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Title: T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability

Authors:
; ; ; ; ; ; ; ; ; ORCiD logo
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NIHOTHER
OSTI Identifier:
1474164
Resource Type:
Journal Article
Journal Name:
Nature Chemical Biology
Additional Journal Information:
Journal Volume: 14; Journal Issue: 10; Journal ID: ISSN 1552-4450
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Riley, Timothy P., Hellman, Lance M., Gee, Marvin H., Mendoza, Juan L., Alonso, Jesus A., Foley, Kendra C., Nishimura, Michael I., Vander Kooi, Craig W., Garcia, K. Christopher, and Baker, Brian M. T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability. United States: N. p., 2018. Web. doi:10.1038/s41589-018-0130-4.
Riley, Timothy P., Hellman, Lance M., Gee, Marvin H., Mendoza, Juan L., Alonso, Jesus A., Foley, Kendra C., Nishimura, Michael I., Vander Kooi, Craig W., Garcia, K. Christopher, & Baker, Brian M. T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability. United States. doi:10.1038/s41589-018-0130-4.
Riley, Timothy P., Hellman, Lance M., Gee, Marvin H., Mendoza, Juan L., Alonso, Jesus A., Foley, Kendra C., Nishimura, Michael I., Vander Kooi, Craig W., Garcia, K. Christopher, and Baker, Brian M. Mon . "T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability". United States. doi:10.1038/s41589-018-0130-4.
@article{osti_1474164,
title = {T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability},
author = {Riley, Timothy P. and Hellman, Lance M. and Gee, Marvin H. and Mendoza, Juan L. and Alonso, Jesus A. and Foley, Kendra C. and Nishimura, Michael I. and Vander Kooi, Craig W. and Garcia, K. Christopher and Baker, Brian M.},
abstractNote = {},
doi = {10.1038/s41589-018-0130-4},
journal = {Nature Chemical Biology},
issn = {1552-4450},
number = 10,
volume = 14,
place = {United States},
year = {2018},
month = {9}
}

Works referenced in this record:

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor
journal, July 2009

  • Cole, David K.; Yuan, Fang; Rizkallah, Pierre J.
  • Journal of Biological Chemistry, Vol. 284, Issue 40
  • DOI: 10.1074/jbc.M109.022509

A simple physical model for binding energy hot spots in protein-protein complexes
journal, October 2002

  • Kortemme, T.; Baker, D.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 22
  • DOI: 10.1073/pnas.202485799

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide
journal, June 2015

  • Motozono, Chihiro; Pearson, James A.; De Leenheer, Evy
  • Journal of Biological Chemistry, Vol. 290, Issue 31
  • DOI: 10.1074/jbc.M114.622522

Conformational changes and flexibility in T-cell receptor recognition of peptide–MHC complexes
journal, September 2008

  • Armstrong, Kathryn M.; Piepenbrink, Kurt H.; Baker, Brian M.
  • Biochemical Journal, Vol. 415, Issue 2
  • DOI: 10.1042/BJ20080850

Amino Acid Similarity Accounts for T Cell Cross-Reactivity and for “Holes” in the T Cell Repertoire
journal, March 2008


How tcrs bind Mhcs, Peptides, and Coreceptors
journal, April 2006


Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
journal, July 2009


How a Single T Cell Receptor Recognizes Both Self and Foreign MHC
journal, April 2007


HLA class I supertypes: a revised and updated classification
journal, January 2008


Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma
journal, March 2014


Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes
journal, September 2017

  • Singh, Nishant K.; Riley, Timothy P.; Baker, Sarah Catherine B.
  • The Journal of Immunology, Vol. 199, Issue 7
  • DOI: 10.4049/jimmunol.1700744

Degeneracy of Antigen Recognition as the Molecular Basis for the High Frequency of Naive A2/Melan-A Peptide Multimer + CD8 + T Cells in Humans
journal, July 2002

  • Dutoit, Valérie; Rubio-Godoy, Verena; Pittet, Mikäel J.
  • The Journal of Experimental Medicine, Vol. 196, Issue 2
  • DOI: 10.1084/jem.20020242

Structures of MART-126/27–35 Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition
journal, October 2007

  • Borbulevych, Oleg Y.; Insaidoo, Francis K.; Baxter, Tiffany K.
  • Journal of Molecular Biology, Vol. 372, Issue 5
  • DOI: 10.1016/j.jmb.2007.07.025

Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide–MHC complexes
journal, May 2016


T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus
journal, December 2017

  • Bovay, Amandine; Zoete, Vincent; Dolton, Garry
  • European Journal of Immunology, Vol. 48, Issue 2
  • DOI: 10.1002/eji.201747082

Broad Cross-Reactive TCR Repertoires Recognizing Dissimilar Epstein-Barr and Influenza A Virus Epitopes
journal, November 2010

  • Clute, Shalyn C.; Naumov, Yuri N.; Watkin, Levi B.
  • The Journal of Immunology, Vol. 185, Issue 11
  • DOI: 10.4049/jimmunol.1000812

Three-dimensional structure of a peptide extending from one end of a class I MHC binding site
journal, October 1994

  • Collins, Edward J.; Garboczi, David N.; Wiley, Don C.
  • Nature, Vol. 371, Issue 6498
  • DOI: 10.1038/371626a0

Circular dichroism determination of class I MHC-peptide equilibrium dissociation constants
journal, August 1997

  • Morgan, Chantal S.; Holton, James M.; Olafson, Barry D.
  • Protein Science, Vol. 6, Issue 8
  • DOI: 10.1002/pro.5560060819

A structural basis for immunodominant human T cell receptor recognition
journal, June 2003

  • Stewart-Jones, Guillaume B. E.; McMichael, Andrew J.; Bell, John I.
  • Nature Immunology, Vol. 4, Issue 7
  • DOI: 10.1038/ni942

Differential utilization of binding loop flexibility in T cell receptor ligand selection and cross-reactivity
journal, April 2016

  • Ayres, Cory M.; Scott, Daniel R.; Corcelli, Steven A.
  • Scientific Reports, Vol. 6, Issue 1
  • DOI: 10.1038/srep25070

T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility
journal, December 2009


Why must T cells be cross-reactive?
journal, August 2012

  • Sewell, Andrew K.
  • Nature Reviews Immunology, Vol. 12, Issue 9
  • DOI: 10.1038/nri3279

A very high level of crossreactivity is an essential feature of the T-cell receptor
journal, September 1998


Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability
journal, February 2016

  • Spear, Timothy T.; Riley, Timothy P.; Lyons, Gretchen E.
  • Journal of Leukocyte Biology, Vol. 100, Issue 3
  • DOI: 10.1189/jlb.2A1215-561R

Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes
journal, October 2006

  • Johnson, Laura A.; Heemskerk, Bianca; Powell, Daniel J.
  • The Journal of Immunology, Vol. 177, Issue 9
  • DOI: 10.4049/jimmunol.177.9.6548

Crystal Structures of Two Closely Related but Antigenically Distinct HLA-A2/Melanocyte-Melanoma Tumor-Antigen Peptide Complexes
journal, September 2001

  • Sliz, Piotr; Michielin, Olivier; Cerottini, Jean-Charles
  • The Journal of Immunology, Vol. 167, Issue 6
  • DOI: 10.4049/jimmunol.167.6.3276

Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity
journal, November 2015

  • Adams, Jarrett J.; Narayanan, Samanthi; Birnbaum, Michael E.
  • Nature Immunology, Vol. 17, Issue 1
  • DOI: 10.1038/ni.3310

Conformational Melding Permits a Conserved Binding Geometry in TCR Recognition of Foreign and Self Molecular Mimics
journal, January 2011

  • Borbulevych, Oleg Y.; Piepenbrink, Kurt H.; Baker, Brian M.
  • The Journal of Immunology, Vol. 186, Issue 5
  • DOI: 10.4049/jimmunol.1003150

Understanding the complexity and malleability of T-cell recognition
journal, January 2015

  • Miles, John J.; McCluskey, James; Rossjohn, Jamie
  • Immunology and Cell Biology, Vol. 93, Issue 5
  • DOI: 10.1038/icb.2014.112

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma
journal, August 2013


Polyspecificity of T cell and B cell receptor recognition
journal, August 2007


Macromolecular Modeling with Rosetta
journal, June 2008


T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules
journal, March 2015


Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
journal, May 2016

  • Cole, David K.; Bulek, Anna M.; Dolton, Garry
  • Journal of Clinical Investigation, Vol. 126, Issue 6
  • DOI: 10.1172/JCI85679

T Cell Allorecognition via Molecular Mimicry
journal, December 2009


How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire
journal, February 2016

  • Blevins, Sydney J.; Pierce, Brian G.; Singh, Nishant K.
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 9
  • DOI: 10.1073/pnas.1522069113

An Altered Position of the α2 Helix of MHC Class I Is Revealed by the Crystal Structure of HLA-B*3501
journal, March 1996


Distinct CDR3 Conformations in TCRs Determine the Level of Cross-Reactivity for Diverse Antigens, but Not the Docking Orientation
journal, October 2008


Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self
journal, October 2008

  • Mohammed, Fiyaz; Cobbold, Mark; Zarling, Angela L.
  • Nature Immunology, Vol. 9, Issue 11
  • DOI: 10.1038/ni.1660

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides
journal, November 2011

  • Wooldridge, Linda; Ekeruche-Makinde, Julia; van den Berg, Hugo A.
  • Journal of Biological Chemistry, Vol. 287, Issue 2
  • DOI: 10.1074/jbc.M111.289488

Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove
journal, January 2016


A T Cell Receptor CDR3β Loop Undergoes Conformational Changes of Unprecedented Magnitude Upon Binding to a Peptide/MHC Class I Complex
journal, March 2002


Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors
journal, July 2011

  • Pellicci, Daniel G.; Clarke, Andrew J.; Patel, Onisha
  • Nature Immunology, Vol. 12, Issue 9
  • DOI: 10.1038/ni.2076

A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene
journal, November 2017


Deconstructing the Peptide-MHC Specificity of T Cell Recognition
journal, May 2014


Positional Scanning-Synthetic Peptide Library-Based Analysis of Self- and Pathogen-Derived Peptide Cross-Reactivity with Tumor-Reactive Melan-A-Specific CTL
journal, November 2002


TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms
journal, July 2011

  • Borbulevych, Oleg Y.; Santhanagopolan, Sujatha M.; Hossain, Moushumi
  • The Journal of Immunology, Vol. 187, Issue 5
  • DOI: 10.4049/jimmunol.1101268

Two Different T Cell Receptors use Different Thermodynamic Strategies to Recognize the Same Peptide/MHC Ligand
journal, February 2005

  • Davis-Harrison, Rebecca L.; Armstrong, Kathryn M.; Baker, Brian M.
  • Journal of Molecular Biology, Vol. 346, Issue 2
  • DOI: 10.1016/j.jmb.2004.11.063

Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
journal, November 1996

  • Garboczi, David N.; Ghosh, Partho; Utz, Ursula
  • Nature, Vol. 384, Issue 6605
  • DOI: 10.1038/384134a0

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes
journal, January 2018


Using Global Analysis to Extend the Accuracy and Precision of Binding Measurements with T cell Receptors and Their Peptide/MHC Ligands
journal, January 2017


T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens
journal, June 2002

  • Brehm, Michael A.; Pinto, Amelia K.; Daniels, Keith A.
  • Nature Immunology, Vol. 3, Issue 7
  • DOI: 10.1038/ni806