Statistical analysis of the chemical attribution signatures of 3-methylfentanyl and its methods of production

Journal Article · Mon Feb 12 00:00:00 EST 2018 · Talanta

DOI:https://doi.org/10.1016/j.talanta.2018.02.026· OSTI ID:1466937

Mayer, Brian P. ^[1]; Valdez, Carlos A. ^[1]; DeHope, Alan J. ^[2]; Spackman, Paul E. ^[1]; Williams, Audrey M. ^[1]

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1. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Forensic Science Center
2. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Materials Science Division

Chemical attribution of the origin of an illegal drug is a key component of forensic efforts aimed at combating illicit and clandestine manufacture of drugs and pharmaceuticals. The results of these studies yield detailed information on synthesis byproducts, reagents, and precursors that can be used to identify the method of manufacture. Here in the present work, chemical attribution signatures (CAS) associated with the synthesis of the analgesic 3-methylfentanyl, N-(3-methyl-1-phenethylpiperidin-4-yl)-N-phenylpropanamide, were investigated. Eighteen crude samples from six synthesis methods were generated, the analysis of which was used to identify signatures (i.e. chemical compounds) that were important in the discrimination of synthetic route. These methods were carefully selected to minimize the use of scheduled precursors, complicated laboratory equipment, number of steps, and extreme reaction conditions. Using gas and liquid chromatographies combined with time-of-flight mass spectrometry (GC-QTOF and LC-QTOF) over 160 distinct species were monitored. Lastly, analysis of this combined data set was performed using modern machine learning techniques capable of reducing the size of the data set, prioritizing key chemical attribution signatures, and identifying the method of production for blindly synthesized 3-methylfentanyl materials.

• Research Organization: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
• Sponsoring Organization: USDOE National Nuclear Security Administration (NNSA)
• Grant/Contract Number: AC52-07NA27344
• OSTI ID: 1466937
• Alternate ID(s): OSTI ID: 1523332
• Report Number(s): LLNL-JRNL-739013; 892228
• Journal Information: Talanta, Vol. 186, Issue C; ISSN 0039-9140
• Publisher: Elsevier
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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Machine learning
3-methylfentanyl
Forensic attribution
Chemical forensics
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