skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Human N -acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite

Authors:
; ; ; ; ; ; ; ; ORCiD logo
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1464834
Resource Type:
Journal Article
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Additional Journal Information:
Journal Volume: 115; Journal Issue: (18) ; 05, 2018; Journal ID: ISSN 0027-8424
Publisher:
National Academy of Sciences, Washington, DC (United States)
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Kadirvelraj, Renuka, Yang, Jeong-Yeh, Sanders, Justin H., Liu, Lin, Ramiah, Annapoorani, Prabhakar, Pradeep Kumar, Boons, Geert-Jan, Wood, Zachary A., and Moremen, Kelley W. Human N -acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite. United States: N. p., 2018. Web. doi:10.1073/pnas.1716988115.
Kadirvelraj, Renuka, Yang, Jeong-Yeh, Sanders, Justin H., Liu, Lin, Ramiah, Annapoorani, Prabhakar, Pradeep Kumar, Boons, Geert-Jan, Wood, Zachary A., & Moremen, Kelley W. Human N -acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite. United States. doi:10.1073/pnas.1716988115.
Kadirvelraj, Renuka, Yang, Jeong-Yeh, Sanders, Justin H., Liu, Lin, Ramiah, Annapoorani, Prabhakar, Pradeep Kumar, Boons, Geert-Jan, Wood, Zachary A., and Moremen, Kelley W. Mon . "Human N -acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite". United States. doi:10.1073/pnas.1716988115.
@article{osti_1464834,
title = {Human N -acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite},
author = {Kadirvelraj, Renuka and Yang, Jeong-Yeh and Sanders, Justin H. and Liu, Lin and Ramiah, Annapoorani and Prabhakar, Pradeep Kumar and Boons, Geert-Jan and Wood, Zachary A. and Moremen, Kelley W.},
abstractNote = {},
doi = {10.1073/pnas.1716988115},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
issn = {0027-8424},
number = (18) ; 05, 2018,
volume = 115,
place = {United States},
year = {2018},
month = {4}
}

Works referenced in this record:

Golgi N -Glycosyltransferases Form Both Homo- and Heterodimeric Enzyme Complexes in Live Cells
journal, April 2010

  • Hassinen, Antti; Rivinoja, Antti; Kauppila, Annika
  • Journal of Biological Chemistry, Vol. 285, Issue 23
  • DOI: 10.1074/jbc.M110.103184

Vertebrate protein glycosylation: diversity, synthesis and function
journal, June 2012

  • Moremen, Kelley W.; Tiemeyer, Michael; Nairn, Alison V.
  • Nature Reviews Molecular Cell Biology, Vol. 13, Issue 7
  • DOI: 10.1038/nrm3383

An Evolving Hierarchical Family Classification for Glycosyltransferases
journal, April 2003


Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis
journal, September 2013

  • Striebeck, Alexander; Robinson, David A.; Schüttelkopf, Alexander W.
  • Open Biology, Vol. 3, Issue 9
  • DOI: 10.1098/rsob.130022

Congenital disorders of glycosylation IIa cause growth retardation, mental retardation, and facial dysmorphism
journal, November 2000


Congenital disorder of glycosylation IIa: The trouble with diagnosing a dysmorphic inborn error of metabolism
journal, November 2011

  • Alazami, Anas M.; Monies, Dorota; Meyer, Brian F.
  • American Journal of Medical Genetics Part A, Vol. 158A, Issue 1
  • DOI: 10.1002/ajmg.a.34347

Glycosyltransferases: Structures, Functions, and Mechanisms
journal, June 2008


Protein stability promotes evolvability
journal, March 2006

  • Bloom, J. D.; Labthavikul, S. T.; Otey, C. R.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 15, p. 5869-5874
  • DOI: 10.1073/pnas.0510098103

Polder maps: improving OMIT maps by excluding bulk solvent
journal, February 2017

  • Liebschner, Dorothee; Afonine, Pavel V.; Moriarty, Nigel W.
  • Acta Crystallographica Section D Structural Biology, Vol. 73, Issue 2, p. 148-157
  • DOI: 10.1107/S2059798316018210

Biological roles of glycans
journal, August 2016


Dali server: conservation mapping in 3D
journal, May 2010

  • Holm, Liisa; Rosenstr�m, P�ivi
  • Nucleic Acids Research, Vol. 38, Issue suppl_2
  • DOI: 10.1093/nar/gkq366

Golgi  -mannosidase II cleaves two sugars sequentially in the same catalytic site
journal, July 2008

  • Shah, N.; Kuntz, D. A.; Rose, D. R.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 28
  • DOI: 10.1073/pnas.0802206105

Carbohydrate-deficient glycoprotein syndrome type II
journal, October 1999

  • Schachter, Harry; Jaeken, Jaak
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1455, Issue 2-3
  • DOI: 10.1016/S0925-4439(99)00054-X

Expression system for structural and functional studies of human glycosylation enzymes
journal, December 2017

  • Moremen, Kelley W.; Ramiah, Annapoorani; Stuart, Melissa
  • Nature Chemical Biology, Vol. 14, Issue 2
  • DOI: 10.1038/nchembio.2539

Evolutionary Forces Shaping the Golgi Glycosylation Machinery: Why Cell Surface Glycans Are Universal to Living Cells
journal, April 2011


Carbohydrate-binding domain of the POMGnT1 stem region modulates O -mannosylation sites of α-dystroglycan
journal, August 2016

  • Kuwabara, Naoyuki; Manya, Hiroshi; Yamada, Takeyuki
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 33
  • DOI: 10.1073/pnas.1525545113

Synthetic substrate analogues for UDP-GlcNAc: Manα1-6R β(1-2)-N-acetylglucosaminyltransferase II. Substrate specificity and inhibitors for the enzyme
journal, June 1994

  • Reck, Folkert; Meinjohanns, Ernst; Springer, Matthias
  • Glycoconjugate Journal, Vol. 11, Issue 3
  • DOI: 10.1007/BF00731220

The ‘yellow brick road’ to branched complex N -glycans
journal, January 1991


Synthetic substrate analogues for UDP-GlcNAc: Man?1-3R ?1-2-N-acetylglucosaminyltransferase I. Substrate specificity and inhibitors for the enzyme
journal, December 1995

  • Reck, Folkert; Springer, Matthias; Meinjohanns, Ernst
  • Glycoconjugate Journal, Vol. 12, Issue 6
  • DOI: 10.1007/BF00731234