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Title: Variations in nuclear localization strategies among pol X family enzymes

Authors:
ORCiD logo [1]; ORCiD logo [1];  [1]; ORCiD logo [2]; ORCiD logo [1]
  1. National Institute of Environmental Health Sciences, Genome Integrity and Structural Biology Laboratory, National Institutes of Health, Research Triangle Park North Carolina
  2. Molecular & Metabolic Oncology, University of South Alabama Mitchell Cancer Institute, Mobile Alabama
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
UNIVERSITYNIH
OSTI Identifier:
1471606
Resource Type:
Journal Article
Journal Name:
Traffic
Additional Journal Information:
Journal Volume: 19; Journal Issue: 9; Journal ID: ISSN 1398-9219
Publisher:
Wiley
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Kirby, Thomas W., Pedersen, Lars C., Gabel, Scott A., Gassman, Natalie R., and London, Robert E. Variations in nuclear localization strategies among pol X family enzymes. United States: N. p., 2018. Web. doi:10.1111/tra.12600.
Kirby, Thomas W., Pedersen, Lars C., Gabel, Scott A., Gassman, Natalie R., & London, Robert E. Variations in nuclear localization strategies among pol X family enzymes. United States. doi:10.1111/tra.12600.
Kirby, Thomas W., Pedersen, Lars C., Gabel, Scott A., Gassman, Natalie R., and London, Robert E. Wed . "Variations in nuclear localization strategies among pol X family enzymes". United States. doi:10.1111/tra.12600.
@article{osti_1471606,
title = {Variations in nuclear localization strategies among pol X family enzymes},
author = {Kirby, Thomas W. and Pedersen, Lars C. and Gabel, Scott A. and Gassman, Natalie R. and London, Robert E.},
abstractNote = {},
doi = {10.1111/tra.12600},
journal = {Traffic},
issn = {1398-9219},
number = 9,
volume = 19,
place = {United States},
year = {2018},
month = {7}
}

Works referenced in this record:

PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization
journal, January 1999


Nuclear localization signals and human disease
journal, July 2009

  • McLane, Laura M.; Corbett, Anita H.
  • IUBMB Life, Vol. 61, Issue 7
  • DOI: 10.1002/iub.194

Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms
journal, August 2004

  • Girard, Pierre-Marie; Kysela, Boris; Härer, Christine J.
  • Human Molecular Genetics, Vol. 13, Issue 20
  • DOI: 10.1093/hmg/ddh274

Phospholipid Scramblase 1 Contains a Nonclassical Nuclear Localization Signal with Unique Binding Site in Importin α
journal, December 2004

  • Chen, Min-Hsuan; Ben-Efraim, Iris; Mitrousis, Gregory
  • Journal of Biological Chemistry, Vol. 280, Issue 11
  • DOI: 10.1074/jbc.M413194200

Solution Structure of Polymerase μ's BRCT Domain Reveals an Element Essential for Its Role in Nonhomologous End Joining
journal, October 2007

  • DeRose, Eugene F.; Clarkson, Michael W.; Gilmore, Steven A.
  • Biochemistry, Vol. 46, Issue 43
  • DOI: 10.1021/bi7007728

A Biochemically Defined System for Mammalian Nonhomologous DNA End Joining
journal, December 2004


The maximal size of protein to diffuse through the nuclear pore is larger than 60 kDa
journal, June 2007


Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS
journal, August 2015

  • Kirby, Thomas W.; Gassman, Natalie R.; Smith, Cassandra E.
  • Scientific Reports, Vol. 5, Issue 1
  • DOI: 10.1038/srep13405

A Minimal Nuclear Localization Signal (NLS) in Human Phospholipid Scramblase 4 That Binds Only the Minor NLS-binding Site of Importin α1
journal, June 2011

  • Lott, Kaylen; Bhardwaj, Anshul; Sims, Peter J.
  • Journal of Biological Chemistry, Vol. 286, Issue 32
  • DOI: 10.1074/jbc.M111.228007

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
journal, July 2010

  • Dormann, Dorothee; Rodde, Ramona; Edbauer, Dieter
  • The EMBO Journal, Vol. 29, Issue 16
  • DOI: 10.1038/emboj.2010.143

Importin α Nuclear Localization Signal Binding Sites for STAT1, STAT2, and Influenza A Virus Nucleoprotein
journal, May 2003

  • Melén, Krister; Fagerlund, Riku; Franke, Jacqueline
  • Journal of Biological Chemistry, Vol. 278, Issue 30
  • DOI: 10.1074/jbc.M303571200

Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-α11Edited by K. Nagai
journal, April 2000

  • Fontes, Marcos R. M.; Teh, Trazel; Kobe, Bostjan
  • Journal of Molecular Biology, Vol. 297, Issue 5
  • DOI: 10.1006/jmbi.2000.3642

DNA polymerase β contains a functional nuclear localization signal at its N-terminus
journal, December 2016

  • Kirby, Thomas W.; Gassman, Natalie R.; Smith, Cassandra E.
  • Nucleic Acids Research, Vol. 45, Issue 4
  • DOI: 10.1093/nar/gkw1257

Six Classes of Nuclear Localization Signals Specific to Different Binding Grooves of Importin α
journal, November 2008

  • Kosugi, Shunichi; Hasebe, Masako; Matsumura, Nobutaka
  • Journal of Biological Chemistry, Vol. 284, Issue 1
  • DOI: 10.1074/jbc.M807017200

NLStradamus: a simple Hidden Markov Model for nuclear localization signal prediction
journal, January 2009

  • Nguyen Ba, Alex N.; Pogoutse, Anastassia; Provart, Nicholas
  • BMC Bioinformatics, Vol. 10, Issue 1
  • DOI: 10.1186/1471-2105-10-202

Large-Scale Conformational Dynamics Control H5N1 Influenza Polymerase PB2 Binding to Importin α
journal, October 2015

  • Delaforge, Elise; Milles, Sigrid; Bouvignies, Guillaume
  • Journal of the American Chemical Society, Vol. 137, Issue 48
  • DOI: 10.1021/jacs.5b07765

Nuclear translocation contributes to regulation of DNA excision repair activities
journal, June 2009


Hop-on hop-off: importin-α-guided tours to the nucleus in innate immune signaling
journal, January 2013

  • Wirthmueller, Lennart; Roth, Charlotte; Banfield, Mark J.
  • Frontiers in Plant Science, Vol. 4
  • DOI: 10.3389/fpls.2013.00149

Functional analysis of the C-terminal region of human adenovirus E1A reveals a misidentified nuclear localization signal
journal, November 2014


Mutational Analysis of Terminal Deoxynucleotidyltransferase- Mediated N-Nucleotide Addition in V(D)J Recombination
journal, April 2004

  • Repasky, Jamie A. E.; Corbett, Elizabeth; Boboila, Cristian
  • The Journal of Immunology, Vol. 172, Issue 9
  • DOI: 10.4049/jimmunol.172.9.5478

NLSdb—major update for database of nuclear localization signals and nuclear export signals
journal, November 2017

  • Bernhofer, Michael; Goldberg, Tatyana; Wolf, Silvana
  • Nucleic Acids Research, Vol. 46, Issue D1
  • DOI: 10.1093/nar/gkx1021

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair
journal, February 2016

  • Crespan, Emmanuele; Furrer, Antonia; Rösinger, Marcel
  • Nature Communications, Vol. 7, Issue 1
  • DOI: 10.1038/ncomms10805

Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin α1
journal, November 2017


Classical Nuclear Localization Signals: Definition, Function, and Interaction with Importin α
journal, December 2006

  • Lange, Allison; Mills, Ryan E.; Lange, Christopher J.
  • Journal of Biological Chemistry, Vol. 282, Issue 8
  • DOI: 10.1074/jbc.R600026200

Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-α
journal, October 2003

  • Fontes, Marcos R. M.; Teh, Trazel; Toth, Gabor
  • Biochemical Journal, Vol. 375, Issue 2
  • DOI: 10.1042/bj20030510

Importin-α Protein Binding to a Nuclear Localization Signal of Carbohydrate Response Element-Binding Protein (ChREBP)
journal, June 2011

  • Ge, Qiang; Nakagawa, Tsutomu; Wynn, R. Max
  • Journal of Biological Chemistry, Vol. 286, Issue 32
  • DOI: 10.1074/jbc.M111.237016

Novel Binding of the Mitotic Regulator TPX2 (Target Protein for Xenopus Kinesin-like Protein 2) to Importin-α
journal, March 2010

  • Giesecke, Astrid; Stewart, Murray
  • Journal of Biological Chemistry, Vol. 285, Issue 23
  • DOI: 10.1074/jbc.M110.102343

A probabilistic model of nuclear import of proteins
journal, March 2011


A comparison of BRCT domains involved in nonhomologous end-joining: Introducing the solution structure of the BRCT domain of polymerase lambda
journal, August 2008


Distribution and roles of X-family DNA polymerases in eukaryotes
journal, February 2009


Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase   binding affinity
journal, March 2010

  • Cuneo, M. J.; London, R. E.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 15
  • DOI: 10.1073/pnas.0914077107

Structural basis for the nuclear import of the human androgen receptor
journal, March 2008

  • Cutress, M. L.; Whitaker, H. C.; Mills, I. G.
  • Journal of Cell Science, Vol. 121, Issue 7
  • DOI: 10.1242/jcs.022103

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

Correlation of Phenotype/Genotype in a Cohort of 23 Xeroderma Pigmentosum-Variant Patients Reveals 12 New Disease-Causing POLH Mutations
journal, November 2013

  • Opletalova, Kristina; Bourillon, Agnès; Yang, Wei
  • Human Mutation, Vol. 35, Issue 1
  • DOI: 10.1002/humu.22462

ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor
journal, February 2016

  • Divisato, Giuseppina; Formicola, Daniela; Esposito, Teresa
  • The American Journal of Human Genetics, Vol. 98, Issue 2
  • DOI: 10.1016/j.ajhg.2015.12.016

Over-expression of human DNA polymerase lambda in E. coli and characterization of the recombinant enzyme
journal, July 2002


Spectroscopic Determination of Tryptophan and Tyrosine in Proteins *
journal, July 1967


Evidence That the Long Murine Terminal Deoxynucleotidyltransferase Isoform Plays No Role in the Control of V(D)J Junctional Diversity
journal, May 2004


PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Protein N-Terminal Processing: Substrate Specificity of Escherichia coli and Human Methionine Aminopeptidases
journal, July 2010

  • Xiao, Qing; Zhang, Feiran; Nacev, Benjamin A.
  • Biochemistry, Vol. 49, Issue 26
  • DOI: 10.1021/bi1005464

Evaluation of parameter uncertainties in nonlinear regression using Microsoft Excel Spreadsheet
journal, January 2015


Sensing actin dynamics: Structural basis for G-actin-sensitive nuclear import of MAL
journal, October 2011

  • Hirano, Hidemi; Matsuura, Yoshiyuki
  • Biochemical and Biophysical Research Communications, Vol. 414, Issue 2
  • DOI: 10.1016/j.bbrc.2011.09.079

Structural Biology and Regulation of Protein Import into the Nucleus
journal, May 2016

  • Christie, Mary; Chang, Chiung-Wen; Róna, Gergely
  • Journal of Molecular Biology, Vol. 428, Issue 10
  • DOI: 10.1016/j.jmb.2015.10.023

DNA Polymerases β and λ Mediate Overlapping and Independent Roles in Base Excision Repair in Mouse Embryonic Fibroblasts
journal, August 2010


Design Rules for Selective Binding of Nuclear Localization Signals to Minor Site of Importin α
journal, March 2014


XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair
journal, July 2010


DNA polymerase Family X: Function, structure, and cellular roles
journal, May 2010

  • Yamtich, Jennifer; Sweasy, Joann B.
  • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1804, Issue 5
  • DOI: 10.1016/j.bbapap.2009.07.008

Protein localization in disease and therapy
journal, October 2011

  • Hung, M. -C.; Link, W.
  • Journal of Cell Science, Vol. 124, Issue 20
  • DOI: 10.1242/jcs.089110

A sulfoglycolipid beta-sulfoquinovosyldiacylglycerol ( SQDG) binds to Met1-Arg95 region of murine DNA polymerase lambda (Mmpol  ) and inhibits its nuclear transit
journal, November 2009

  • Takakusagi, K.; Takakusagi, Y.; Ohta, K.
  • Protein Engineering Design and Selection, Vol. 23, Issue 2
  • DOI: 10.1093/protein/gzp064

Sequence requirements for synthetic peptide-mediated translocation to the nucleus.
journal, June 1989

  • Chelsky, D.; Ralph, R.; Jonak, G.
  • Molecular and Cellular Biology, Vol. 9, Issue 6
  • DOI: 10.1128/MCB.9.6.2487

HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β
journal, November 2014

  • Fang, Qingming; Inanc, Burcu; Schamus, Sandy
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms6513

The X family portrait: Structural insights into biological functions of X family polymerases
journal, December 2007


Association of DNA Polymerase   (pol  ) with Ku and Ligase IV: Role for pol   in End-Joining Double-Strand Break Repair
journal, July 2002


Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling
journal, October 2005


Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206

Noncatalytic, N-terminal Domains of DNA Polymerase Lambda Affect Its Cellular Localization and DNA Damage Response
journal, April 2017


The DNA-polymerase-X family: controllers of DNA quality?
journal, December 2004

  • Ramadan, Kristijan; Shevelev, Igor; Hübscher, Ulrich
  • Nature Reviews Molecular Cell Biology, Vol. 5, Issue 12
  • DOI: 10.1038/nrm1530