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Title: A plant-responsive bacterial-signaling system senses an ethanolamine derivative

Abstract

A number of plant-associated bacteria possess transcription factors homologous to LuxR that respond to compounds found in plant tissue. These LuxR homologs are known to regulate virulence or symbiosis. Although the first of these proteins were described more than a decade ago, the factors they respond to remain unknown. Here we identify a compound that functions with PipR, a plant-responsive LuxR homolog from a tree root endopytic Pseudomonas isolate. The inducer is an ethanolamine derivative. Ethanolamine is a building block for plant membrane phospholipids and signaling molecules. As a result, this discovery connects at least one of the plant-responsive LuxR homolog systems to a growing understanding of ethanolamine chemistry and responses of bacterial cells to ethanolamine and ethanolamine derivatives.

Authors:
 [1];  [2];  [1]; ORCiD logo [3]; ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [1]
  1. Univ. of Washington, Seattle, WA (United States)
  2. Harvard Medical School, Boston, MA (United States)
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1468883
Alternate Identifier(s):
OSTI ID: 1474576
Grant/Contract Number:  
AC05-00OR22725; AC05-00R227525
Resource Type:
Journal Article: Published Article
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Additional Journal Information:
Journal Volume: 115; Journal Issue: 39; Journal ID: ISSN 0027-8424
Publisher:
National Academy of Sciences, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ethanolamine; LuxR homolog; plant–microbe interactions; transcription activator; quorum sensing

Citation Formats

Coutinho, Bruna G., Mevers, Emily, Schaefer, Amy L., Pelletier, Dale A., Harwood, Caroline S., Clardy, Jon, and Greenberg, E. Peter. A plant-responsive bacterial-signaling system senses an ethanolamine derivative. United States: N. p., 2018. Web. doi:10.1073/pnas.1809611115.
Coutinho, Bruna G., Mevers, Emily, Schaefer, Amy L., Pelletier, Dale A., Harwood, Caroline S., Clardy, Jon, & Greenberg, E. Peter. A plant-responsive bacterial-signaling system senses an ethanolamine derivative. United States. doi:10.1073/pnas.1809611115.
Coutinho, Bruna G., Mevers, Emily, Schaefer, Amy L., Pelletier, Dale A., Harwood, Caroline S., Clardy, Jon, and Greenberg, E. Peter. Thu . "A plant-responsive bacterial-signaling system senses an ethanolamine derivative". United States. doi:10.1073/pnas.1809611115.
@article{osti_1468883,
title = {A plant-responsive bacterial-signaling system senses an ethanolamine derivative},
author = {Coutinho, Bruna G. and Mevers, Emily and Schaefer, Amy L. and Pelletier, Dale A. and Harwood, Caroline S. and Clardy, Jon and Greenberg, E. Peter},
abstractNote = {A number of plant-associated bacteria possess transcription factors homologous to LuxR that respond to compounds found in plant tissue. These LuxR homologs are known to regulate virulence or symbiosis. Although the first of these proteins were described more than a decade ago, the factors they respond to remain unknown. Here we identify a compound that functions with PipR, a plant-responsive LuxR homolog from a tree root endopytic Pseudomonas isolate. The inducer is an ethanolamine derivative. Ethanolamine is a building block for plant membrane phospholipids and signaling molecules. As a result, this discovery connects at least one of the plant-responsive LuxR homolog systems to a growing understanding of ethanolamine chemistry and responses of bacterial cells to ethanolamine and ethanolamine derivatives.},
doi = {10.1073/pnas.1809611115},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
issn = {0027-8424},
number = 39,
volume = 115,
place = {United States},
year = {2018},
month = {9}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1073/pnas.1809611115

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Works referenced in this record:

Plants Synthesize Ethanolamine by Direct Decarboxylation of Serine Using a Pyridoxal Phosphate Enzyme
journal, July 2001

  • Rontein, Denis; Nishida, Ikuo; Tashiro, Gen
  • Journal of Biological Chemistry, Vol. 276, Issue 38, p. 35523-35529
  • DOI: 10.1074/jbc.M106038200