skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1467727
Resource Type:
Journal Article
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 8; Journal Issue: 1; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Rechkoblit, Olga, Choudhury, Jayati Roy, Buku, Angeliki, Prakash, Louise, Prakash, Satya, and Aggarwal, Aneel K. Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine. United States: N. p., 2018. Web. doi:10.1038/s41598-018-30796-w.
Rechkoblit, Olga, Choudhury, Jayati Roy, Buku, Angeliki, Prakash, Louise, Prakash, Satya, & Aggarwal, Aneel K. Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine. United States. doi:10.1038/s41598-018-30796-w.
Rechkoblit, Olga, Choudhury, Jayati Roy, Buku, Angeliki, Prakash, Louise, Prakash, Satya, and Aggarwal, Aneel K. Thu . "Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine". United States. doi:10.1038/s41598-018-30796-w.
@article{osti_1467727,
title = {Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine},
author = {Rechkoblit, Olga and Choudhury, Jayati Roy and Buku, Angeliki and Prakash, Louise and Prakash, Satya and Aggarwal, Aneel K.},
abstractNote = {},
doi = {10.1038/s41598-018-30796-w},
journal = {Scientific Reports},
issn = {2045-2322},
number = 1,
volume = 8,
place = {United States},
year = {2018},
month = {8}
}

Works referenced in this record:

Effects of the O2' hydroxyl group on Z-DNA conformation: structure of Z-RNA and (araC)-[Z-DNA]
journal, June 1989

  • Teng, Mai Kun; Liaw, Yen Chywan; Van der Marel, Gijs A.
  • Biochemistry, Vol. 28, Issue 12
  • DOI: 10.1021/bi00438a001

Overview of the CCP 4 suite and current developments
journal, March 2011

  • Winn, Martyn D.; Ballard, Charles C.; Cowtan, Kevin D.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4
  • DOI: 10.1107/S0907444910045749

Structural Impact of the Leukemia Drug 1-β-d-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex
journal, January 2003

  • Chrencik, Jill E.; Burgin, Alex B.; Pommier, Yves
  • Journal of Biological Chemistry, Vol. 278, Issue 14
  • DOI: 10.1074/jbc.M212930200

Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases
journal, July 2007

  • Berman, Andrea J.; Kamtekar, Satwik; Goodman, Jessica L.
  • The EMBO Journal, Vol. 26, Issue 14
  • DOI: 10.1038/sj.emboj.7601780

Exonucleases and the incorporation of aranucleotides into DNA
journal, October 1999

  • Perrino, Fred W.; Mazur, Dan J.; Ward, Heather
  • Cell Biochemistry and Biophysics, Vol. 30, Issue 3
  • DOI: 10.1007/BF02738118

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

A Novel Role of DNA Polymerase   in Modulating Cellular Sensitivity to Chemotherapeutic Agents
journal, April 2006


Functional consequences of the arabinosylcytosine structural lesion in DNA
journal, June 1988


Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution
journal, January 1998

  • Doublié, Sylvie; Tabor, Stanley; Long, Alexander M.
  • Nature, Vol. 391, Issue 6664
  • DOI: 10.1038/34593

Structure and mechanism of human DNA polymerase η
journal, June 2010

  • Biertümpfel, Christian; Zhao, Ye; Kondo, Yuji
  • Nature, Vol. 465, Issue 7301
  • DOI: 10.1038/nature09196

Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations
journal, March 2003

  • Johnson, S. J.; Taylor, J. S.; Beese, L. S.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 7
  • DOI: 10.1073/pnas.0630532100

Progress in Acute Myeloid Leukemia
journal, March 2015

  • Kadia, Tapan M.; Ravandi, Farhad; O'Brien, Susan
  • Clinical Lymphoma Myeloma and Leukemia, Vol. 15, Issue 3
  • DOI: 10.1016/j.clml.2014.08.006

The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)
journal, March 2017


PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy
journal, May 2012

  • Ummat, Ajay; Rechkoblit, Olga; Jain, Rinku
  • Nature Structural & Molecular Biology, Vol. 19, Issue 6
  • DOI: 10.1038/nsmb.2295

Effect of ara-C incorporation on deoxyribonucleic acid synthesis in cells
journal, September 1982


Structure of the Replicating Complex of a Pol α Family DNA Polymerase
journal, June 2001


Structural Insight into Translesion Synthesis by DNA Pol II
journal, December 2009


Incorporation of Gemcitabine and Cytarabine into DNA by DNA Polymerase β and Ligase III/XRCC1
journal, June 2010

  • Prakasha Gowda, A. S.; Polizzi, Joanna M.; Eckert, Kristin A.
  • Biochemistry, Vol. 49, Issue 23
  • DOI: 10.1021/bi100200c

Role of the catalytic metal during polymerization by DNA polymerase lambda
journal, September 2007


Eukaryotic DNA polymerases
journal, December 2018

  • Jain, Rinku; Aggarwal, Aneel K.; Rechkoblit, Olga
  • Current Opinion in Structural Biology, Vol. 53
  • DOI: 10.1016/j.sbi.2018.06.003

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ
journal, August 2009

  • Swan, Michael K.; Johnson, Robert E.; Prakash, Louise
  • Nature Structural & Molecular Biology, Vol. 16, Issue 9
  • DOI: 10.1038/nsmb.1663

Mechanism of somatic hypermutation at the WA motif by human DNA polymerase  
journal, April 2013

  • Zhao, Y.; Gregory, M. T.; Biertumpfel, C.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 20
  • DOI: 10.1073/pnas.1303126110

DNA Polymerases Divide the Labor of Genome Replication
journal, September 2016

  • Lujan, Scott A.; Williams, Jessica S.; Kunkel, Thomas A.
  • Trends in Cell Biology, Vol. 26, Issue 9
  • DOI: 10.1016/j.tcb.2016.04.012

Watching DNA polymerase η make a phosphodiester bond
journal, July 2012

  • Nakamura, Teruya; Zhao, Ye; Yamagata, Yuriko
  • Nature, Vol. 487, Issue 7406
  • DOI: 10.1038/nature11181

Cytarabine dose in the consolidation treatment of AML: a systematic review and meta-analysis
journal, August 2017


EUKARYOTIC TRANSLESION SYNTHESIS DNA POLYMERASES: Specificity of Structure and Function
journal, June 2005


Effect of Cytarabine on the NMR Structure of a Model Okazaki Fragment from the SV40 Genome
journal, January 1999

  • Gmeiner, William H.; Konerding, David; James, Thomas L.
  • Biochemistry, Vol. 38, Issue 4
  • DOI: 10.1021/bi981702s

Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206

Magnesium-Induced Assembly of a Complete DNA Polymerase Catalytic Complex
journal, April 2006