A plant-responsive bacterial-signaling system senses an ethanolamine derivative

Coutinho, Bruna G.; Mevers, Emily; Schaefer, Amy L.; Pelletier, Dale A.; Harwood, Caroline S.; Clardy, Jon; Greenberg, E. Peter

doi:10.1073/pnas.1809611115

Title: A plant-responsive bacterial-signaling system senses an ethanolamine derivative

Journal Article · Thu Sep 06 00:00:00 EDT 2018 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.1809611115· OSTI ID:1468883

Coutinho, Bruna G. ^[1]; Mevers, Emily ^[2]; Schaefer, Amy L. ^[1]; Pelletier, Dale A. ^[3];

^[1];

^[2];

^[1]

Department of Microbiology, University of Washington, Seattle, WA 98195,
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115,
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830

Significance A number of plant-associated bacteria possess transcription factors homologous to LuxR that respond to compounds found in plant tissue. These LuxR homologs are known to regulate virulence or symbiosis. Although the first of these proteins were described more than a decade ago, the factors they respond to remain unknown. Here we identify a compound that functions with PipR, a plant-responsive LuxR homolog from a tree root endopytic Pseudomonas isolate. The inducer is an ethanolamine derivative. Ethanolamine is a building block for plant membrane phospholipids and signaling molecules. This discovery connects at least one of the plant-responsive LuxR homolog systems to a growing understanding of ethanolamine chemistry and responses of bacterial cells to ethanolamine and ethanolamine derivatives.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-00R227525; AC05-00OR22725

OSTI ID:: 1468883

Alternate ID(s):: OSTI ID: 1474576

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Vol. 115 Journal Issue: 39; ISSN 0027-8424

Publisher:: Proceedings of the National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 27 works

Citation information provided by
Web of Science

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59 BASIC BIOLOGICAL SCIENCES
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quorum sensing

Title: A plant-responsive bacterial-signaling system senses an ethanolamine derivative

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