Methods for diagnosing bacterial infections

Timmins, Graham; Silks, Louis Pete

Methods for diagnosing bacterial infections

Patent · 19 June 2018

OSTI ID:1459532

Timmins, Graham; Silks, Louis Pete

The present invention is directed to methods of determining the presence or absence of a bacterial infection in a patient using isotopically-labeled tyrosine and/or isotopically-labeled p-hydroxyphenylacetic acid.

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-06NA25396

Assignee:: STC.UNM (Albuquerque, NM); LOS ALAMOS NATIONAL SECURITY, LLC. (Los Alamos, NM)

Patent Number(s):: 10,000,787

Application Number:: 14/434,509

OSTI ID:: 1459532

Country of Publication:: United States

Language:: English

References (12)

Water works: an efficient palladium-catalyzed cross-coupling reaction between boronic acids and bromoacetate with aminophosphine ligand Peng, Zhi-Yong; Wang, Jian-Ping; Cheng, Jiang Tetrahedron, Vol. 66, Issue 42, p. 8238-8241 https://doi.org/10.1016/j.tet.2010.08.047	journal	October 2010
Tests for the diagnosis of Clostridium difficile infection: The next generation Carroll, Karen C. Anaerobe, Vol. 17, Issue 4, p. 170-174 https://doi.org/10.1016/j.anaerobe.2011.01.002	journal	August 2011
An Epidemic, Toxin Gene–Variant Strain of Clostridium difficile McDonald, L. Clifford; Killgore, George E.; Thompson, Angela New England Journal of Medicine, Vol. 353, Issue 23, p. 2433-2441 https://doi.org/10.1056/nejmoa051590	journal	December 2005
Toxicity of Free p-Cresol: A Prospective and Cross-Sectional Analysis De Smet, Rita; Van Kaer, Jacqueline; Van Vlem, Bruno Clinical Chemistry, Vol. 49, Issue 3, p. 470-478 https://doi.org/10.1373/49.3.470	journal	March 2003
The in vivo use of the stable isotope-labelled biomarkers lactose-[¹⁵N]ureide and [²H₄]tyrosine to assess the effects of pro- and prebiotics on the intestinal flora of healthy human volunteers De Preter, V.; Geboes, K.; Verbrugghe, K. British Journal of Nutrition, Vol. 92, Issue 3, p. 439-446 https://doi.org/10.1079/BJN20041228	journal	September 2004
Increase in Adult Clostridium difficile –related Hospitalizations and Case-Fatality Rate, United States, 2000–2005 Zilberberg, Marya D.; Shorr, Andrew F.; Kollef, Marin H. Emerging Infectious Diseases, Vol. 14, Issue 6, p. 929-931 https://doi.org/10.3201/eid1406.071447	journal	June 2008
The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains Dawson, Lisa F.; Donahue, Elizabeth H.; Cartman, Stephen T. BMC Microbiology, Vol. 11, Issue 1, Article No. 86 https://doi.org/10.1186/1471-2180-11-86	journal	January 2011
¹³[C]-Urea Breath Test as a Novel Point-of-Care Biomarker for Tuberculosis Treatment and Diagnosis Jassal, Mandeep S.; Nedeltchev, Gueno G.; Lee, Jong-Hee PLoS ONE, Vol. 5, Issue 8, Article No. e12451 https://doi.org/10.1371/journal.pone.0012451	journal	August 2010
Assessing the role of p-cresol tolerance in Clostridium difficile Dawson, L. F.; Stabler, R. A.; Wren, B. W. Journal of Medical Microbiology, Vol. 57, Issue 6, p. 745-749 https://doi.org/10.1099/jmm.0.47744-0	journal	June 2008
The origin of urinary tyramine. Formation in tissues and by intestinal microorganisms Asatoor, A. M. Clinica Chimica Acta, Vol. 22, Issue 2 https://doi.org/10.1016/0009-8981(68)90362-8	journal	October 1968
Prospective study of Clostridium difficile colonization and para-cresol detection in the stools of babies on a special care unit Phua, T. J.; Rogers, T. R.; Pallett, A. P. Journal of Hygiene, Vol. 93, Issue 1, p. 17-25 https://doi.org/10.1017/S0022172400060885	journal	August 1984
The economic burden of Clostridium difficile McGlone, S. M.; Bailey, R. R.; Zimmer, S. M. Clinical Microbiology and Infection, Vol. 18, Issue 3, p. 282-289 https://doi.org/10.1111/j.1469-0691.2011.03571.x	journal	March 2012

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Methods for diagnosing bacterial infections

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