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Title: Crystal structures of amyloidogenic segments of human transthyretin: Amyloid Structures of Transthyretin Segments

Authors:
ORCiD logo [1];  [1];  [1];  [1]
  1. Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, Box 951570, UCLA, Howard Hughes Medical Institute, UCLA-DOE Institute, Los Angeles California 90095-1570
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
UNIVERSITY
OSTI Identifier:
1459976
Resource Type:
Journal Article
Journal Name:
Protein Science
Additional Journal Information:
Journal Volume: 27; Journal Issue: 7; Journal ID: ISSN 0961-8368
Publisher:
The Protein Society
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Saelices, Lorena, Sievers, Stuart A., Sawaya, Michael R., and Eisenberg, David S. Crystal structures of amyloidogenic segments of human transthyretin: Amyloid Structures of Transthyretin Segments. United States: N. p., 2018. Web. doi:10.1002/pro.3420.
Saelices, Lorena, Sievers, Stuart A., Sawaya, Michael R., & Eisenberg, David S. Crystal structures of amyloidogenic segments of human transthyretin: Amyloid Structures of Transthyretin Segments. United States. doi:10.1002/pro.3420.
Saelices, Lorena, Sievers, Stuart A., Sawaya, Michael R., and Eisenberg, David S. Wed . "Crystal structures of amyloidogenic segments of human transthyretin: Amyloid Structures of Transthyretin Segments". United States. doi:10.1002/pro.3420.
@article{osti_1459976,
title = {Crystal structures of amyloidogenic segments of human transthyretin: Amyloid Structures of Transthyretin Segments},
author = {Saelices, Lorena and Sievers, Stuart A. and Sawaya, Michael R. and Eisenberg, David S.},
abstractNote = {},
doi = {10.1002/pro.3420},
journal = {Protein Science},
issn = {0961-8368},
number = 7,
volume = 27,
place = {United States},
year = {2018},
month = {6}
}

Works referenced in this record:

Out-of-register  -sheets suggest a pathway to toxic amyloid aggregates
journal, December 2012

  • Liu, C.; Zhao, M.; Jiang, L.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 51
  • DOI: 10.1073/pnas.1218792109

Shape Complementarity at Protein/Protein Interfaces
journal, December 1993

  • Lawrence, Michael C.; Colman, Peter M.
  • Journal of Molecular Biology, Vol. 234, Issue 4
  • DOI: 10.1006/jmbi.1993.1648

The Amyloid State of Proteins in Human Diseases
journal, March 2012


Structural Studies of Amyloid Proteins at the Molecular Level
journal, June 2017


Refinement of Macromolecular Structures by the Maximum-Likelihood Method
journal, May 1997

  • Murshudov, G. N.; Vagin, A. A.; Dodson, E. J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 53, Issue 3
  • DOI: 10.1107/S0907444996012255

Amyloid deposits in transthyretin-derived amyloidosis: cleaved transthyretin is associated with distinct amyloid morphology
journal, January 2005

  • Bergström, Joakim; Gustavsson, Åsa; Hellman, Ulf
  • The Journal of Pathology, Vol. 206, Issue 2
  • DOI: 10.1002/path.1759

Molecular basis for amyloid-  polymorphism
journal, September 2011

  • Colletier, J. -P.; Laganowsky, A.; Landau, M.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 41
  • DOI: 10.1073/pnas.1112600108

Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS)
journal, July 2017

  • Sangwan, Smriti; Zhao, Anni; Adams, Katrina L.
  • Proceedings of the National Academy of Sciences, Vol. 114, Issue 33
  • DOI: 10.1073/pnas.1705091114

Transthyretin (Prealbumin) in Health and Disease: Nutritional Implications
journal, July 1994


Uncovering the Mechanism of Aggregation of Human Transthyretin
journal, October 2015

  • Saelices, Lorena; Johnson, Lisa M.; Liang, Wilson Y.
  • Journal of Biological Chemistry, Vol. 290, Issue 48
  • DOI: 10.1074/jbc.M115.659912

Identifying the amylome, proteins capable of forming amyloid-like fibrils
journal, February 2010

  • Goldschmidt, Lukasz; Teng, Poh K.; Riek, Roland
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 8
  • DOI: 10.1073/pnas.0915166107

Solvent-accessible surfaces of proteins and nucleic acids
journal, August 1983


Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis
journal, December 2015

  • Gertz, Morie A.; Benson, Merrill D.; Dyck, Peter J.
  • Journal of the American College of Cardiology, Vol. 66, Issue 21
  • DOI: 10.1016/j.jacc.2015.09.075

Atomic structure and hierarchical assembly of a cross-  amyloid fibril
journal, March 2013

  • Fitzpatrick, A. W. P.; Debelouchina, G. T.; Bayro, M. J.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 14
  • DOI: 10.1073/pnas.1219476110

Atomic structures of amyloid cross-β spines reveal varied steric zippers
journal, April 2007

  • Sawaya, Michael R.; Sambashivan, Shilpa; Nelson, Rebecca
  • Nature, Vol. 447, Issue 7143
  • DOI: 10.1038/nature05695

Relaxation of backbone bond geometry improves protein energy landscape modeling: Relaxation of Backbone Bond Geometry
journal, November 2013

  • Conway, Patrick; Tyka, Michael D.; DiMaio, Frank
  • Protein Science, Vol. 23, Issue 1
  • DOI: 10.1002/pro.2389

Structure of prealbumin: Secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 Å
journal, May 1978


Structure-based inhibitors of tau aggregation
journal, November 2017

  • Seidler, P. M.; Boyer, D. R.; Rodriguez, J. A.
  • Nature Chemistry, Vol. 10, Issue 2
  • DOI: 10.1038/nchem.2889

Atomic View of a Toxic Amyloid Small Oligomer
journal, March 2012


The interpretation of protein structures: Estimation of static accessibility
journal, February 1971


Common core structure of amyloid fibrils by synchrotron X-ray diffraction 1 1Edited by F. E. Cohen
journal, October 1997

  • Sunde, Margaret; Serpell, Louise C.; Bartlam, Mark
  • Journal of Molecular Biology, Vol. 273, Issue 3
  • DOI: 10.1006/jmbi.1997.1348

Molecular mechanisms for protein-encoded inheritance
journal, August 2009

  • Wiltzius, Jed J. W.; Landau, Meytal; Nelson, Rebecca
  • Nature Structural & Molecular Biology, Vol. 16, Issue 9
  • DOI: 10.1038/nsmb.1643

Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets
journal, January 2016

  • Soriaga, Angela B.; Sangwan, Smriti; Macdonald, Ramsay
  • The Journal of Physical Chemistry B, Vol. 120, Issue 26
  • DOI: 10.1021/acs.jpcb.5b09981

The 3D profile method for identifying fibril-forming segments of proteins
journal, March 2006

  • Thompson, M. J.; Sievers, S. A.; Karanicolas, J.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 11
  • DOI: 10.1073/pnas.0511295103

Structure of the cross-β spine of amyloid-like fibrils
journal, June 2005

  • Nelson, Rebecca; Sawaya, Michael R.; Balbirnie, Melinda
  • Nature, Vol. 435, Issue 7043
  • DOI: 10.1038/nature03680

Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206

A new amyloidogenic transthyretin variant, [D38A], detected by electrospray ionization / mass spectrometry
journal, January 1999


Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients
journal, September 2017