Upconverting nanoparticle micro-lightbulbs designed for deep tissue optical stimulation and imaging

Chamanzar, Maysamreza; Garfield, David J.; Iafrati, Jillian; Chan, Emory M.; Sohal, Vikaas; Cohen, Bruce E.; Schuck, P. James; Maharbiz, Michel M.

doi:10.1364/BOE.9.004359

Title: Upconverting nanoparticle micro-lightbulbs designed for deep tissue optical stimulation and imaging

Journal Article · Mon Aug 20 00:00:00 EDT 2018 · Biomedical Optics Express

DOI:https://doi.org/10.1364/BOE.9.004359· OSTI ID:1465251

Chamanzar, Maysamreza; Garfield, David J.; Iafrati, Jillian; Chan, Emory M.; Sohal, Vikaas; Cohen, Bruce E.; Schuck, P. James; Maharbiz, Michel M.

Optical methods for imaging and stimulation of biological events based on the use of visible light are limited to the superficial layers of tissue due to the significant absorption and scattering of light. Here, we demonstrate the design and implementation of passive micro-structured lightbulbs (MLBs) containing bright-emitting lanthanide-doped upconverting nanoparticles (UCNPs) for light delivery deep into the tissue. The MLBs are realized as cylindrical pillars made of Parylene C polymer that can be implanted deep into the tissue. The encapsulated UCNPs absorb near-infrared (NIR) light at λ = 980 nm, which undergoes much less absorption than the blue light in the brain tissue, and then locally emit blue light (¹G4→³H₆ and ¹D₂→³F₄ transitions) that can be used for optogenetic excitation of neurons in the brain. The ³H₄→³H₆ transition will result in the emission of higher energy NIR photons at λ = 800 nm that can be used for imaging and tracking MLBs through thick tissue.

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Research Organization:: National Renewable Energy Laboratory (NREL), Golden, CO (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); Ministry of Science and ICT, South Korea

Grant/Contract Number:: AC02-05CH11231; AC36-08GO28308

OSTI ID:: 1465251

Alternate ID(s):: OSTI ID: 1474841; OSTI ID: 1477370

Report Number(s):: NREL/JA-6A60-72480

Journal Information:: Biomedical Optics Express, Journal Name: Biomedical Optics Express Vol. 9 Journal Issue: 9; ISSN 2156-7085

Publisher:: Optical Society of AmericaCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 15 works

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