skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein

Authors:
; ; ; ORCiD logo; ORCiD logo; ; ; ; ; ORCiD logo; ; ORCiD logo; ORCiD logo; ORCiD logo
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NIHOTHER
OSTI Identifier:
1468818
Resource Type:
Journal Article
Journal Name:
Nature Structural & Molecular Biology
Additional Journal Information:
Journal Volume: 25; Journal Issue: 7; Journal ID: ISSN 1545-9993
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Botuyan, Maria Victoria, Cui, Gaofeng, Drané, Pascal, Oliveira, Catarina, Detappe, Alexandre, Brault, Marie Eve, Parnandi, Nishita, Chaubey, Shweta, Thompson, James R., Bragantini, Benoît, Zhao, Debiao, Chapman, J. Ross, Chowdhury, Dipanjan, and Mer, Georges. Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. United States: N. p., 2018. Web. doi:10.1038/s41594-018-0083-z.
Botuyan, Maria Victoria, Cui, Gaofeng, Drané, Pascal, Oliveira, Catarina, Detappe, Alexandre, Brault, Marie Eve, Parnandi, Nishita, Chaubey, Shweta, Thompson, James R., Bragantini, Benoît, Zhao, Debiao, Chapman, J. Ross, Chowdhury, Dipanjan, & Mer, Georges. Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. United States. doi:10.1038/s41594-018-0083-z.
Botuyan, Maria Victoria, Cui, Gaofeng, Drané, Pascal, Oliveira, Catarina, Detappe, Alexandre, Brault, Marie Eve, Parnandi, Nishita, Chaubey, Shweta, Thompson, James R., Bragantini, Benoît, Zhao, Debiao, Chapman, J. Ross, Chowdhury, Dipanjan, and Mer, Georges. Sun . "Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein". United States. doi:10.1038/s41594-018-0083-z.
@article{osti_1468818,
title = {Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein},
author = {Botuyan, Maria Victoria and Cui, Gaofeng and Drané, Pascal and Oliveira, Catarina and Detappe, Alexandre and Brault, Marie Eve and Parnandi, Nishita and Chaubey, Shweta and Thompson, James R. and Bragantini, Benoît and Zhao, Debiao and Chapman, J. Ross and Chowdhury, Dipanjan and Mer, Georges},
abstractNote = {},
doi = {10.1038/s41594-018-0083-z},
journal = {Nature Structural & Molecular Biology},
issn = {1545-9993},
number = 7,
volume = 25,
place = {United States},
year = {2018},
month = {7}
}

Works referenced in this record:

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair
journal, December 2006


Tandem Protein Interaction Modules Organize the Ubiquitin-Dependent Response to DNA Double-Strand Breaks
journal, August 2012


53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
journal, June 2013

  • Fradet-Turcotte, Amélie; Canny, Marella D.; Escribano-Díaz, Cristina
  • Nature, Vol. 499, Issue 7456
  • DOI: 10.1038/nature12318

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency
journal, November 2017

  • Canny, Marella D.; Moatti, Nathalie; Wan, Leo C. K.
  • Nature Biotechnology, Vol. 36, Issue 1
  • DOI: 10.1038/nbt.4021

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest
journal, April 2010

  • Iyama, Teruaki; Abolhassani, Nona; Tsuchimoto, Daisuke
  • Nucleic Acids Research, Vol. 38, Issue 14
  • DOI: 10.1093/nar/gkq249

Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18
journal, May 2017


53BP1 is required for class switch recombination
journal, May 2004

  • Ward, Irene M.; Reina-San-Martin, Bernardo; Olaru, Alexandru
  • The Journal of Cell Biology, Vol. 165, Issue 4
  • DOI: 10.1083/jcb.200403021

Structural Plasticity of Methyllysine Recognition by the Tandem Tudor Domain of 53BP1
journal, February 2015


53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
journal, May 2010

  • Bouwman, Peter; Aly, Amal; Escandell, Jose M.
  • Nature Structural & Molecular Biology, Vol. 17, Issue 6
  • DOI: 10.1038/nsmb.1831

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling
journal, September 2012


Senescence Induced by Altered Telomere State, Not Telomere Loss
journal, March 2002


The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres
journal, June 2010


Using Prior Knowledge in the Determination of Macromolecular Size-Distributions by Analytical Ultracentrifugation
journal, June 2007

  • Brown, Patrick H.; Balbo, Andrea; Schuck, Peter
  • Biomacromolecules, Vol. 8, Issue 6
  • DOI: 10.1021/bm070193j

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination
journal, April 2004

  • Manis, John P.; Morales, Julio C.; Xia, Zhenfang
  • Nature Immunology, Vol. 5, Issue 5
  • DOI: 10.1038/ni1067

p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice
journal, April 2003


NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals
journal, January 2010

  • Abolhassani, Nona; Iyama, Teruaki; Tsuchimoto, Daisuke
  • Nucleic Acids Research, Vol. 38, Issue 9
  • DOI: 10.1093/nar/gkp1250

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase
journal, July 2012

  • Gatti, Marco; Pinato, Sabrina; Maspero, Elena
  • Cell Cycle, Vol. 11, Issue 13
  • DOI: 10.4161/cc.20919

An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks
journal, December 2008

  • Zgheib, O.; Pataky, K.; Brugger, J.
  • Molecular and Cellular Biology, Vol. 29, Issue 4
  • DOI: 10.1128/MCB.01011-08

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination
journal, February 2013

  • Tang, Jiangbo; Cho, Nam Woo; Cui, Gaofeng
  • Nature Structural & Molecular Biology, Vol. 20, Issue 3
  • DOI: 10.1038/nsmb.2499

Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor
journal, December 2007

  • Lee, Joseph; Thompson, James R.; Botuyan, Maria Victoria
  • Nature Structural & Molecular Biology, Vol. 15, Issue 1
  • DOI: 10.1038/nsmb1326

Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining
journal, April 2015

  • Zong, Dali; Callén, Elsa; Pegoraro, Gianluca
  • Nucleic Acids Research, Vol. 43, Issue 10
  • DOI: 10.1093/nar/gkv336

DNA Ligase IV-Dependent NHEJ of Deprotected Mammalian Telomeres in G1 and G2
journal, October 2002


The structural basis of modified nucleosome recognition by 53BP1
journal, July 2016

  • Wilson, Marcus D.; Benlekbir, Samir; Fradet-Turcotte, Amélie
  • Nature, Vol. 536, Issue 7614
  • DOI: 10.1038/nature18951

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation
journal, May 2016


RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair
journal, March 2013

  • Feng, Lin; Fong, Ka-Wing; Wang, Jiadong
  • Journal of Biological Chemistry, Vol. 288, Issue 16
  • DOI: 10.1074/jbc.M113.457440

Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage
journal, June 2017

  • Burger, Kaspar; Schlackow, Margarita; Potts, Martin
  • The Journal of Cell Biology, Vol. 216, Issue 8
  • DOI: 10.1083/jcb.201612131

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3
journal, May 2010

  • Drane, P.; Ouararhni, K.; Depaux, A.
  • Genes & Development, Vol. 24, Issue 12
  • DOI: 10.1101/gad.566910

The p53-binding protein 1-Tudor-interacting repair regulator complex participates in the DNA damage response
journal, February 2017

  • Zhang, Aili; Peng, Bo; Huang, Ping
  • Journal of Biological Chemistry, Vol. 292, Issue 16
  • DOI: 10.1074/jbc.M117.777474

Structural basis of UGUA recognition by the Nudix protein CFIm25 and implications for a regulatory role in mRNA 3' processing
journal, May 2010

  • Yang, Q.; Gilmartin, G. M.; Doublie, S.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 22
  • DOI: 10.1073/pnas.1000848107

Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions
journal, March 2014


TIRR regulates 53BP1 by masking its histone methyl-lysine binding function
journal, February 2017

  • Drané, Pascal; Brault, Marie-Eve; Cui, Gaofeng
  • Nature, Vol. 543, Issue 7644
  • DOI: 10.1038/nature21358

Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1
journal, May 2011


Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks
journal, April 2012

  • Poulsen, Maria; Lukas, Claudia; Lukas, Jiri
  • The Journal of Cell Biology, Vol. 197, Issue 2
  • DOI: 10.1083/jcb.201109100

Crystal structure of syndesmos and its interaction with Syndecan-4 proteoglycan
journal, August 2015

  • Kim, Heeyoun; Yoo, Jiho; Lee, Inhwan
  • Biochemical and Biophysical Research Communications, Vol. 463, Issue 4
  • DOI: 10.1016/j.bbrc.2015.06.010

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites: RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A
journal, February 2012

  • Mallette, Frédérick A.; Mattiroli, Francesca; Cui, Gaofeng
  • The EMBO Journal, Vol. 31, Issue 8
  • DOI: 10.1038/emboj.2012.47

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA
journal, January 2011


Processing of protein ADP-ribosylation by Nudix hydrolases
journal, May 2015

  • Palazzo, Luca; Thomas, Benjamin; Jemth, Ann-Sofie
  • Biochemical Journal, Vol. 468, Issue 2
  • DOI: 10.1042/BJ20141554

Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
journal, November 2017

  • Michelini, Flavia; Pitchiaya, Sethuramasundaram; Vitelli, Valerio
  • Nature Cell Biology, Vol. 19, Issue 12
  • DOI: 10.1038/ncb3643

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks
journal, November 2011

  • Acs, Klara; Luijsterburg, Martijn S.; Ackermann, Leena
  • Nature Structural & Molecular Biology, Vol. 18, Issue 12
  • DOI: 10.1038/nsmb.2188

The Tandem BRCT Domain of 53BP1 Is Not Required for Its Repair Function
journal, October 2006

  • Ward, Irene; Kim, Ja-Eun; Minn, Kay
  • Journal of Biological Chemistry, Vol. 281, Issue 50
  • DOI: 10.1074/jbc.M607577200

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions
journal, June 2013


Dephosphorylation Enables the Recruitment of 53BP1 to Double-Strand DNA Breaks
journal, May 2014


53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
journal, April 2010


PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
journal, October 2008

  • Dimitrova, Nadya; Chen, Yi-Chun M.; Spector, David L.
  • Nature, Vol. 456, Issue 7221
  • DOI: 10.1038/nature07433

Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme
journal, September 2008

  • Taylor, Melissa J.; Peculis, Brenda A.
  • Nucleic Acids Research, Vol. 36, Issue 18
  • DOI: 10.1093/nar/gkn605

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate
journal, June 2015


High-Resolution Mapping of RNA-Binding Regions in the Nuclear Proteome of Embryonic Stem Cells
journal, October 2016


Site-specific DICER and DROSHA RNA products control the DNA-damage response
journal, May 2012

  • Francia, Sofia; Michelini, Flavia; Saxena, Alka
  • Nature, Vol. 488, Issue 7410
  • DOI: 10.1038/nature11179

Double-strand break repair: 53BP1 comes into focus
journal, December 2013

  • Panier, Stephanie; Boulton, Simon J.
  • Nature Reviews Molecular Cell Biology, Vol. 15, Issue 1
  • DOI: 10.1038/nrm3719

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice
journal, March 2013

  • Escribano-Díaz, Cristina; Orthwein, Alexandre; Fradet-Turcotte, Amélie
  • Molecular Cell, Vol. 49, Issue 5
  • DOI: 10.1016/j.molcel.2013.01.001

Ring Finger Protein RNF169 Antagonizes the Ubiquitin-dependent Signaling Cascade at Sites of DNA Damage
journal, June 2012

  • Chen, Jie; Feng, Wanjuan; Jiang, Jun
  • Journal of Biological Chemistry, Vol. 287, Issue 33
  • DOI: 10.1074/jbc.M112.373530

Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe
journal, January 2018