 51, Issue 24, p. 1727-1735 https://doi.org/10.1002/polb.23395	journal	October 2013
Compliant glass–polymer hybrid single ion-conducting electrolytes for lithium batteries Villaluenga, Irune; Wujcik, Kevin H.; Tong, Wei Proceedings of the National Academy of Sciences, Vol. 113, Issue 1 https://doi.org/10.1073/pnas.1520394112	journal	December 2015
Water Uptake and Proton Conductivity in Porous Block Copolymer Electrolyte Membranes Chen, X. Chelsea; Kortright, Jeffrey B.; Balsara, Nitash P. Macromolecules, Vol. 48, Issue 16 https://doi.org/10.1021/acs.macromol.5b00950	journal	August 2015
Development and Validation of Endovascular Chemotherapy Filter Device for Removing High-Dose Doxorubicin: Preclinical Study Patel, Anand S.; Saeed, Maythem; Yee, Erin J. Journal of Medical Devices, Vol. 8, Issue 4 https://doi.org/10.1115/1.4027444	journal	August 2014
Trans-catheter arterial chemoembolization as first-line treatment for hepatic metastases from endocrine tumors Roche, Alain; Girish, Baragur V.; de Baère, Thierry European Radiology, Vol. 13, Issue 1 https://doi.org/10.1007/s00330-002-1558-0	journal	January 2003
Risk Factors for Doxorubicin-lnduced Congestive Heart Failure Von Hoff, Daniel D. Annals of Internal Medicine, Vol. 91, Issue 5 https://doi.org/10.7326/0003-4819-91-5-710	journal	November 1979
A novel approach for preparation of pH-sensitive hydrogels for enteric drug delivery Dong, Liang-chang; Hoffman, Allan S. Journal of Controlled Release, Vol. 15, Issue 2 https://doi.org/10.1016/0168-3659(91)90072-L	journal	April 1991
Boronated starburst dendrimer-monoclonal antibody immunoconjugates: Evaluation as a potential delivery system for neutron capture therapy Barth, Rolf F.; Adams, Dianne M.; Soloway, Albert H. Bioconjugate Chemistry, Vol. 5, Issue 1 https://doi.org/10.1021/bc00025a008	journal	January 1994
Enhanced angiogenesis through controlled release of basic fibroblast growth factor from peptide amphiphile for tissue regeneration Hosseinkhani, Hossein; Hosseinkhani, Mohsen; Khademhosseini, Ali Biomaterials, Vol. 27, Issue 34 https://doi.org/10.1016/j.biomaterials.2006.08.003	journal	December 2006
Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems Nasongkla, Norased; Bey, Erik; Ren, Jimin Nano Letters, Vol. 6, Issue 11 https://doi.org/10.1021/nl061412u	journal	November 2006
Highly Chlorine-Tolerant Polymers for Desalination Park, Ho Bum; Freeman, Benny D.; Zhang, Zhong-Bio Angewandte Chemie International Edition, Vol. 47, Issue 32 https://doi.org/10.1002/anie.200800454	journal	July 2008
Single-ion BAB triblock copolymers as highly efficient electrolytes for lithium-metal batteries Bouchet, Renaud; Maria, Sébastien; Meziane, Rachid Nature Materials, Vol. 12, Issue 5 https://doi.org/10.1038/nmat3602	journal	March 2013
Design of Environment-Sensitive Supramolecular Assemblies for Intracellular Drug Delivery: Polymeric Micelles that are Responsive to Intracellular pH Change Bae, Younsoo; Fukushima, Shigeto; Harada, Atsushi Angewandte Chemie International Edition, Vol. 42, Issue 38 https://doi.org/10.1002/anie.200250653	journal	October 2003
Effect of Morphology of Nanoscale Hydrated Channels on Proton Conductivity in Block Copolymer Electrolyte Membranes Chen, X. Chelsea; Wong, David T.; Yakovlev, Sergey Nano Letters, Vol. 14, Issue 7 https://doi.org/10.1021/nl501537p	journal	June 2014
Block Copolymers for Fuel Cells Elabd, Yossef A.; Hickner, Michael A. Macromolecules, Vol. 44, Issue 1 https://doi.org/10.1021/ma101247c	journal	January 2011
Evaluation of Doxorubicin-Loaded 3-Helix Micelles as Nanocarriers Dube, Nikhil; Shu, Jessica Y.; Dong, He Biomacromolecules, Vol. 14, Issue 10 https://doi.org/10.1021/bm4010518	journal	September 2013
A Magnetically Triggered Composite Membrane for On-Demand Drug Delivery Hoare, Todd; Santamaria, Jesus; Goya, Gerardo F. Nano Letters, Vol. 9, Issue 10 https://doi.org/10.1021/nl9018935	journal	October 2009
Nonresectable Hepatocellular Carcinoma: Long-term Toxicity in Patients Treated with Transarterial Chemoembolization—Single-Center Experience Buijs, Manon; Vossen, Josephina A.; Frangakis, Constantine Radiology, Vol. 249, Issue 1 https://doi.org/10.1148/radiol.2483071902	journal	October 2008
Review on transarterial chemoembolization in hepatocellular carcinoma: Palliative, combined, neoadjuvant, bridging, and symptomatic indications Vogl, Thomas J.; Naguib, Nagy N. N.; Nour-Eldin, Nour-Eldin A. European Journal of Radiology, Vol. 72, Issue 3 https://doi.org/10.1016/j.ejrad.2008.08.007	journal	December 2009
Biodegradable polymeric nanoparticles as drug delivery devices Soppimath, Kumaresh S.; Aminabhavi, Tejraj M.; Kulkarni, Anandrao R. Journal of Controlled Release, Vol. 70, Issue 1-2 https://doi.org/10.1016/S0168-3659(00)00339-4	journal	January 2001

Similar Records

Swelling of individual nanodomains in hydrated block copolymer electrolyte membranes

Journal Article · Fri Jul 20 00:00:00 EDT 2018 · Journal of Chemical Physics · OSTI ID:1271469

Chen, X. Chelsea; Jiang, Xi; Balsara, Nitash P.

3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body

Journal Article · Wed Jan 09 00:00:00 EST 2019 · ACS Central Science · OSTI ID:1271469

Oh, Hee Jeung; Aboian, Mariam S.; Yi, Michael Y. J.; +12 more

Controlled release of cortisone drugs from block copolymers synthetized by ATRP

Journal Article · Wed May 18 00:00:00 EDT 2016 · AIP Conference Proceedings · OSTI ID:1271469

Valenti, G.; La Carta, S.; Rapisarda, M.; +6 more

Related Subjects

36 MATERIALS SCIENCE
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Title: Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug

Citation Formats

References (29)

Similar Records

Related Subjects