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Title: Mastering the non-equilibrium assembly and operation of molecular machines


External fluctuations can drive formation of a non-equilibrium steady state.

 [1];  [1]; ORCiD logo [1]; ORCiD logo [2]
  1. Department of Chemistry; Northwestern University; Evanston; USA
  2. Department of Physics; University of Maine; Orono; USA
Publication Date:
Research Org.:
Energy Frontier Research Centers (EFRC) (United States). Center for Bio-Inspired Energy Science (CBES)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
DOE Contract Number:  
Resource Type:
Journal Article
Journal Name:
Chemical Society Reviews
Additional Journal Information:
Journal Volume: 46; Journal Issue: 18; Related Information: CBES partners with Northwestern University (lead); Harvard University; New York University; Pennsylvania State University; University of Michigan; University of Pittsburgh; Journal ID: ISSN 0306-0012
Royal Society of Chemistry
Country of Publication:
United States
catalysis (homogeneous), solar (photovoltaic), bio-inspired, charge transport, mesostructured materials, materials and chemistry by design, synthesis (novel materials), synthesis (self-assembly)

Citation Formats

Pezzato, Cristian, Cheng, Chuyang, Stoddart, J. Fraser, and Astumian, R. Dean. Mastering the non-equilibrium assembly and operation of molecular machines. United States: N. p., 2017. Web. doi:10.1039/c7cs00068e.
Pezzato, Cristian, Cheng, Chuyang, Stoddart, J. Fraser, & Astumian, R. Dean. Mastering the non-equilibrium assembly and operation of molecular machines. United States. doi:10.1039/c7cs00068e.
Pezzato, Cristian, Cheng, Chuyang, Stoddart, J. Fraser, and Astumian, R. Dean. Sun . "Mastering the non-equilibrium assembly and operation of molecular machines". United States. doi:10.1039/c7cs00068e.
title = {Mastering the non-equilibrium assembly and operation of molecular machines},
author = {Pezzato, Cristian and Cheng, Chuyang and Stoddart, J. Fraser and Astumian, R. Dean},
abstractNote = {External fluctuations can drive formation of a non-equilibrium steady state.},
doi = {10.1039/c7cs00068e},
journal = {Chemical Society Reviews},
issn = {0306-0012},
number = 18,
volume = 46,
place = {United States},
year = {2017},
month = {1}

Works referenced in this record:

The stochastic pump effect and geometric phases in dissipative and stochastic systems
journal, April 2009

Imposed oscillations of kinetic barriers can cause an enzyme to drive a chemical reaction away from equilibrium
journal, December 1993

  • Astumian, R. Dean; Robertson, Baldwin
  • Journal of the American Chemical Society, Vol. 115, Issue 24
  • DOI: 10.1021/ja00077a001

Stochastic thermodynamics, fluctuation theorems and molecular machines
journal, November 2012

“If Pigs Could Fly” Chemistry: A Tutorial on the Principle of Microscopic Reversibility
journal, December 2008

  • Blackmond, Donna G.
  • Angewandte Chemie International Edition, Vol. 48, Issue 15
  • DOI: 10.1002/anie.200804566

From Chemistry to Biochemistry to Catalysis to Movement
journal, June 1997

Photoactivated Directionally Controlled Transit of a Non-Symmetric Molecular Axle Through a Macrocycle
journal, March 2012

  • Baroncini, Massimo; Silvi, Serena; Venturi, Margherita
  • Angewandte Chemie International Edition, Vol. 51, Issue 17
  • DOI: 10.1002/anie.201200555

Relative Unidirectional Translation in an Artificial Molecular Assembly Fueled by Light
journal, November 2013

  • Li, Hao; Cheng, Chuyang; McGonigal, Paul R.
  • Journal of the American Chemical Society, Vol. 135, Issue 49
  • DOI: 10.1021/ja4094204

Energetically Demanding Transport in a Supramolecular Assembly
journal, October 2014

  • Cheng, Chuyang; McGonigal, Paul R.; Liu, Wei-Guang
  • Journal of the American Chemical Society, Vol. 136, Issue 42
  • DOI: 10.1021/ja508615f

Adiabatic operation of a molecular machine
journal, December 2007

Kinetic Master Equation Modeling of an Artificial Protein Pump
journal, June 2016

  • Zhang, Yu; Lai, Cheng-Tsung; Hinds, Bruce J.
  • The Journal of Physical Chemistry C, Vol. 120, Issue 27
  • DOI: 10.1021/acs.jpcc.6b03076

Effects of oscillations and energy-driven fluctuations on the dynamics of enzyme catalysis and free-energy transduction
journal, June 1989

A chemically powered unidirectional rotary molecular motor based on a palladium redox cycle
journal, June 2016

  • Collins, Beatrice S. L.; Kistemaker, Jos C. M.; Otten, Edwin
  • Nature Chemistry, Vol. 8, Issue 9
  • DOI: 10.1038/nchem.2543

Intrawell relaxation of overdamped Brownian particles
journal, June 1999

Stochastic Conformational Pumping: A Mechanism for Free-Energy Transduction by Molecules
journal, June 2011

Fluctuation driven transport and models of molecular motors and pumps
journal, August 1998

  • Astumian, R. D.; Derényi, Imre
  • European Biophysics Journal, Vol. 27, Issue 5
  • DOI: 10.1007/s002490050158

An artificial molecular pump
journal, May 2015

  • Cheng, Chuyang; McGonigal, Paul R.; Schneebeli, Severin T.
  • Nature Nanotechnology, Vol. 10, Issue 6
  • DOI: 10.1038/nnano.2015.96

Directed Flow in Nonadiabatic Stochastic Pumps
journal, October 2008

Universal Geometric Theory of Mesoscopic Stochastic Pumps and Reversible Ratchets
journal, November 2007

Great expectations: can artificial molecular machines deliver on their promise?
journal, January 2012

  • Coskun, Ali; Banaszak, Michal; Astumian, R. Dean
  • Chem. Soc. Rev., Vol. 41, Issue 1
  • DOI: 10.1039/C1CS15262A

Light-powered autonomous and directional molecular motion of a dissipative self-assembling system
journal, November 2014

  • Ragazzon, Giulio; Baroncini, Massimo; Silvi, Serena
  • Nature Nanotechnology, Vol. 10, Issue 1
  • DOI: 10.1038/nnano.2014.260

A Three-Compartment Chemically-Driven Molecular Information Ratchet
journal, May 2012

  • Carlone, Armando; Goldup, Stephen M.; Lebrasseur, Nathalie
  • Journal of the American Chemical Society, Vol. 134, Issue 20
  • DOI: 10.1021/ja302711z

A molecular shuttle
journal, June 1991

  • Anelli, Pier Lucio; Spencer, Neil; Stoddart, J. Fraser
  • Journal of the American Chemical Society, Vol. 113, Issue 13
  • DOI: 10.1021/ja00013a096

How Should We Think About the Ribosome?
journal, June 2012

Modeling ion channels: Past, present, and future
journal, June 2014

Fluctuations and Irreversible Processes
journal, September 1953

The Physics and Physical Chemistry of Molecular Machines
journal, June 2016

  • Astumian, R. Dean; Mukherjee, Shayantani; Warshel, Arieh
  • ChemPhysChem, Vol. 17, Issue 12
  • DOI: 10.1002/cphc.201600184

Artificial Molecular-Level Machines:  Which Energy To Make Them Work?
journal, June 2001

  • Ballardini, Roberto; Balzani, Vincenzo; Credi, Alberto
  • Accounts of Chemical Research, Vol. 34, Issue 6
  • DOI: 10.1021/ar000170g

An autonomous chemically fuelled small-molecule motor
journal, June 2016

  • Wilson, Miriam R.; Solà, Jordi; Carlone, Armando
  • Nature, Vol. 534, Issue 7606
  • DOI: 10.1038/nature18013

The load dependence of rate constants
journal, June 2008

  • Walcott, Sam
  • The Journal of Chemical Physics, Vol. 128, Issue 21
  • DOI: 10.1063/1.2920475

Design and Synthesis of Nonequilibrium Systems
journal, August 2015

Unlikely Fluctuations and Non-Equilibrium Work Theorems—A Simple Example
journal, June 2016

Adiabatic Pumping Mechanism for Ion Motive ATPases
journal, September 2003

Perspectives in Chemistry-Steps towards Complex Matter
journal, February 2013

Wholly Synthetic Molecular Machines
journal, March 2016

Stochastic pumping of ions based on colored noise in bacterial channels under acidic stress
journal, January 2016

  • López, M. Lidón; Queralt-Martín, María; Alcaraz, Antonio
  • Nanoscale, Vol. 8, Issue 27
  • DOI: 10.1039/C6NR02638A

Ultrafast dynamics in the power stroke of a molecular rotary motor
journal, May 2012

  • Conyard, Jamie; Addison, Kiri; Heisler, Ismael A.
  • Nature Chemistry, Vol. 4, Issue 7
  • DOI: 10.1038/nchem.1343

Biological Proton Pumping in an Oscillating Electric Field
journal, December 2009

Une nouvelle famille de molecules : les metallo-catenanes
journal, January 1983

Controlling Motion at the Nanoscale: Rise of the Molecular Machines
journal, July 2015

  • Abendroth, John M.; Bushuyev, Oleksandr S.; Weiss, Paul S.
  • ACS Nano, Vol. 9, Issue 8
  • DOI: 10.1021/acsnano.5b03367

Molecular motors
journal, April 2003

Electroconformational coupling and membrane protein function
journal, January 1987

Life at low Reynolds number
journal, January 1977

  • Purcell, E. M.
  • American Journal of Physics, Vol. 45, Issue 1
  • DOI: 10.1119/1.10903

A Redox-Active Bistable Molecular Switch Mounted inside a Metal–Organic Framework
journal, October 2016

  • Chen, Qishui; Sun, Junling; Li, Peng
  • Journal of the American Chemical Society, Vol. 138, Issue 43
  • DOI: 10.1021/jacs.6b09880

Microscopic reversibility as the organizing principle of molecular machines
journal, November 2012

Artificial Molecular Machines
journal, August 2015