skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

Authors:
ORCiD logo; ORCiD logo; ORCiD logo; ORCiD logo; ORCiD logo; ; ORCiD logo; ORCiD logo; ORCiD logo; ; ORCiD logo; ORCiD logo; ORCiD logo; ORCiD logo; ORCiD logo; ORCiD logo
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NIHFOREIGNOTHER
OSTI Identifier:
1463743
Resource Type:
Journal Article
Journal Name:
Science
Additional Journal Information:
Journal Volume: 360; Journal Issue: 6395; Journal ID: ISSN 0036-8075
Publisher:
AAAS
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Imkeller, Katharina, Scally, Stephen W., Bosch, Alexandre, Martí, Gemma Pidelaserra, Costa, Giulia, Triller, Gianna, Murugan, Rajagopal, Renna, Valerio, Jumaa, Hassan, Kremsner, Peter G., Sim, B. Kim Lee, Hoffman, Stephen L., Mordmüller, Benjamin, Levashina, Elena A., Julien, Jean-Philippe, and Wardemann, Hedda. Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope. United States: N. p., 2018. Web. doi:10.1126/science.aar5304.
Imkeller, Katharina, Scally, Stephen W., Bosch, Alexandre, Martí, Gemma Pidelaserra, Costa, Giulia, Triller, Gianna, Murugan, Rajagopal, Renna, Valerio, Jumaa, Hassan, Kremsner, Peter G., Sim, B. Kim Lee, Hoffman, Stephen L., Mordmüller, Benjamin, Levashina, Elena A., Julien, Jean-Philippe, & Wardemann, Hedda. Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope. United States. doi:10.1126/science.aar5304.
Imkeller, Katharina, Scally, Stephen W., Bosch, Alexandre, Martí, Gemma Pidelaserra, Costa, Giulia, Triller, Gianna, Murugan, Rajagopal, Renna, Valerio, Jumaa, Hassan, Kremsner, Peter G., Sim, B. Kim Lee, Hoffman, Stephen L., Mordmüller, Benjamin, Levashina, Elena A., Julien, Jean-Philippe, and Wardemann, Hedda. Thu . "Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope". United States. doi:10.1126/science.aar5304.
@article{osti_1463743,
title = {Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope},
author = {Imkeller, Katharina and Scally, Stephen W. and Bosch, Alexandre and Martí, Gemma Pidelaserra and Costa, Giulia and Triller, Gianna and Murugan, Rajagopal and Renna, Valerio and Jumaa, Hassan and Kremsner, Peter G. and Sim, B. Kim Lee and Hoffman, Stephen L. and Mordmüller, Benjamin and Levashina, Elena A. and Julien, Jean-Philippe and Wardemann, Hedda},
abstractNote = {},
doi = {10.1126/science.aar5304},
journal = {Science},
issn = {0036-8075},
number = 6395,
volume = 360,
place = {United States},
year = {2018},
month = {6}
}

Works referenced in this record:

Predominant Autoantibody Production by Early Human B Cell Precursors
journal, September 2003


Immune mechanisms in malaria: new insights in vaccine development
journal, February 2013

  • Riley, Eleanor M.; Stewart, V. Ann
  • Nature Medicine, Vol. 19, Issue 2
  • DOI: 10.1038/nm.3083

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection
journal, December 2013

  • Foquet, Lander; Hermsen, Cornelus C.; van Gemert, Geert-Jan
  • Journal of Clinical Investigation, Vol. 124, Issue 1
  • DOI: 10.1172/JCI70349

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning
journal, January 2008

  • Tiller, Thomas; Meffre, Eric; Yurasov, Sergey
  • Journal of Immunological Methods, Vol. 329, Issue 1-2
  • DOI: 10.1016/j.jim.2007.09.017

A Bayesian View on Cryo-EM Structure Determination
journal, January 2012


Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein
journal, November 2017

  • Oyen, David; Torres, Jonathan L.; Wille-Reece, Ulrike
  • Proceedings of the National Academy of Sciences, Vol. 114, Issue 48
  • DOI: 10.1073/pnas.1715812114

Collaboration gets the most out of software
journal, September 2013


Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493

PANDAseq: paired-end assembler for illumina sequences
journal, January 2012

  • Masella, Andre P.; Bartram, Andrea K.; Truszkowski, Jakub M.
  • BMC Bioinformatics, Vol. 13, Issue 1
  • DOI: 10.1186/1471-2105-13-31

Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum
journal, January 2006

  • Ghasparian, Arin; Moehle, Kerstin; Linden, Anthony
  • Chem. Commun., Issue 2
  • DOI: 10.1039/B510812H

Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data
journal, January 2013


PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Sterile protection against human malaria by chemoattenuated PfSPZ vaccine
journal, February 2017

  • Mordmüller, Benjamin; Surat, Güzin; Lagler, Heimo
  • Nature, Vol. 542, Issue 7642
  • DOI: 10.1038/nature21060

Autoreactive B Cell Receptors Mimic Autonomous Pre-B Cell Receptor Signaling and Induce Proliferation of Early B Cells
journal, December 2008


Clonal selection drives protective memory B cell responses in controlled human malaria infection
journal, February 2018


T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein
journal, July 2017


Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data: Table 1.
journal, June 2015


Complete Haplotype Sequence of the Human Immunoglobulin Heavy-Chain Variable, Diversity, and Joining Genes and Characterization of Allelic and Copy-Number Variation
journal, April 2013

  • Watson, Corey T.; Steinberg, Karyn M.; Huddleston, John
  • The American Journal of Human Genetics, Vol. 92, Issue 4
  • DOI: 10.1016/j.ajhg.2013.03.004

Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite
journal, January 1980


Repetitive sequences in malaria parasite proteins
journal, October 2017

  • Davies, Heledd M.; Nofal, Stephanie D.; McLaughlin, Emilia J.
  • FEMS Microbiology Reviews, Vol. 41, Issue 6
  • DOI: 10.1093/femsre/fux046

Conventional Light Chains Inhibit the Autonomous Signaling Capacity of the B Cell Receptor
journal, March 2007


XDS
journal, January 2010

  • Kabsch, Wolfgang
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2
  • DOI: 10.1107/S0907444909047337

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein
journal, March 2018

  • Tan, Joshua; Sack, Brandon K.; Oyen, David
  • Nature Medicine, Vol. 24, Issue 4
  • DOI: 10.1038/nm.4513

In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire
journal, December 2014

  • DeKosky, Brandon J.; Kojima, Takaaki; Rodin, Alexa
  • Nature Medicine, Vol. 21, Issue 1
  • DOI: 10.1038/nm.3743

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
journal, March 2018

  • Kisalu, Neville K.; Idris, Azza H.; Weidle, Connor
  • Nature Medicine, Vol. 24, Issue 4
  • DOI: 10.1038/nm.4512

Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation
journal, February 2016

  • Hattori, Takamitsu; Lai, Darson; Dementieva, Irina S.
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 8
  • DOI: 10.1073/pnas.1522691113

DNA cloning of Plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope
journal, August 1984


Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies
journal, December 2017


Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206