Hydrogen evolution from water catalyzed by cobalt-mimochrome VI*a, a synthetic mini-protein

Firpo, Vincenzo; Le, Jennifer M.; Pavone, Vincenzo; Lombardi, Angela; Bren, Kara L.

doi:10.1039/C8SC01948G

Title: Hydrogen evolution from water catalyzed by cobalt-mimochrome VI*a, a synthetic mini-protein

Journal Article · Wed Nov 21 00:00:00 EST 2018 · Chemical Science

DOI:https://doi.org/10.1039/C8SC01948G· OSTI ID:1471784

Firpo, Vincenzo ^[1]; Le, Jennifer M. ^[2];

^[1];

^[2]

Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, 80126 Naples, Italy
Department of Chemistry, University of Rochester, Rochester, USA

A synthetic enzyme is reported that electrocatalytically reduces protons to hydrogen (H₂) in water near neutral pH under aerobic conditions. Cobalt mimochrome VI*a (CoMC6*a) is a mini-protein with a cobalt deuteroporphyrin active site within a scaffold of two synthetic peptides covalently bound to the porphyrin. Comparison of the activity of CoMC6*a to that of cobalt microperoxidase-11 (CoMP11-Ac), a cobalt porphyrin catalyst with a single “proximal” peptide and no organized secondary structure, reveals that CoMC6*a has significantly enhanced longevity, yielding a turnover number exceeding 230 000, in comparison to 25 000 for CoMP11-Ac. Furthermore, comparison of cyclic voltammograms of CoMC6*a and CoMP11-Ac indicates that the trifluoroethanol-induced folding of CoMC6*a lowers the overpotential for catalytic H₂ evolution by up to 100 mV. These results demonstrate that even a minimal polypeptide matrix can enhance longevity and efficiency of a H₂-evolution catalyst.

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Research Organization:: Univ. of Rochester, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: FG02-09ER16121; SC0002106

OSTI ID:: 1471784

Alternate ID(s):: OSTI ID: 1610622

Journal Information:: Chemical Science, Journal Name: Chemical Science Vol. 9 Journal Issue: 45; ISSN 2041-6520

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Cited by: 51 works

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