skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Nonlinear dynamics of dipoles in microtubules: Pseudospin model

Abstract

We perform a theoretical study of the dynamics of the electric field excitations in a microtubule by taking into consideration the realistic cylindrical geometry, dipole-dipole interactions of the tubulin-based protein heterodimers, the radial electric field produced by the solvent, and a possible degeneracy of energy states of individual heterodimers. The consideration is done in the frame of the classical pseudospin model. We derive the system of nonlinear dynamical partial differential equations of motion for interacting dipoles and the continuum version of these equations. We obtain the solutions of these equations in the form of snoidal waves, solitons, kinks, and localized spikes. Our results will help to achieve a better understanding of the functional properties of microtubules including the motor protein dynamics and the information transfer processes. Our considerations are based on classical dynamics. Finally, some speculations on the role of possible quantum effects are also made.

Authors:
 [1];  [1];  [2];  [3]
  1. Univ. de Guadalajara, Jalisco (Mexico). Centro Univ. de Ciencias Exactas e Ingenierias, Dept. de Fisica
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  3. King's College London, London (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1458943
Alternate Identifier(s):
OSTI ID: 1258706
Report Number(s):
LA-UR-16-22690
Journal ID: ISSN 2470-0045; PLEEE8
Grant/Contract Number:  
AC52-06NA25396
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Physical Review E
Additional Journal Information:
Journal Volume: 93; Journal Issue: 6; Journal ID: ISSN 2470-0045
Publisher:
American Physical Society (APS)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; Biological Science

Citation Formats

Nesterov, Alexander I., Ramirez, Monica F., Berman, Gennady P., and Mavromatos, Nick E. Nonlinear dynamics of dipoles in microtubules: Pseudospin model. United States: N. p., 2016. Web. doi:10.1103/PhysRevE.93.062412.
Nesterov, Alexander I., Ramirez, Monica F., Berman, Gennady P., & Mavromatos, Nick E. Nonlinear dynamics of dipoles in microtubules: Pseudospin model. United States. doi:10.1103/PhysRevE.93.062412.
Nesterov, Alexander I., Ramirez, Monica F., Berman, Gennady P., and Mavromatos, Nick E. Tue . "Nonlinear dynamics of dipoles in microtubules: Pseudospin model". United States. doi:10.1103/PhysRevE.93.062412. https://www.osti.gov/servlets/purl/1458943.
@article{osti_1458943,
title = {Nonlinear dynamics of dipoles in microtubules: Pseudospin model},
author = {Nesterov, Alexander I. and Ramirez, Monica F. and Berman, Gennady P. and Mavromatos, Nick E.},
abstractNote = {We perform a theoretical study of the dynamics of the electric field excitations in a microtubule by taking into consideration the realistic cylindrical geometry, dipole-dipole interactions of the tubulin-based protein heterodimers, the radial electric field produced by the solvent, and a possible degeneracy of energy states of individual heterodimers. The consideration is done in the frame of the classical pseudospin model. We derive the system of nonlinear dynamical partial differential equations of motion for interacting dipoles and the continuum version of these equations. We obtain the solutions of these equations in the form of snoidal waves, solitons, kinks, and localized spikes. Our results will help to achieve a better understanding of the functional properties of microtubules including the motor protein dynamics and the information transfer processes. Our considerations are based on classical dynamics. Finally, some speculations on the role of possible quantum effects are also made.},
doi = {10.1103/PhysRevE.93.062412},
journal = {Physical Review E},
number = 6,
volume = 93,
place = {United States},
year = {Tue Jun 21 00:00:00 EDT 2016},
month = {Tue Jun 21 00:00:00 EDT 2016}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Citation Metrics:
Cited by: 1 work
Citation information provided by
Web of Science

Save / Share: