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Title: Response to Comment on "Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water"

Abstract

Bestet al. claim that we provide no convincing basis to assert that a discrepancy remains between FRET and SAXS results on the dimensions of disordered proteins under physiological conditions. We maintain that a clear discrepancy is apparent in our and other recent publications, including results shown in the Bestet al. comment. A plausible origin is fluorophore interactions in FRET experiments.

Authors:
ORCiD logo; ORCiD logo; ORCiD logo; ORCiD logo; ORCiD logo; ; ; ORCiD logo; ORCiD logo
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1471635
Resource Type:
Journal Article
Journal Name:
Science
Additional Journal Information:
Journal Volume: 361; Journal Issue: 6405; Journal ID: ISSN 0036-8075
Publisher:
AAAS
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Riback, Joshua A., Bowman, Micayla A., Zmyslowski, Adam, Knoverek, Catherine R., Jumper, John, Kaye, Emily B., Freed, Karl F., Clark, Patricia L., and Sosnick, Tobin R. Response to Comment on "Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water". United States: N. p., 2018. Web. doi:10.1126/science.aar7949.
Riback, Joshua A., Bowman, Micayla A., Zmyslowski, Adam, Knoverek, Catherine R., Jumper, John, Kaye, Emily B., Freed, Karl F., Clark, Patricia L., & Sosnick, Tobin R. Response to Comment on "Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water". United States. doi:10.1126/science.aar7949.
Riback, Joshua A., Bowman, Micayla A., Zmyslowski, Adam, Knoverek, Catherine R., Jumper, John, Kaye, Emily B., Freed, Karl F., Clark, Patricia L., and Sosnick, Tobin R. Thu . "Response to Comment on "Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water"". United States. doi:10.1126/science.aar7949.
@article{osti_1471635,
title = {Response to Comment on "Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water"},
author = {Riback, Joshua A. and Bowman, Micayla A. and Zmyslowski, Adam and Knoverek, Catherine R. and Jumper, John and Kaye, Emily B. and Freed, Karl F. and Clark, Patricia L. and Sosnick, Tobin R.},
abstractNote = {Bestet al. claim that we provide no convincing basis to assert that a discrepancy remains between FRET and SAXS results on the dimensions of disordered proteins under physiological conditions. We maintain that a clear discrepancy is apparent in our and other recent publications, including results shown in the Bestet al. comment. A plausible origin is fluorophore interactions in FRET experiments.},
doi = {10.1126/science.aar7949},
journal = {Science},
issn = {0036-8075},
number = 6405,
volume = 361,
place = {United States},
year = {2018},
month = {8}
}