Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery
- Daegu Gyeongbuk Inst. of Science and Technology (DGIST), Daegu (Korea, Republic of). Dept. of Emerging Materials Science
- Argonne National Lab. (ANL), Argonne, IL (United States). Materials Science Division
- Daegu Gyeongbuk Inst. of Science and Technology (DGIST), Daegu (Korea, Republic of). Dept. of Emerging Materials Science; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Center for X-ray Optics
- Daegu Gyeongbuk Inst. of Science and Technology (DGIST), Daegu (Korea, Republic of). Nano-Bio-materials Division
The precise delivery of biofunctionalized matters is of great interest from the fundamental and applied viewpoints. In spite of significant progress achieved during the last decade, a parallel and automated isolation and manipulation of rare analyte, and their simultaneous on-chip separation and trapping, still remain challenging. Here, a universal micromagnet junction for self-navigating gates of microrobotic particles to deliver the biomolecules to specific sites using a remote magnetic field is described. In the proposed concept, the nonmagnetic gap between the lithographically defined donor and acceptor micromagnets creates a crucial energy barrier to restrict particle gating. It is shown that by carefully designing the geometry of the junctions, it becomes possible to deliver multiple protein-functionalized carriers in high resolution, as well as MCF-7 and THP-1 cells from the mixture, with high fidelity and trap them in individual apartments. Integration of such junctions with magnetophoretic circuitry elements could lead to novel platforms without retrieving for the synchronous digital manipulation of particles/biomolecules in microfluidic multiplex arrays for next-generation biochips.
- Research Organization:
- Argonne National Laboratory (ANL), Argonne, IL (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division; Samsung, Seoul (Korea, Republic of); Ministry of Science, ICT and Future Planning (MSIP) of Korea
- Grant/Contract Number:
- AC02-06CH11357; SRFC‐MA1402‐01; 17‐BT‐02; AC02‐05CH11231; AC02-05CH11231
- OSTI ID:
- 1461279
- Alternate ID(s):
- OSTI ID: 1436526; OSTI ID: 1530365
- Journal Information:
- Small, Vol. 14, Issue 25; ISSN 1613-6810
- Publisher:
- WileyCopyright Statement
- Country of Publication:
- United States
- Language:
- English
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