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Title: Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery

Abstract

The precise delivery of biofunctionalized matters is of great interest from the fundamental and applied viewpoints. In spite of significant progress achieved during the last decade, a parallel and automated isolation and manipulation of rare analyte, and their simultaneous on-chip separation and trapping, still remain challenging. In this work, a universal micromagnet junction for self-navigating gates of microrobotic particles to deliver the biomolecules to specific sites using a remote magnetic field is described. In the proposed concept, the nonmagnetic gap between the lithographically defined donor and acceptor micromagnets creates a crucial energy barrier to restrict particle gating. It is shown that by carefully designing the geometry of the junctions, it becomes possible to deliver multiple protein-functionalized carriers in high resolution, as well as MCF-7 and THP-1 cells from the mixture, with high fidelity and trap them in individual apartments. Integration of such junctions with magnetophoretic circuitry elements could lead to novel platforms without retrieving for the synchronous digital manipulation of particles/biomolecules in microfluidic multiplex arrays for next-generation biochips.

Authors:
 [1];  [1];  [1];  [2]; ORCiD logo [2];  [3];  [1];  [1];  [1];  [1];  [4];  [1]
  1. Daegu Gyeongbuk Inst. of Science and Technology (DGIST), Daegu (Korea, Republic of). Dept. of Emerging Materials Science
  2. Argonne National Lab. (ANL), Argonne, IL (United States). Materials Science Division
  3. Daegu Gyeongbuk Inst. of Science and Technology (DGIST), Daegu (Korea, Republic of). Dept. of Emerging Materials Science; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Center for X-ray Optics
  4. Daegu Gyeongbuk Inst. of Science and Technology (DGIST), Daegu (Korea, Republic of). Nano-Bio-materials Division
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22). Scientific User Facilities Division; Samsung, Seoul (Korea, Republic of); Ministry of Science, ICT and Future Planning (MSIP) of Korea
OSTI Identifier:
1461279
Alternate Identifier(s):
OSTI ID: 1436526
Grant/Contract Number:  
AC02-06CH11357; SRFC‐MA1402‐01; 17‐BT‐02; AC02‐05CH11231
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Small
Additional Journal Information:
Journal Volume: 14; Journal Issue: 25; Journal ID: ISSN 1613-6810
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 36 MATERIALS SCIENCE; biofunctionalization; cells sorting; lab-on-a-chip; microparticles manipulation; microrobots

Citation Formats

Hu, Xinghao, Lim, Byeonghwa, Torati, Sri Ramulu, Ding, Junjia, Novosad, Valentine, Im, Mi-Young, Reddy, Venu, Kim, Kunwoo, Jung, Eunjoo, Shawl, Asif Iqbal, Kim, Eunjoo, and Kim, CheolGi. Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery. United States: N. p., 2018. Web. doi:10.1002/smll.201800504.
Hu, Xinghao, Lim, Byeonghwa, Torati, Sri Ramulu, Ding, Junjia, Novosad, Valentine, Im, Mi-Young, Reddy, Venu, Kim, Kunwoo, Jung, Eunjoo, Shawl, Asif Iqbal, Kim, Eunjoo, & Kim, CheolGi. Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery. United States. doi:10.1002/smll.201800504.
Hu, Xinghao, Lim, Byeonghwa, Torati, Sri Ramulu, Ding, Junjia, Novosad, Valentine, Im, Mi-Young, Reddy, Venu, Kim, Kunwoo, Jung, Eunjoo, Shawl, Asif Iqbal, Kim, Eunjoo, and Kim, CheolGi. Tue . "Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery". United States. doi:10.1002/smll.201800504.
@article{osti_1461279,
title = {Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery},
author = {Hu, Xinghao and Lim, Byeonghwa and Torati, Sri Ramulu and Ding, Junjia and Novosad, Valentine and Im, Mi-Young and Reddy, Venu and Kim, Kunwoo and Jung, Eunjoo and Shawl, Asif Iqbal and Kim, Eunjoo and Kim, CheolGi},
abstractNote = {The precise delivery of biofunctionalized matters is of great interest from the fundamental and applied viewpoints. In spite of significant progress achieved during the last decade, a parallel and automated isolation and manipulation of rare analyte, and their simultaneous on-chip separation and trapping, still remain challenging. In this work, a universal micromagnet junction for self-navigating gates of microrobotic particles to deliver the biomolecules to specific sites using a remote magnetic field is described. In the proposed concept, the nonmagnetic gap between the lithographically defined donor and acceptor micromagnets creates a crucial energy barrier to restrict particle gating. It is shown that by carefully designing the geometry of the junctions, it becomes possible to deliver multiple protein-functionalized carriers in high resolution, as well as MCF-7 and THP-1 cells from the mixture, with high fidelity and trap them in individual apartments. Integration of such junctions with magnetophoretic circuitry elements could lead to novel platforms without retrieving for the synchronous digital manipulation of particles/biomolecules in microfluidic multiplex arrays for next-generation biochips.},
doi = {10.1002/smll.201800504},
journal = {Small},
number = 25,
volume = 14,
place = {United States},
year = {Tue May 08 00:00:00 EDT 2018},
month = {Tue May 08 00:00:00 EDT 2018}
}

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Works referenced in this record:

Real-Time DNA Sequencing from Single Polymerase Molecules
journal, January 2009


Chemical Amplification: Continuous-Flow PCR on a Chip
journal, May 1998