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Title: The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor

Authors:
ORCiD logo; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NIHOTHERNIGMS
OSTI Identifier:
1471614
Resource Type:
Journal Article
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 8; Journal Issue: 1; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Frank, Filipp, Okafor, C. Denise, and Ortlund, Eric A. The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor. United States: N. p., 2018. Web. doi:10.1038/s41598-018-31812-9.
Frank, Filipp, Okafor, C. Denise, & Ortlund, Eric A. The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor. United States. doi:10.1038/s41598-018-31812-9.
Frank, Filipp, Okafor, C. Denise, and Ortlund, Eric A. Mon . "The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor". United States. doi:10.1038/s41598-018-31812-9.
@article{osti_1471614,
title = {The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor},
author = {Frank, Filipp and Okafor, C. Denise and Ortlund, Eric A.},
abstractNote = {},
doi = {10.1038/s41598-018-31812-9},
journal = {Scientific Reports},
issn = {2045-2322},
number = 1,
volume = 8,
place = {United States},
year = {2018},
month = {9}
}

Works referenced in this record:

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity
journal, April 2009


Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor
journal, April 2011


Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
journal, August 1991

  • Luisi, B. F.; Xu, W. X.; Otwinowski, Z.
  • Nature, Vol. 352, Issue 6335
  • DOI: 10.1038/352497a0

G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of Glucocorticoid Receptor target genes
journal, November 2012

  • Bittencourt, D.; Wu, D. -Y.; Jeong, K. W.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 48
  • DOI: 10.1073/pnas.1211803109

Solution structure of the glucocorticoid receptor DNA-binding domain
journal, July 1990


Molecular dynamics simulations of the glucocorticoid receptor DNA-binding domain suggest a role of the lever-arm mobility in transcriptional output
journal, December 2017


Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes
journal, March 1977

  • Ryckaert, Jean-Paul; Ciccotti, Giovanni; Berendsen, Herman J. C.
  • Journal of Computational Physics, Vol. 23, Issue 3
  • DOI: 10.1016/0021-9991(77)90098-5

MMTSB Tool Set: enhanced sampling and multiscale modeling methods for applications in structural biology
journal, May 2004

  • Feig, Michael; Karanicolas, John; Brooks, Charles L.
  • Journal of Molecular Graphics and Modelling, Vol. 22, Issue 5
  • DOI: 10.1016/j.jmgm.2003.12.005

PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production
journal, May 2016

  • Morgan, David J.; Poolman, Toryn M.; Williamson, Andrew J. K.
  • Scientific Reports, Vol. 6, Issue 1
  • DOI: 10.1038/srep26419

Glucocorticoid receptor control of transcription: precision and plasticity via allostery
journal, January 2017

  • Weikum, Emily R.; Knuesel, Matthew T.; Ortlund, Eric A.
  • Nature Reviews Molecular Cell Biology, Vol. 18, Issue 3
  • DOI: 10.1038/nrm.2016.152

Cooperativity and specificity in the interactions between DNA and the glucocorticoid receptor DNA binding domain
journal, June 1990

  • Haerd, Torleif; Dahlman, Karin; Carlstedt-Duke, Jan
  • Biochemistry, Vol. 29, Issue 22
  • DOI: 10.1021/bi00474a022

Role of the N-Terminal Activation Domain of the Coiled-Coil Coactivator in Mediating Transcriptional Activation by β-Catenin
journal, December 2006

  • Yang, Catherine K.; Kim, Jeong Hoon; Stallcup, Michael R.
  • Molecular Endocrinology, Vol. 20, Issue 12
  • DOI: 10.1210/me.2006-0200

Refined solution structure of the glucocorticoid receptor DNA-binding domain
journal, December 1993

  • Baumann, Herbert; Paulsen, Kim; Kovacs, Helena
  • Biochemistry, Vol. 32, Issue 49
  • DOI: 10.1021/bi00212a011

The structural basis of direct glucocorticoid-mediated transrepression
journal, December 2012

  • Hudson, William H.; Youn, Christine; Ortlund, Eric A.
  • Nature Structural & Molecular Biology, Vol. 20, Issue 1
  • DOI: 10.1038/nsmb.2456

The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals
journal, June 2013

  • Watson, Lisa C.; Kuchenbecker, Kristopher M.; Schiller, Benjamin J.
  • Nature Structural & Molecular Biology, Vol. 20, Issue 7
  • DOI: 10.1038/nsmb.2595

Structural Survey of Zinc-Containing Proteins and Development of the Zinc AMBER Force Field (ZAFF)
journal, August 2010

  • Peters, Martin B.; Yang, Yue; Wang, Bing
  • Journal of Chemical Theory and Computation, Vol. 6, Issue 9
  • DOI: 10.1021/ct1002626

Anti-inflammatory glucocorticoid drugs: reflections after 60 years
journal, October 2010


GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression
journal, December 2008

  • Chinenov, Y.; Sacta, M. A.; Cruz, A. R.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 51
  • DOI: 10.1073/pnas.0810863105

Therapeutic Mechanisms of Glucocorticoids
journal, January 2018

  • Vandewalle, Jolien; Luypaert, Astrid; De Bosscher, Karolien
  • Trends in Endocrinology & Metabolism, Vol. 29, Issue 1
  • DOI: 10.1016/j.tem.2017.10.010

Structural Determinants of a Glucocorticoid Receptor Recognition Element
journal, December 1990

  • Nordeen, Steven K.; Suh, Betty J.; Kühnel, Blanka
  • Molecular Endocrinology, Vol. 4, Issue 12
  • DOI: 10.1210/mend-4-12-1866

Identification and characterization of BATF3 as a context-specific coactivator of the glucocorticoid receptor
journal, July 2017


Mutations in the glucocorticoid receptor DNA-binding domain mimic an allosteric effect of DNA 1 1Edited by P. E. Wright
journal, August 2000

  • van Tilborg, M. A. A.; Lefstin, J. A.; Kruiskamp, M.
  • Journal of Molecular Biology, Vol. 301, Issue 4
  • DOI: 10.1006/jmbi.2000.4001

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
journal, June 2013

  • Roe, Daniel R.; Cheatham, Thomas E.
  • Journal of Chemical Theory and Computation, Vol. 9, Issue 7
  • DOI: 10.1021/ct400341p

Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts
journal, December 2002

  • Rogatsky, I.; Luecke, H. F.; Leitman, D. C.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 26
  • DOI: 10.1073/pnas.262671599