Synthesis of Self-Assembled Porphyrin Nanoparticle Photosensitizers
[1];
[2];
[3]
- Henan Univ., Kaifeng (China). Key Lab. for Special Functional Materials of the Ministry of Education. Collaborative Innovation Center of Nano Functional Materials and Applications
- National Center for Nanoscience and Technology (NCNST), Beijing (China). CAS Key Lab. for Biological Effects of Nanomaterials and Nanosafety
- Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Chemical and Biological Engineering; Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
The use of nanoparticles as a potential building block for photosensitizers has recently become a focus of interest in the field of photocatalysis and photodynamic therapy. Porphyrins and their derivatives are effective photosensitizers due to extended π-conjugated electronic structure, high molar absorption from visible to near-infrared spectrum, and high singlet oxygen quantum yields as well as chemical versatility. In this work, we report a synthesis of self-assembled porphyrin nanoparticle photosensitizers using zinc meso-tetra(4-pyridyl)porphyrin (ZnTPyP) through a confined noncovalent self-assembly process. Scanning electron microscopy reveals formation of monodisperse cubic nanoparticles. UV–vis characterizations reveal that optical absorption of the nanoparticles exhibits a red shift due to noncovalent self-assembly of porphyrins, which not only effectively increase intensity of light absorption but also extend light absorption broadly covering visible light for enhanced photodynamic therapy. Electron spin-resonance spectroscopy (ESR) studies show the resultant porphyrin nanoparticles release a high yield of singlet oxygen. Nitric oxide (NO) coordinates to central metal Zn ions to form stabilized ZnTPyP@NO nanoparticles. We show that under light irradiation ZnTPyP@NO nanoparticles release highly reactive peroxynitrite molecules that exhibit enhanced antibacterial photodynamic therapy (APDT) activity. Finally, the ease of the synthesis of self-assembled porphyrin nanoparticles and light-triggered release of highly reactive moieties represent a completely different photosensitizer system for APDT application.
- Research Organization:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Henan Univ., Kaifeng (China); National Center for Nanoscience and Technology (NCNST), Beijing (China)
- Sponsoring Organization:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE National Nuclear Security Administration (NNSA); National Natural Science Foundation of China (NSFC); Plan for Scientific Innovation Talent of Henan Province (China); Program for Changjiang Scholars and Innovative Research Team in University (China)
- Grant/Contract Number:
- NA0003525; 21422102; 21771055; U1604139; 21171049; 174200510019; PCS IRT_15R18
- OSTI ID:
- 1469627
- Report Number(s):
- SAND-2018-9735J; 667620
- Journal Information:
- ACS Nano, Vol. 12, Issue 4; ISSN 1936-0851
- Publisher:
- American Chemical Society (ACS)Copyright Statement
- Country of Publication:
- United States
- Language:
- English
Web of Science
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